Vitamin E can boost immunotherapy responses by reinvigorating dendritic cells (Breast, colon, kidney, & melanoma cancers benefited - Cannot help w/chemotherapy - multivitamin also helped - “Significantly improved survival”)

Medical Xpress / University of Texas M. D. Anderson Cancer Center / Cancer Discovery ^ | Apr. 14, 2022 | Xiangliang Yuan et al

[ConservativeMind]

Combining a retrospective analysis of clinical records with in-depth laboratory studies, researchers have discovered that vitamin E can enhance immunotherapy responses by stimulating the activity of dendritic cells in the tumor.

The researchers demonstrated that vitamin E directly binds and blocks the activity of the SHP1 checkpoint protein in dendritic cells, which increases antigen presentation and primes T cells for an anti-tumor immune response.

Dietary supplements are thought to boost immunity, but little is known about the effects of supplements on immunotherapy activity.

Patients with melanoma who took vitamin E while on anti-PD-1/PD-L1 checkpoint inhibitors had significantly improved survival compared to patients who didn't take vitamin E or multivitamins. This finding was replicated in an independent mixed cohort of patients with breast, colon and kidney cancers. However, patients taking vitamin E while being treated with chemotherapy did not experience the same benefits, suggesting the effects were unique to chemotherapy.

Next, the researchers demonstrated that vitamin E enhanced responses to checkpoint inhibitors in immunogenic mouse models of breast cancer and melanoma. However, models with low levels of tumor-infiltrating dendritic cells did not benefit from vitamin E, suggesting the effects were dependent on these cells.

The researchers demonstrated that the vitamin E treatment led to upregulation of several activation markers on the dendritic cells. Additionally, dendritic cells from tumors treated with vitamin E promoted more T cell proliferation relative to controls, suggesting vitamin E enhanced the priming step.

Blocking SHP1 genetically mimicked the results with vitamin E, leading to increased antigen presentation that stimulated T cell anti-tumor responses. Similarly, blocking SHP1 enhanced antigen presentation in extracellular vesicles released by dendritic cells—another important mode of communication between dendritic cells and T cells.

[ConservativeMind]

The patient cannot be on chemo for this to work. This approach has to only be with immunotherapy.

I don’t have access to the study, but a prior study showed a special version of Vitamin E, called “Gamma tocotrienol,” worked against cancer by impacting the exact same SHP1 checkpoint protein. Do note normal Vitamin E (alpha tocopherol) supercedes absorption of beta, delta, and gamma tocotrienols and all tocotrienols (alpha, beta, delta, and gamma).

Unfortunately, all four tocopherol and the four tocotrienols are all called “Vitamin E,” so buying access ($50) to this new study would be worthwhile (I didn’t find the type used, elsewhere).

[ConservativeMind]

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[ConservativeMind]

Gamma tocotrienol targets tyrosine phosphatase SHP2 [and SHP1] in mammospheres resulting in cell death through RAS/ERK pathway

https://pubmed.ncbi.nlm.nih.gov/26315028/

[frog in a pot]

Thanks!

This seems helpful info for any who are concerned with improving blood vessel wall function and maintaining healthy cholesterol levels.

Not sure what you wish to convey by the use of "supercedes" followed by "Unfortunately".

Reasonably priced blends of all four tocopherol and the four tocotrienols are readily available on the internet (see, for instance, Vitacost). ???

[Salvation]

Any results of this fighting coronavirus in your research?

[ConservativeMind]

If you take alpha-tocopherol along with the others, you risk having little of the others being absorbed.

[ConservativeMind]

Not that I can recall.

[thinden]

bttt Vit E

[Faith65]

Thanks.
BKMK