Posted on 06/08/2022 9:33:13 AM PDT by SeekAndFind
A study has found that a drug named Dostarlimab has helped treat rectal cancer. This has been described as a "first time in history"kind of result in cancer treatment with the disease simply vanishing in patients after the experimental treatment.
1. The clinical trial comprised a group of 18 patients. All of them were battling rectal cancer at the Memorial Sloan Kettering Cancer Center in Manhattan, US.
2. In all patients, rectal cancer was locally advanced. This means the tumours had spread within the rectum and in some cases, to the lymph nodes, but not to other organs.
3. The drug named Dostarlimab was administered to the patients for a period of six months. The medicine was given in prescribed dosages every three weeks for the said period.
4. At the end of the trial, cancer was checked for and remained undetected through physical exam, endoscopy, positron emission tomography or PET scans or MRI scans.
5. According to New York Times , the medicine costs nearly $11,000 per dose.
6. Dostarlimab works by "unmasking" cancer cells, which in turn helps the immune system identify and destroy them.
7. The rectal cancer study was inspired by a clinical trial conducted by Dr. Luis A. Diaz Jr. of Memorial Sloan Kettering Cancer Center led in 2017.
8. The patients involved in the clinical trial had undergone previous treatments to manage their cancer, including chemotherapy, radiation, and invasive surgery. Post the trial, they were able to be taken off painful chemotherapy and radiation sessions.
9. Patients showed a complete absence of significant post-treatment complications as well as any signs of recurrence of cancer in the patients until 25 months from the end of the trial.
10. The study was sponsored by the drug company GlaxoSmithKline.
Wonderful news, but I always get an “I Am Legend” dread when I read these stories.
IIRC from another article, this is a monoclonal antibody drug, correct?
12 The patients all had a very specific sub-type of cancer that was susceptible to this treatment. The sub-type makes up 5%-10% of all rectal cancers.
True, but the good news the dose only costs 11,000 dollars every three weeks.
Made from fully humanized mice. Gross
Probably therefore linked to abortion
RE: IIRC from another article, this is a monoclonal antibody drug, correct?
See here:
[EXCERPT]
Who Makes Dostarlimab?
Developed by a biotech company out of Massachusetts called Tesaro before being acquired by GlaxoSmithKline in 2019, dostarlimab is also known by the brand name Jemparli.
First approved in the United States for use as a cancer treatment in early 2021, dostarlimab is a monoclonal antibody.
What Are Monoclonal Antibodies?
Monoclonal antibodies like dostarlimab are laboratory-made antibodies design to fight specific illnesses.
The term became more widely known in the last two years as a variety of monoclonal antibodies came out to treat COVID-19.
Dostarlimab is specifically designed to block a particular protein involved in cancer cells called PD-1.
In the Memorial Sloan Kettering trial with rectal cancer, all of the patients’ tumors also had a feature known as mismatch repair deficiency.
What Is Mismatch Repair Deficiency?
Cells that have mutations that keep them from fixing mistakes when DNA is copied are said to have “mismatch repair deficiency.”
Having mismatch repair deficiency can be associated with cells becoming cancerous.
RE: True, but the good news the dose only costs 11,000 dollars every three weeks.
Eventually, If it actually works and is approved, it should be covered by insurance and Medicare/Medicaid.
This is the kind of thing that inspires young people to go intro the sciences and research. I say, my hats off to the researchers! Congratulations, and I hope they continue to find ways to get rid of cancer. For real, instead of just putting a bandaid on it.
Pharmas aren’t to be trusted anymore. Other info on Glaxo Smith Kline’s product imply the ‘leveraging’ of human genetics and immune system - which sounds just like the needless, toxic Covid ‘vaccines’, so I suspect this is related technology but they know to hide the details from us. Just my 2.
Not exactly, the mouse anti-body was humanized independently, cloned and then tested on humanized mice before being approved for human testing. Interestingly, the humanized mouse antibody no longer worked on non humanized mice.
Taking bets on when this drug will be approved and released by the FDA:
1. 20 years
2. 10 years
3. Never
It’s also approved for endometrial cancer in women with the same dna repair defect.
The thing is, if they can create an antibody cure for one specific type of cancer, they can and will create them for other types of cancer.
And the price will come down as the technology spreads and develops and the patents expire.
11k per dose times 8 doses means 88k to essentially cure this variety of cancer. Compared to prolonged alternative treatments, surgeries etc, that the patients had already been through unsuccessfully, that is probably a great bargain.
The last thing they want is a cure for cancer or heart disease. There is too much money to be made from lifelong treatments. Once you’re cured, you don’t need them.
And then add another ten years before it gets standard of care coverage by insurance companies.
I wish they would come up with kidney regeneration. Mine are almost kaput.
Most drug names ending in "mab" are monoclonal antibodies, yes.
There will never be a single cure for cancer because cancer is not a single disease caused by a single pathogen. This treatment works on a single type of cancer that results from mismatch repair–deficiency cellular mutations.
And there will always be people getting one type of cancer or another so there will always be new patients. They don’t even know how long this one will keep the mmrd type cancer at bay. Maybe it’s permanent, maybe it’s good for 5-10 years. Only time will tell.
Nobody is hiding “the cure”. You’re literally complaining about how they don’t want a cure on a thread about a cure for cancer. It’s real and it’s happening and there will be more.
Thanks!
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