Therapeutically effective drugs for bladder cancer identified (Common clofarabine = “Complete remission,” or “Massive, sustained shrinkage” of conventional urothelial or sarcomatoid carcinomas, respectively, “without…apparent side effects”)

Medical Xpress / Medical University of Vienna / European Urology ^ | Apr. 11, 2022 | Johannes Angerer / Iris E. Ertl et al

[ConservativeMind]

Hundreds of chemical compounds were screened on cell cultures representing different stages and subtypes of bladder cancer and several promising agents with inhibitory (growth-inhibiting) effects were identified. A drug used to treat childhood leukemia was found to have good efficacy in two specific types of bladder cancer.

Shahrokh Shariat and Walter Berger screened various drugs. They investigated the effects of more than 1,700 chemical compounds on 23 commercially available cell lines representing different stages and subtypes of bladder cancer. The scientists were able to identify over 470 substances with inhibitory (growth-inhibiting) effects. These included a large number of drugs already used for cancers and also drugs for treating malaria, parasitic diseases and various mental disorders, for example.

Leukemia drug offers hope in urothelial carcinoma and sarcomatoid carcinoma

One of these compounds, clofarabine, an antimetabolite currently used as a treatment for childhood leukemia, was studied in more detail. For this, the researchers developed models from patient material representing different types of bladder cancer. In addition to "conventional" urothelial carcinomas, they were also able to establish an animal model for sarcomatoid carcinoma. This is a rare subtype of bladder cancer, for which there is currently no effective chemotherapy. "We found that clofarabine induced complete remission in mice with conventional urothelial carcinoma, while in the animals with sarcomatoid carcinomas it led to massive, sustained shrinkage of the tumors without causing any apparent side effects," said first author Iris Ertl.

Use in clinical trials for the treatment of metastatic bladder cancer

Next steps will be clinical trials in which patients with metastatic bladder cancer who, for various reasons, cannot be given cisplatin-based therapy will be given clofarabine prior to radical cystectomy (surgical removal of the urinary bladder.

[ConservativeMind]

This could be used “off label” or as part of “Right-To-Try.”

[ConservativeMind]

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[Chickensoup]

Bump

[oil_dude]

I predict Hydroxychloroquine and Ivermectin are on the list

[Red Badger]

My mother-in-law had bladder cancer and they took half her bladder out...........................

[jimwatx]

“These included a large number of drugs already used for cancers and also drugs for treating malaria, parasitic diseases”

They’ve known for over a decade that anti-parasite drugs like ivermectin have potent anti-cancer effects with minimal side effects, yet because they’re inexpensive generics, big pharma purposely ignored them.

https://duckduckgo.com/?q=pubmed+ivermectn+cancer&atb=v314-1&ia=web