Intense light protects against lung damage (Light, or the orange peel flavonoid “nobiletin,” reduced lung inflammation, improved blood/air barrier & produced antibacterial mucus)

Medical Xpress / CU Anschutz Medical Campus / American Journal of Physiology's Lung Cellular and Mol ^ | Mar. 24, 2022 | David Kelly / Yoshimasa Oyama et al

[ConservativeMind]

Intense light activates proteins shown to protect against lung damage in mice, a discovery that could have major therapeutic implications for treating acute lung injury in humans, according to a new study.

"Acute lung injury has a mortality rate of 40%," said lead author Tobias Eckle, M.D. "No specific therapy exists, and novel treatment options are needed."

Eckle's team, which previously demonstrated that light can protect against cardiovascular disease, housed mice under intense rather than ambient light for seven days. This prompted a strong increase in the trough and peak levels of the pulmonary circadian rhythm protein - Period 2 or PER2.

If the protein was deleted in a specific lung cell known as the alveolar type 2 cell, acute lung injury was fatal. If the protein was not deleted, 85% of the mice survived. Alveolar type 2 cells have long been recognized as playing an important role during acute lung injury but have never been linked to the light regulated protein PER2.

The study also showed that intense light therapy reduced lung inflammation or improved the function of the alveolar barrier – the blood-air barrier - in lung infections. Researchers saw the same reaction when using the flavonoid, nobiletin, found in orange peel, which also enhances the amplitude of PER2.

At the same time, the researchers found that intense light stimulated production of the BPIFB1 protein, known to be anti-bacterial and secreted within the mucus membranes of the large airways. They believe this also likely plays a role in protecting the lungs.

Discovering that intense light can protect against lung damage, Eckle said, is important due to the lack of therapies currently available to treat the condition.

"If you develop lung injury there is essentially no good therapy left," he said.

[ConservativeMind]

The study is only available with a purchase, but I would assume the light was a very bright indoor full-spectrum source, rather than a heat lamp or unprotected sunlight.

Nobiletin is available as a supplement.

[ConservativeMind]

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[Yo-Yo]

Trump was right again.

https://www.businessinsider.com/trump-wants-bring-light-inside-the-body-to-kill-coronavirus-2020-4

[rockabyebaby]

Bump

[21twelve]

A thread last week was talking about how sleeping with the lights on was bad for you! (I know, different types, but still....)

[humblegunner]

Yeah, I’m sure everyone is concerned about antibacterial mucus.

What’s next? Threads about butt rash and crabs?

[Harmless Teddy Bear]

But should you take it or should you inhale it?

[Mazey]

Thank you ConservativeMind for this list. I learn so much, and appreciate the time you put into it.

This article is absolutely fascinating.

[ConservativeMind]

What's next? Threads about butt rash and crabs?

I can look for those, if you are having a problem with them, but I haven't seen any, lately.

[ConservativeMind]

The lights would likely be turned off for night time use.

It helps restart the circadian rhythm in the cells, which should require a no light occasion.

Strangely, another study yesterday or the day before talked about doing this in COPD sufferers, yet a different way.

[Skywise]

Trump says to eat light bulbs!

[thinden]

Circle back on orange

[humblegunner]

So something happened to get you all jazzed up about your antibacterial mucus?

[RandallFlagg]

Cool!
Flaming shots of Bacardi 151 rum, here I come!
I’ll let ya know how it goes.

[ConservativeMind]

For people with bacterial loads in their lungs, of which many people have them, including Cystic Fibrosis sufferers, it’s a constant worry about the infection going out of control.

Here’s an example:

Why one bacterial infection is so deadly in cystic fibrosis patients: Pathogen interferes with cells whose job is to fight infection

https://www.sciencedaily.com/releases/2012/04/120422162413.htm

[ckilmer]

ultra violet light makes vitamin d
infra red light makes melatonin.

They are two bands of the light spectrum.

[humblegunner]

For people with bacterial loads in their lungs, of which many people have them, including Cystic Fibrosis sufferers, it’s a constant worry

Yeah, OK.

Thanks for catching everyone up on all that.

I'm sure there was a pressing need for it.

[Pete from Shawnee Mission]

21 12; Come on man! Its like two genders!!

Intense light in the Daytime while you work! Darkness at night when you have sex and sleep!!

(Or just eat orange peel and do those other things :))

[ptsal]

Post 3
Yep

[TTFX]

infra red light makes melatonin.

- - - - - - -

I think blue light reduces melatonin production. We typically receive blue light from the sun. After sunset, if we make a fire, we receive mostly red light.