Posted on 07/04/2022 1:29:59 PM PDT by ConservativeMind
A study reveals new insights into how gastric cancer develops and suggests a preventive treatment.
Eunyoung Choi, Ph.D. identified for the first time that Trop2+/CD133+/CD166+ dysplastic stem cells are a key source of clonal evolution of dysplasia to multiple types of gastric cancer. Their investigation further showed that pyrvinium, a commonly prescribed treatment for intestinal pinworms, blocked regeneration of dysplastic stem cells by controlling the CK1a signaling protein in mouse models and in human organoids.
"The dysplastic stem cells that we identified are de novo stem cells first present during carcinogenic transition of pre-cancerous metaplasia to dysplasia in both mouse and human stomachs. Our study also demonstrated cell fate dynamics and evolutionary process of dysplastic stem cells as a single-type of non-cancerous stem cells in dysplasia and provided a clue, which explains full spectrum of a carcinogenic cascade, normal-metaplasia-dysplasia-adenocarcinoma, during gastric cancer development," said Choi.
Globally, gastric cancer is the fifth most common cancer and the third deadliest. Dysplasia, the abnormal growth or development of cells, carries a high risk for progression to gastric cancer.
In this latest study, they conducted transcriptome analysis utilizing dysplastic organoids from active KRAS gene-induced mouse stomachs.
"Stemness and plasticity of dysplastic stem cells led to the sequential progression of gastric adenocarcinomas and recapitulated tumor heterogeneity and genetic alterations observed in human gastric cancers," said Jimin Min, Ph.D.
Pyrvinium is a CK1a agonist that has anti-cancer effects. The researchers found that it could selectively block stemness and viability of both mouse and human dysplastic stem cells. The current standard of treatment for gastric dysplasia is endoscopic resection or surgical excision of small lesions. The researchers concluded that controlling dysplastic stem cell activity with a CK1a agonist targeted therapeutic intervention may be an effective approach to reduce the risk of dysplasia progression to gastric cancer.
(Excerpt) Read more at medicalxpress.com ...
Need a prescription?
Bkmrk
Hmmm, how abut Ivermectin? Another anti-parasitic. Nah, it’s a horse drug...
And fenbendazole.
Castor oil with turpentine.
There are encouraging studies, already, on ivermectin as an anti-cancer drug.
What are the side effects? Would it be a good idea for someone without symptoms? How does a physician know when to prescribe?
Lot of older ppl aware of links between parasites and cancer.
Extensively researched, along with therapies and antiparasitical items in “The Cure For All Diseases”, in the mentioned and 5 other books by researcher Hulda Clark.
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