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'Keto' molecule may be useful in preventing and treating colorectal cancer, study suggests (BHB, which only works with cancers having Hcar2 and Hopx receptors)
Medical Xpress / Perelman School of Medicine at the University of Pennsylvania / Nature ^ | Apr. 27, 2022 | Maayan Levy, Ph.D.

Posted on 04/29/2022 2:41:58 PM PDT by ConservativeMind

A molecule produced in the liver in response to low-carb "ketogenic" diets has a powerful effect in suppressing colorectal tumor growth and may be useful as a preventive and treatment of such cancers, according to a new study.

In the study, researchers initially found that mice on low-carb, high-fat ketogenic diets have a striking resistance to colorectal tumor development and growth. The scientists then traced this effect to beta-hydroxybutyrate (BHB), a small organic molecule produced in the liver in response to keto diets or starvation.

In the study, Levy, Thaiss and their teams put six groups of mice on diets that had varying fat-to-carb ratios, and then used a standard chemical technique that normally induces colorectal tumors.

They found that the two most ketogenic diets, with 90 percent fat-to-carb ratios—one used lard (pig fat), the other Crisco (mostly soybean oil)—prevented colorectal tumor development in most of the animals on those diets. By contrast, all the animals on the other diets, including low-fat, high-carb diets, developed tumors. Even when the researchers started the mice on these diets after colorectal tumors had started growing, the diets showed a "treatment effect" by markedly slowing further tumor growth and proliferation.

In subsequent experiments, the scientists determined that this tumor suppression is associated with a slower production, by stem cells, of new epithelial cells lining the colon. Ultimately, they traced this gut-cell growth slowdown to BHB—normally produced by the liver as part of a "starvation response," and triggered in this case by the low-carb keto diets.

…Experiments with gut-lining cells from humans provided evidence that BHB has the same growth-slowing effect on these cells, via human versions of Hcar2 and Hopx. Colorectal tumor cells that don't express these two genes were not responsive to BHB treatment, suggesting their utility as possible predictors of treatment efficiency.

(Excerpt) Read more at medicalxpress.com ...


TOPICS: Health/Medicine
KEYWORDS: bhb; cancer; hcar2; hopx
Beta-hydroxybutyrate (BHB) is freely made in our bodies during fasting or under keto diets and can strongly prevent, or markedly slow, most colon cancers.
1 posted on 04/29/2022 2:41:58 PM PDT by ConservativeMind
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To: Pete from Shawnee Mission; Mazey; ckilmer; goodnesswins; Jane Long; BusterDog; jy8z; ...

The “Take Charge Of Your Health” Ping List

This potentially high volume ping list is for health articles and studies which describe something you or your doctor, when informed, may be able to immediately implement for your benefit.

Now keeping a new list (“Common/Top Issues”) for conditions expected to only concern at least 1% of the population. Ask to be on either the “Common/Top Issues” or “Everything” list.

Please email or private message me if you want on or off of a list and of which list you desire.

2 posted on 04/29/2022 2:42:50 PM PDT by ConservativeMind (Trump: Befuddling Democrats, Republicans, and the Media for the benefit of the US and all mankind.)
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To: ConservativeMind

“A molecule produced in the liver in response to low-carb “ketogenic” diets has a powerful effect in suppressing colorectal tumor growth and may be useful as a preventive and treatment of such cancers, according to a new study.”

Serious stuff and helps explain why the medical community doesn’t want people on Keto.


3 posted on 04/29/2022 2:45:03 PM PDT by BobL (Putin isn't sending gays into our schools to groom my children, but anti-Putin people are)
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To: AlligatorEyes; LouisianaJoanof Arc; dp0622; thesearethetimes...; jacquej; GnuThere; ...

LOW CARB / KETO PING!!!

Thanks again, CM. More good stuff regarding Keto!

[p.s., anyone wanting to join, or leave, my Low-Carb ping list, just let me know, privately or publicly]


4 posted on 04/29/2022 2:48:23 PM PDT by BobL
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To: ConservativeMind

My Keto just loves Gin so I feed it a G n T every evening.


5 posted on 04/29/2022 4:22:03 PM PDT by chopperk
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To: ConservativeMind
Thanks CM. "They found that the two most ketogenic diets, with 90 percent fat-to-carb ratios—one used lard (pig fat), the other Crisco (mostly soybean oil)" Maybe bacon or pork belly occasionally, but I will not use crisco. Keto was originally developed to treat epilepsy, I think by Johns Hopkins. http://www.drpasswater.com/nutrition_library/enig1_interview.html?aid=CD12 Dr Mary Enig was an early researcher regarding the bad effects of hydrogenated fats.
6 posted on 04/29/2022 4:29:43 PM PDT by Pete from Shawnee Mission ( )
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To: BobL

Have you seen the price of meat lately? If we have to start eating demonrats, stock up on marinades to cut the stringiness.


7 posted on 04/29/2022 5:21:29 PM PDT by bgill (Which came first, the vax or the virus?)
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To: ConservativeMind

Just started a keto diet last week. Want to see if it will help with inflammation and perhaps lose a few pounds.

Got a sample pack of keto chow.
Not loving it.


8 posted on 04/29/2022 5:34:40 PM PDT by Chickensoup ( Leftists totalitarian fascists are eradicating conservatives)
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To: ConservativeMind

Please add me to this list?


9 posted on 04/29/2022 5:36:19 PM PDT by Chickensoup ( Leftists totalitarian fascists are eradicating conservatives)
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To: BobL

Serious stuff and helps explain why the medical community doesn’t want people on Keto.


I think this is new information for the medical community. My doc has been urgeing keto for at least 7 years


10 posted on 04/29/2022 5:40:29 PM PDT by Chickensoup ( Leftists totalitarian fascists are eradicating conservatives)
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To: ConservativeMind

Keto as a treatment regimen.

Yes.

Keto as a lifestyle will ultimately be shown to be deadly.

Just like the ‘vaccines’.


11 posted on 04/29/2022 7:25:47 PM PDT by logi_cal869 (-cynicus the "concern troll" a/o 10/03/2018 /!i!! &@$%&*(@ -)
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