Posted on 04/29/2022 2:41:58 PM PDT by ConservativeMind
A molecule produced in the liver in response to low-carb "ketogenic" diets has a powerful effect in suppressing colorectal tumor growth and may be useful as a preventive and treatment of such cancers, according to a new study.
In the study, researchers initially found that mice on low-carb, high-fat ketogenic diets have a striking resistance to colorectal tumor development and growth. The scientists then traced this effect to beta-hydroxybutyrate (BHB), a small organic molecule produced in the liver in response to keto diets or starvation.
In the study, Levy, Thaiss and their teams put six groups of mice on diets that had varying fat-to-carb ratios, and then used a standard chemical technique that normally induces colorectal tumors.
They found that the two most ketogenic diets, with 90 percent fat-to-carb ratios—one used lard (pig fat), the other Crisco (mostly soybean oil)—prevented colorectal tumor development in most of the animals on those diets. By contrast, all the animals on the other diets, including low-fat, high-carb diets, developed tumors. Even when the researchers started the mice on these diets after colorectal tumors had started growing, the diets showed a "treatment effect" by markedly slowing further tumor growth and proliferation.
In subsequent experiments, the scientists determined that this tumor suppression is associated with a slower production, by stem cells, of new epithelial cells lining the colon. Ultimately, they traced this gut-cell growth slowdown to BHB—normally produced by the liver as part of a "starvation response," and triggered in this case by the low-carb keto diets.
…Experiments with gut-lining cells from humans provided evidence that BHB has the same growth-slowing effect on these cells, via human versions of Hcar2 and Hopx. Colorectal tumor cells that don't express these two genes were not responsive to BHB treatment, suggesting their utility as possible predictors of treatment efficiency.
(Excerpt) Read more at medicalxpress.com ...
“A molecule produced in the liver in response to low-carb “ketogenic” diets has a powerful effect in suppressing colorectal tumor growth and may be useful as a preventive and treatment of such cancers, according to a new study.”
Serious stuff and helps explain why the medical community doesn’t want people on Keto.
LOW CARB / KETO PING!!!
Thanks again, CM. More good stuff regarding Keto!
[p.s., anyone wanting to join, or leave, my Low-Carb ping list, just let me know, privately or publicly]
My Keto just loves Gin so I feed it a G n T every evening.
Have you seen the price of meat lately? If we have to start eating demonrats, stock up on marinades to cut the stringiness.
Just started a keto diet last week. Want to see if it will help with inflammation and perhaps lose a few pounds.
Got a sample pack of keto chow.
Not loving it.
Please add me to this list?
Serious stuff and helps explain why the medical community doesn’t want people on Keto.
Keto as a treatment regimen.
Yes.
Keto as a lifestyle will ultimately be shown to be deadly.
Just like the ‘vaccines’.
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