Studying intranasal human milk as stem cell therapy in preterm infants with intraventricular hemorrhage

Medical Xpress / American Pediatric Society / Pediatric Academic Societies (PAS) 2022 Meeting ^ | Apr. 22, 2022 | Alessia Gallipoli, MD et al

[ConservativeMind]

A new study demonstrates that intranasal human milk is a safe and feasible intervention for intraventricular hemorrhage, a serious cause of morbidity in preterm infants. Findings from the study will be presented during the Pediatric Academic Societies (PAS) 2022 Meeting, taking place in Denver. This is the first prospective trial on safety and feasibility of intranasal human milk administration in neonates with intraventricular hemorrhage.

Intraventricular hemorrhage is a common cause of brain injury with potential resultant neurodevelopmental sequalae for preterm infants. Stem cell therapies are being developed as a novel brain injury treatment. Fresh human milk contains pluripotent stem cells that produce neuronal cells in vitro. Animal models of neonatal brain injury have found milk stem cells in brain tissue of suckling mice with neuroprotective effects. Nasal vascularity and the permeable neonatal blood brain barrier potentially allow stem cell delivery to brain tissue via fresh intranasal human milk administration.

"Our study, 'Intranasal Human Milk as Stem Cell Therapy in Preterm Infants with Intraventricular Hemorrhage: Safety, Feasibility and Short-Term Outcomes,' attempts to harness the power of fresh human milk, which has stem cells and growth factors, as an intervention for very preterm babies with brain bleeds, a condition currently with no effective therapy," said Alessia Gallipoli, MD, neonatal-perinatal medicine fellow at the University of Toronto. "Our prospective trial in Toronto, the first in the world, showed that these preterm infants were able to tolerate nasal milk therapy through 28 days of life without major safety events. We hope to use this preliminary data to plan a larger trial to gain more information on the effect of intranasal breastmilk on short- and long-term outcomes for this patient population."

[ConservativeMind]

Fascinating use of an already available and free resource to address a health concern in a location milk may only accidentally touch.

[ConservativeMind]

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[gundog]

There was a guy in Basic Training that we subjected to experiments with internasal cow’s milk. We’d get him to laugh with a mouth full of cereal, and he’d go to extreme measures not to draw the TI’s attention by doing so. Good times.

[George from New England]

Like all new meds, there will likely be a warning that says, do not take when pregnant or breastfeeding and use birth control !!

In the end Big Pharma only want meds that have been tested on single individuals, without fetus within. “So you got aids, take this new triple med and abort any unborn — we won’t test that.”