...and your point is? 🥸
Doesn’t interest me, but thanks.
I just peeked to see who understands and enjoys this topic.
Sometimes the microcosm resembles the macrocosm. That picture on the upper left looks like a wreath of flowers and vines to me. Interesting.
Does this have anything to do with sex?
“The inner and outer Y complexes are colored dark and light gray, respectively.”
That was a good choice. Gray goes with anything.
It’s research into spinal chord formation. ‘Xenopus’ is an african frog that is used as a handy organism for study.
Xenu won’t be pleased.
Abstract
Nuclear pore complexes (NPCs) are the gateways connecting
the nucleoplasm and cytoplasm. This structures are
composed of over 30 different proteins and 60–125 MDa of
mass depending on type of species. NPCs are bilateral
pathways that selectively control the passage of
macromolecules into and out of the nucleus. Molecules
smaller than 40 kDa diffuse through the NPC passively
while larger molecules require facilitated transport
provided by their attachment to karyopherins. Kinetic
studies have shown that approximately 1000
translocations occur per second per NPC. Maintaining its
high selectivity while allowing for rapid translocation
makes the NPC an efficient chemical nanomachine. In this
review, we approach the NPC function via a structural
viewpoint. Putting together different pieces of this
puzzle, this chapter confers an overall insight into
what molecular processes are engaged in import/export of
active cargos across the NPC and how different
transporters regulate nucleocytoplasmic transport. In
the end, the correlation of several diseases and
disorders with the NPC structural defects and
dysfunctions is discussed. ...
I would guess you are one of the authors of this article but I don’t think you are Chinese.
Bookmark for later after I get my PHD in nuclear physics or something.....
Thanks for posting!
That thing is huge compared to the trans-membrane pore proteins I’ve seen.
You avoided TTIWWOP :)
Read your homepage. liked the ways to spot election fraud link.
Oh yeah? Well, *I’M* of the opinion that the effects of adjuvants for increasing the immunogenicity of influenza vaccines are well known. However, the effect of adjuvants on increasing the breadth of cross-reactivity is less well understood. In this study we have performed a systematic screen of different toll-like receptor (TLR) agonists, with and without a squalene-in-water emulsion on the immunogenicity of a recombinant trimerized hemagglutinin (HA) vaccine in mice after single-dose administration. Antibody (Ab) cross-reactivity for other variants within and outside the immunizing subtype (homosubtypic and heterosubtypic cross-reactivity, respectively) was assessed using a protein microarray approach. Most adjuvants induced broad IgG profiles, although the response to a combination of CpG, MPLA and AddaVax (termed ‘IVAX-1’) appeared more quickly and reached a greater magnitude than the other formulations tested. Antigen-specific plasma cell labeling experiments show the components of IVAX-1 are synergistic. This adjuvant preferentially stimulates CD4 T cells to produce Th1>Th2 type (IgG2c>IgG1) antibodies and cytokine responses. Moreover, IVAX-1 induces identical homo- and heterosubtypic IgG and IgA cross-reactivity profiles when administered intranasally. Consistent with these observations, a single-cell transcriptomics analysis demonstrated significant increases in expression of IgG1, IgG2b and IgG2c genes of B cells in H5/IVAX-1 immunized mice relative to naïve mice, as well as significant increases in expression of the IFNγ gene of both CD4 and CD8 T cells. These data support the use of adjuvants for enhancing the breath and durability of antibody responses of influenza virus vaccines.
So THERE! smarty pants...
Headline of the year!!
Who you callin’ Xenopus, smart guy?!
;-)
Now they’re just making up words...
I want one but only if it comes in Puce and yellow.