Posted on 06/12/2022 8:03:36 PM PDT by ConservativeMind
Polyphenols in foods we eat can prevent inflammation in older people, since they alter the intestinal microbiota and induce the production of the indole 3-propionic acid (IPA).
Polyphenols are natural compounds, considered probiotics, which we eat mainly through fruits and vegetables.
The study shows the interaction between polyphenols and gut microbiota can induce the proliferation of bacteria with the ability to synthetize beneficial metabolites, such as IPA, a postbiotic with antioxidant, anti-inflammatory and neuroprotective properties that contributes to improve the health of the intestinal wall. Therefore, this compound would contribute to the prevention of some diseases associated with aging.
Researchers carried out a multiomic analysis to monitor the IPA levels in the serum of fifty-one volunteers who kept following a diet rich in polyphenols (green tea, bitter chocolate, fruits including apples, pomegranate and blueberries) for eight weeks.
The results show that the diet rich in polyphenols generated a significant increase in the blood IPA levels, together with a decrease in inflammation levels and changes in the bacteria of the microbiota.
Surprisingly, the researchers did not observe the same effects in the volunteers with kidney diseases. These people showed lower amounts of IPA at the beginning of the trial compared to the volunteers with normal kidney function.
"These results could be clinically relevant, since the low IPA levels have been associated with a rapid decline of kidney function and a chronic kidney disease," notes Professor Andrés-Lacueva.
Therefore, a polyphenol-rich diet including probiotic foods such as green tea, dark chocolate and some fruits like apples, pomegranate and blueberries could increase the production of IPA through changes in the composition of gut microbiota. This increase in the levels of a postbiotic, such as IPA in the elderly, could be beneficial in delaying or preventing chronic diseases that harm the quality of life.
(Excerpt) Read more at medicalxpress.com ...
For the rest of us, it seems indole 3-propionic acid (IPA) is vital to minimizing kidney disease and other chronic diseases.
Well, I’m outta luck. I’m poor and I can’t afford to move to Polyphenol.
“Therefore, a polyphenol-rich diet including probiotic foods such as ... dark chocolate”
Count me in!
Turmeric (Curcumin) all the way. Decreases inflammation. Cheap. Not even a smidgen of a cut for either the big guy nor Pfizer.
Bookmark
I just bought some stinging nettle.
It seems to have a lot of good molecules in it.
there are no medical research studies that validate this...no
studies by pharmaceutical or mainstream studies..moreover no other studies of any kind—even not “ natural or hoistic studies”
I have a six-pack of IPA in my fridge.
Bailing a leaky boat.
bkmk
Ping
It is in coffee.
Turmeric has pretty much cleared up my psoriasis. No more scales/plaques.
Thanks
An apple a day.
Push the vegetables.
Did you apply tumeric to the skin?
Quercetin
Years back I ask my Doctor about the gut-brain connection and he said it is real and there is much to learn about it.
A long and very enjoyable discussion about some of the many gut connections.
WARNING! If you start you may not want to stop watching.
I planned two sessions but could not stop and was up past my bedtime.
Dr Huberman is a professor of neurobiology at Stanford.
He has many great podcasts and very few short ones.
Very easy to follow, most is explained in easy English.
https://youtu.be/ouCWNRvPk20
Enjoy.
“My guest this episode is Dr. Justin Sonnenburg, Professor of Microbiology & Immunology at Stanford University. Dr. Sonnenburg’s research focuses on how microbes in our gut impact our mental and physical health and how diet and your environment shape your gut microbiome. We discuss the architecture of the gut microbiome and microbiota variability in different regions of the gastrointestinal (GI) tract and how these can change in response to diet, environment or genetics. We explore the early establishment of your microbiome and how your mode of delivery into the world (C-section or not) shapes your gut. We also discuss lifestyle factors that can alter your microbiome and the integral role the gut microbiome plays in communicating to other organs, including your brain. Dr. Sonnenburg details his recent clinical study, which found that diets rich in fermented foods (but not fiber) increase microbiota diversity and reduce signals of inflammation. Additionally, we examine how foods typical in Western Diets (e.g., high fat, low fiber, processed foods) can negatively impact the gut microbiome. Throughout the episode, we discuss actionable tools from peer-reviewed clinical findings that anyone can implement, regardless of budget, in order to optimize their gut microbiome and health.”
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