Posted on 03/23/2022 4:04:52 PM PDT by ConservativeMind
Indiana University School of Medicine researchers have found that niacin limits Alzheimer's disease progression when used in models in the lab, a discovery that could potentially pave the way toward therapeutic approaches to the disease.
The study investigates how niacin modulates microglia response to amyloid plaques in an Alzheimer's disease animal model.
Gary Landreth, Ph.D., Martin Professor of Alzheimer's Research, and Miguel Moutinho, Ph.D., postdoctoral fellow in Anatomy, Cell Biology and Physiology, led the study.
"This study identifies a potential novel therapeutic target for Alzheimer's disease, which can be modulated by FDA-approved drugs," Moutinho said. "The translational potential of this strategy to clinical use is high."
Niacin, which sustains metabolism throughout the body, is mainly obtained through a typical diet; it also can be taken in supplements and cholesterol-lowering drugs. The brain, however, Moutinho found, uses niacin in a different manner.
In the brain, niacin interacts with a highly-selective receptor, HCAR2, present in immune cells physically associated with amyloid plaques. When niacin—used in this project as the FDA-approved Niaspan drug—activates the receptor, it stimulates beneficial actions from these immune cells, Landreth said.
"After the Alzheimer's disease animal models received niacin, they ended up with fewer plaques and they have improved cognition," Landreth said, "and we directly showed that these actions were due to the HCAR2 receptor."
Past epidemiology studies of niacin and Alzheimer's disease showed that people who had higher levels of niacin in their diet had diminished risk of the disease, Landreth said. Niacin is also currently being used in clinical trials in Parkinson's disease and glioblastoma.
To further their research into niacin and the brain, Landreth and Moutinho are collaborating with Jared Brosch, MD, associate professor of clinical neurology, who is applying for a clinical pilot trial to study the affects of niacin and the human brain.
(Excerpt) Read more at medicalxpress.com ...
Opened my mind..........
Was it Niaspan? Had a friend who used to be a rep for that drug.
Fenchol from basil leaves was recently identified as possibly helpful also.
I predict another study soon talking about how toxic time-released niacin is. After all, this HAS to be a cheap drug, and as everyone knows, we can’t have THAT now can we?
. . . However, this was news . . .
” , ,3) There is a chemical found in quantity in the bodies of schizophrenic persons. It is an indole called adrenochrome.
Adrenochrome (which is oxidized adrenalin) has an almost LSD-like effect on the body. That might well explain their behavior.
Niacin serves to reduce the body’s production of this toxic material. . . .”
The niacin flush is REAL, y’all.
I do appreciate the things you add to the threads, but if you could, try to edit down what you post in long free form.
I spend time editing down my threads to keep thing as easy to read as possible. Long inserts of apparent books with a tables of content is probably best for a thread of its own. A link and brief write up is much more digestible for readers.
They should find something . . . after all, they have a 24/7 lab rat living in the White House that is fully insured.
Sorry. Apologise. Will take care so to do so in future. Thank you for posting these.
Was quite startled at the article’s mention of adrenochrome in schizophrenics.
If all the pizzagate/blood drinking horror rumours about celebrities are true, this would be a viable explanation for their bizarre behaviors.
I agree this post by Norski was quite long, and I am not totally innocent of posting content. What I do with a really long comment of interest is print it for later study. Reading such a post I find easier than doing all the research and information mining included in such a long post. I suspect if someone is really interested they will read it. If not they will skip over it. I am unclear on whether the rest of the comment is from the link given at the beginning. If the rest of the comment pertained to several sources, then perhaps additional links could have been included and somewhat less writing included in the comment.
bkmk
Niacin ping
CM thank you for posting!
Would Benfoetemine work??
Dear Mods:
Please be so kind as to pull this post.
Need to re-post in a shorter format for better use, as per request. Thank you. Norski
Will be reposting in shorter format in future as per post #16.
We do what we can to promote and maintain cordial exchange of information and opinions. Thank you, Norski
I could find nothing that mapped mechanisms of benfotiamine to HCAR2.
However, this supplement appears somewhat close to the one used:
“ENDUR-ACIN Niacin - Vitamin B3 500mg Extended Release & Low-Flush”
The prescription one uses a specific, very slightly different, form of nicotinic acid that in not the standard nicotinic acid, but the general behavior is likely similar.
Of hopeful note to those having loved ones with Alzheimer’s:
“
ALZHEIMER’S DISEASE: NUTRITIONAL THERAPIES
by Andrew W. Saul
First, some very good news:
Niacin halts and reverses Alzheimer’s disease.
The human dose equivalent of 2,000 to 3,000 mg/day of vitamin B3 was given to mice with Alzheimer’s.
One of the researchers reported, “Cognitively, they were cured. They performed as if they’d never developed the disease.”
http://orthomolecular.org/resources/omns/v04n25.shtml
Also see:
Reversal of Alzheimer’s Disease and Optimization of Brain Health with Orthomolecular Medicine, by Benjamin I. Brown, ND. Journal of Orthomolecular Medicine 2019, 34:1. https://isom.ca/article/reversal-alzheimers-disease-optimization-brain-health-orthomolecular-medicine/
Vitamins Help Prevent Alzheimer’s Disease: News Media Ignores Supplement Benefits . . .Again. Orthomolecular Medicine News Service, December 20, 2013 http://orthomolecular.org/resources/omns/v09n30.shtml
Choline
AD patients have a deficiency of the neurotransmitter acetylcholine because they are deficient in the enzyme, choline acetyltransferase, needed to make it. This results in curtailed manufacture and presence of acetylcholine in the brain. But there is a way around this: increasing dietary choline raises blood and brain levels of acetylcholine. Choline is readily available in cheap, non-prescription lecithin.
A large quantity of choline (from lecithin) is necessary for clinical results. Lecithin is non-toxic. [Little, et al (1985) A double-blind, placebo controlled trial of high dose lecithin in Alzheimer’s disease. J Neurology, Neurosurgery and Psychiatry, 48: 736-742.]
The usual cautions about adding niacin if you are taking statins. An interaction can cause increased risk of rhabdomyolysis, but minimally with smaller niacin doses.
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