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Vaccine-induced immune response to omicron wanes substantially over time
https://medicalxpress.com ^ | JULY 19, 2022 | by NIH/National Institute of Allergy and Infectious Diseases

Posted on 07/19/2022 1:04:48 PM PDT by Red Badger

Graphical abstract. Credit: Cell Reports Medicine (2022).

DOI: 10.1016/j.xcrm.2022.100679

Although COVID-19 booster vaccinations in adults elicit high levels of neutralizing antibodies against the omicron variant of SARS-CoV-2, antibody levels decrease substantially within 3 months, according to new clinical trial data. The findings, published today in Cell Reports Medicine, are from a study sponsored by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health. The trial was led by NIAID's Infectious Diseases Clinical Research Consortium.

As part of a "mix and match" clinical trial, investigators administered COVID-19 booster vaccines to adults in the United States who had previously received a primary COVID-19 vaccination series under Emergency Use Authorization. Some participants received the same vaccine as their primary series, and others received a different vaccine. Investigators then evaluated immune responses over time. Results previously reported in The New England Journal of Medicine showed all combinations of primary and booster vaccines resulted in increased neutralizing antibody levels in the recipients.

In the new analysis, investigators report that nearly all vaccine combinations evaluated elicited high levels of neutralizing antibodies to the omicron BA.1 sub-lineage. However, antibody levels against omicron were low in the group that received Ad26.COV2.S as both a primary vaccine and boost. Moreover, immune responses to omicron in all groups waned substantially, with neutralizing antibody levels decreasing 2.4- to 5.3-fold by three months post-boost.

The table above shows the COVID-19 vaccine combinations from the “mix & match” study evaluated in this report. Credit: NIAID

Omicron sub-lineages BA.2.12.1 and BA.4/BA.5 were 1.5 and 2.5 times less susceptible to neutralization, respectively, compared to the BA.1 sub-lineage, and 7.5 and 12.4 times less susceptible relative to the ancestral D614G strain. BA.5 currently is the dominant variant in the U.S.

The authors note that the findings are consistent with real-world reports showing waning protection against SARS-CoV-2 infection during the omicron wave in people who received a primary vaccine series plus a booster shot. Additionally, the immune response to omicron sub-lineages show reduced susceptibility to these rapidly emerging subvariants. The data could be used to inform decisions regarding future vaccine schedule recommendations, including the need for variant vaccine boosting.

Explore further

Pfizer booster more than 50% protective against omicron More information: Kirsten E. Lyke et al, Rapid decline in vaccine-boosted neutralizing antibodies against SARS-CoV-2 Omicron variant, Cell Reports Medicine (2022). DOI: 10.1016/j.xcrm.2022.100679 Journal information: New England Journal of Medicine , Cell Reports Medicine Provided by NIH/National Institute of Allergy and Infectious Diseases


TOPICS: Business/Economy; Education; Health/Medicine; Science
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1 posted on 07/19/2022 1:04:48 PM PDT by Red Badger
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To: Red Badger

🔬🦠😵‍💫😷💉🚫🐎💩


2 posted on 07/19/2022 1:06:02 PM PDT by rktman (Destroy America from within? Check! WTH? Enlisted USN 1967 to end up with this? 😕)
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To: Red Badger

....within 3 months...

But yeah, keep making yourselves feel better thinking its an actual vaccine.................


3 posted on 07/19/2022 1:06:10 PM PDT by cranked
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To: Red Badger

Big Pharma conference meeting:
“So if they all need a new booster shot every month we could stand to make an unprecedented explosion of high profits selling them.”

Boss: “I don’t know about the patients but I’m feeling better by the minute.”


4 posted on 07/19/2022 1:15:36 PM PDT by frank ballenger (You have summoned up a thundercloud. You're gonna hear from me. Anthem by Leonard Cohen)
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To: Red Badger

What a surprise when they are using a useless vax.

The vax is for the original strain.

You might as well depend on using the year before lasts flu shot for next years strain of the flu.


5 posted on 07/19/2022 1:16:21 PM PDT by metmom (...fixing our eyes on Jesus, the Author and Perfecter of our faith…)
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To: Red Badger

biden proved the kung flu is a scam when he waltzed into the white house, disbanded trump’s “operation warp speed”, opened our southern border, and continues to spread over 2,000,000 (2 million) nondocumented unvaccinated invaders across our country during a supposed “global pandemic” while anthony fauci, the cdc, the nih, the world health organization, the enemedia, hollywierd, and the majority of our elected representatives sit back and watch...

trust the biden administration to protect you and your health at your own peril...


6 posted on 07/19/2022 1:23:46 PM PDT by heavy metal (smiling improves your face value and makes people wonder what the hell you're up to... 😁)
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To: Red Badger

But the ill effects to your immune system don’t dissipate.


7 posted on 07/19/2022 1:38:08 PM PDT by Track9 (You are far too inquisitive not to be seduced…)
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To: cranked

A vaccine is one shot. Maybe with a booster many years later. This mess is an experiment.


8 posted on 07/19/2022 2:26:32 PM PDT by ealgeone
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To: ealgeone
A vaccine is one shot. Maybe with a booster many years later. This mess is an experiment.

The life expectancy of Americans has decreased almost two years thanks to the dangerous, sometimes fatal vaxxxxxxines.

As the vaxxxxxines are all starting autoimmune attacks on the vaxxxxxxed, expect the death numbers to increase substantially as the vaxxxxxxines kill more and more of the vaxxxxed. And there is no treatment to stop these vaxxxxxxine caused autoimmune attacks..

9 posted on 07/19/2022 2:54:21 PM PDT by politicianslie (Those who got vaxxed need to update their wills. You are a guinea pig in a dangerous drug trial.)
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To: cranked

Keep on, keep on, keep on boooooo$tin’! 🕺🏻 🎶


10 posted on 07/19/2022 2:56:30 PM PDT by Jane Long (What we were told was a “conspiracy theorybe” in 2020 is now fact. 🙏🏻 Ps 33:12)
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To: Track9

Exactly. If only they did. :-(


11 posted on 07/19/2022 2:57:07 PM PDT by Jane Long (What we were told was a “conspiracy theorybe” in 2020 is now fact. 🙏🏻 Ps 33:12)
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To: politicianslie

And life insurance rates are going up because....of......
“unexpected” and “suddenly” and “found unresponsive” results of experiments.


12 posted on 07/19/2022 3:07:46 PM PDT by JCL3 (As Richard Feynman might have said, this is reality taking precedence over public relations.)
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To: Red Badger

That’s obvious. Otherwise how would you get someone to pay for the next?

Repeat customers make a going concern!


13 posted on 07/19/2022 3:16:44 PM PDT by glorgau
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To: Jane Long

Pretty convenient for pzier for making new drugs when they’re the ones creating the conditions.


14 posted on 07/19/2022 3:43:41 PM PDT by Track9 (You are far too inquisitive not to be seduced…)
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To: Jane Long

Meanwhile, DugwayDuke and the rest of the Branch Covidians are nowhere to be found.


15 posted on 07/19/2022 7:13:07 PM PDT by wjcsux (RIP Rush Limbaugh 12 Jan 1951- 17 Feb 2021. We really miss you. 😢)
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To: JCL3

Life ins companies are now trying to quickly buy out policies.


16 posted on 07/19/2022 7:17:02 PM PDT by Jane Long (What we were told was a “conspiracy theorybe” in 2020 is now fact. 🙏🏻 Ps 33:12)
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To: wjcsux

The paychecks must’ve hit a snag.


17 posted on 07/19/2022 7:17:31 PM PDT by Jane Long (What we were told was a “conspiracy theorybe” in 2020 is now fact. 🙏🏻 Ps 33:12)
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To: Jane Long

“The paychecks must’ve hit a snag.”
Yep, they are probably shills for Big Pharma or government hacks.


18 posted on 07/19/2022 8:23:08 PM PDT by wjcsux (RIP Rush Limbaugh 12 Jan 1951- 17 Feb 2021. We really miss you. 😢)
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To: wjcsux

Same diff.


19 posted on 07/19/2022 8:46:20 PM PDT by Jane Long (What we were told was a “conspiracy theorybe” in 2020 is now fact. 🙏🏻 Ps 33:12)
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To: glorgau

Killing your customers is not a good business model...................


20 posted on 07/20/2022 5:35:24 AM PDT by Red Badger (Homeless veterans camp in the streets while illegal aliens are put up in hotels.....................)
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