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Ivermectin effect in COVID-19 varies with strongyloidiasis prevalence (Reduced proportionate death much more among roundworm-infected locales)
Medical Xpress / Icahn School of Medicine at Mount Sinai / JAMA Network Open ^ | Mar. 23, 2022 | Avi Bitterman et al

Posted on 03/23/2022 2:56:36 PM PDT by ConservativeMind

In trials of ivermectin as a treatment for COVID-19, the relative risk of mortality varies with strongyloidiasis prevalence, according to research published online March 21 in JAMA Network Open.

Avi Bitterman, M.D., from the Icahn School of Medicine at Mount Sinai in New York City, and colleagues examined the association between regional prevalence of strongyloidiasis and ivermectin trial results for the outcome of mortality in a meta-analysis of randomized clinical trials using ivermectin as a treatment for COVID-19. Data were included from 12 trials, with 3,901 patients: four and eight trials took place in regions of high and low strongyloidiasis prevalence, respectively.

The researchers found that there was no significantly decreased risk of mortality in ivermectin trials that took place in areas of low regional strongyloidiasis prevalence (relative risk, 0.84; 95 percent confidence interval, 0.60 to 1.18; P = 0.31). In contrast, a significantly decreased risk of mortality was seen in ivermectin trials that took place in areas of high regional strongyloidiasis prevalence (relative risk, 0.25; 95 percent confidence interval, 0.09 to 0.70; P = 0.008). The difference between the results of groups with low and high strongyloidiasis prevalence was significant. For each 5 percent increase in strongyloidiasis prevalence, meta-regression analysis revealed a decrease of 38.83 percent in relative risk.

"Results of ivermectin trials in strongyloidiasis-endemic regions may not extrapolate to strongyloidiasis-nonendemic regions," the authors write. "Future trials in nonendemic regions may provide insight into the true effect of ivermectin in this context. In the interim, we strongly caution against extrapolation for patients not at increased risk for strongyloidiasis."

(Excerpt) Read more at medicalxpress.com ...


TOPICS: Health/Medicine
KEYWORDS: covid; covid19; ivermectin; ivermectinstudy
It’s not clear why from the write up, but it seems to me that either Ivermectin abolished both infections, saving those more likely to die, or maybe an infection factor in which being infected with roundworms tamped down the immune system (known to happen from worm infections) to allow ivermectin to work without the possible immune system overreaction that COVID sufferers sometime get

Interesting.

1 posted on 03/23/2022 2:56:36 PM PDT by ConservativeMind
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To: Pete from Shawnee Mission; Mazey; ckilmer; goodnesswins; Jane Long; BusterDog; jy8z; ...

The “Take Charge Of Your Health” Ping List

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2 posted on 03/23/2022 2:57:42 PM PDT by ConservativeMind (Trump: Befuddling Democrats, Republicans, and the Media for the benefit of the US and all mankind.)
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To: ConservativeMind

Bkmi


3 posted on 03/23/2022 3:01:30 PM PDT by ptsal (Vote R.E.D. >>>Remove Every Democrat ***)
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To: ConservativeMind

I have heard people saying this for over a year, that ivermectin can clear parasite infections that suppress the immune system. Effectively, it cures a comorbidity, not COVID itself.


4 posted on 03/23/2022 3:44:18 PM PDT by ETCM
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To: ConservativeMind

ConservativeMind wrote: “It’s not clear why from the write up, but it seems to me that either Ivermectin abolished both infections, saving those more likely to die,...”

Or perhaps the ivermectin suppressed the worms resulting in a better health perspective. IOW, ivermectin didn’t do a thing for the COVID but it did kill off the worms. This would be consistent with those without a worm infection showing no improvement.


5 posted on 03/23/2022 4:11:16 PM PDT by DugwayDuke (Most pick the expert who says the things they agree with.)
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To: ConservativeMind

Having posted previously on links found between parasite infestation, particularly ascaris and roundworm and asthma, and also parasite infestation and cancer, particularly colon cancer, this makes sense.

Researcher Hulda Clark found the above and wrote six books on the subject, healing from these.


6 posted on 03/23/2022 4:14:44 PM PDT by Norski
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To: ConservativeMind
If anyone is interested, ValleyVet has the 1.87% horse paste for sale again.

https://www.valleyvet.com/ct_detail.html?pgguid=4D9A49D8-394F-46B3-883C-733D88C2C257

7 posted on 03/23/2022 4:24:46 PM PDT by TangoLimaSierra (⭐⭐Public hangings will wake 'em up.⭐⭐)
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To: ConservativeMind

Bkmk


8 posted on 03/23/2022 7:04:23 PM PDT by sauropod (Whom the gods would destroy they first make mad.)
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To: TangoLimaSierra

Jeffers has some for $6.99.


9 posted on 03/23/2022 7:49:31 PM PDT by Pete from Shawnee Mission
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To: ConservativeMind

Interesting, indeed. Is it possible that people in areas with high prevalence of strongyloidiasis have been on ivermectin for many years? Perhaps it is the amount of time you’ve been on ivermectin that created high serum levels as opposed to people who took it only when they got sick and didn’t have the same serum levels.


10 posted on 03/23/2022 8:13:36 PM PDT by ProtectOurFreedom (“Today I will do what others won't, so tomorrow I can accomplish what others can't.” ~ Jerry Ri)
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To: Pete from Shawnee Mission
Jeffers has some for $6.99.

Actually, they are still saying it is unavailable.

11 posted on 03/24/2022 5:32:33 AM PDT by TangoLimaSierra (⭐⭐Public hangings will wake 'em up.⭐⭐)
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To: ETCM
Ivermectin is an anthelmintic, but it also has antiviral properties.

Ivermectin: an award-winning drug with expected antiviral activity against COVID-19

12 posted on 03/24/2022 5:36:09 AM PDT by mewzilla (We need to repeal RCV wherever it's in use and go back to dumb voting machines.)
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To: ConservativeMind

How about the other factors, such as clinical trials in low prevalence regions having been those designed to fail (e.g., with low dosage)?

Just like the HCQ trial scams, I bet.


13 posted on 03/24/2022 5:40:11 AM PDT by 9YearLurker
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To: TangoLimaSierra

I must have hit them at the right time. They show unavailable now.


14 posted on 03/24/2022 8:47:34 AM PDT by Pete from Shawnee Mission
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