How sugar promotes inflammation (Excess glucose influences proinflammatory genes in T helper cells, encouraging autoimmune disorders)

Medical Xpress / University of Würzburg / Cell Metabolism ^ | Mar. 22, 2022 | Sophia M. Hochrein et al

[ConservativeMind]

People who consume sugar and other carbohydrates in excess over a long period of time have an increased risk of developing an autoimmune disease. In affected patients, the immune system attacks the body's own tissue.

Their work (shows) excessive consumption of glucose directly promotes the pathogenic functions of certain cells of the immune system and that, conversely, that a calorie-reduced diet can have a beneficial effect on immune diseases. Based on these findings, they also identified new targets for therapeutic interventions: A specific blockade of glucose-depended metabolic processes in these immune cells can suppress excessive immune reactions.

Martin Väth explains that "immune cells need large amounts of sugar in the form of glucose to perform their tasks. With the help of specialized transporters at their cell membrane, they can take up glucose from the environment." Väth has showed that a specific glucose transporter—scientifically named GLUT3—fulfills additional metabolic functions in T cells besides the generating energy from sugar.

The scientists focused on a group of cells of the immune system that have not been known for very long: T helper cells of type 17, also called Th17 lymphocytes, which play an important role in regulating (auto-) inflammatory processes.

"These Th17 cells express lots of GLUT3 protein on their cell surface," Väth explains. Once taken up, glucose is readily converted to citric acid in the mitochondria before it is metabolized into acetyl-coenzyme A (acetyl-CoA) in the cytoplasm. Acetyl-CoA is involved in numerous metabolic processes, including the biosynthesis of lipids.

However, acetyl-CoA fulfills additional functions in inflammatory Th17 cells. Väth and his team showed that this metabolic intermediate can also regulate the activity of various gene segments. Thus, glucose consumption has a direct influence on the activity of proinflammatory genes.

[ConservativeMind]

We may now finally understand how excess carbs can cause autoimmune disease.

[ConservativeMind]

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[Safrguns]

OH!... What a relief!!!... and here everyone was worried that it was these safe and effective gene therapy injections which were responsible for all the recent AIDS symptoms.

It was Sugar Carbs all all along!!!

[Beowulf9]

I’m (((doomed)))

[Seruzawa]

Dang. No more pound bags of M&M Peanuts in one sitting?

[RummyChick]

I recently met a 100 year old woman. She walked on her own.

Could carry on a conversation with no problem.

She puts sugar on everything. Does not have diabetes. The person with her said she buys sugar in big bags.

I was flabbergasted at the whole thing. Obviously good genes because her sibling lived to almost 100.

[tunedin]

My grandma lived to 91 with similar experience.I plan to do the dame, or at least die with a smile on my face.

[tunedin]

My grandma lived to 91 with similar experience.I plan to do the same, or at least die with a smile on my face.

[Salvavida]

These Klondike bars are the bomb.

[NetAddicted]

Meh.

[goodnesswins]

Some people are like that...my MIL lived to 94...she ate carbs and sugar...oh, and never exercised

[TTFX]

Sugar is healthy. People should make the obvious conclusion from their observations.

Some peopme have problems processing sugar. It would be good to find out why. Healthy people benefit from consuming sugar.

[JimRed]

People who consume sugar and other carbohydrates in excess over a long period of time...

OK, so how much is "in excess" and for how long a period of time?

[JimRed]

Dang. No more pound bags of M&M Peanuts in one sitting?

My favorites! But I limit it to a short handful at a sitting- usually about 12-15 of them. Even better were the M&M Peanuts in dark chocolate that were around for a short while but disappeared.

[Seruzawa]

OK, so how much is “in excess”

More than your mom says!

[TTFX]

OK, so how much is “in excess” and for how long a period of time?

- - - - - - -

I believe the feeling of satiation is a good guide.

Once you consume the ideal amount of sugar you feel you don’t want it anymore. Since people stop at this point, excess consumption of sugar almost never happens.

To process sugar we need vitamins. Fruits contain these. Some people don’t consume fruits or nutritous foods so they might not be able to process the sugar they consume.