Skip to comments.When fossils come to life: SARS-CoV-2 spike, syncytin-1, and other curious fusion proteins
Posted on 02/08/2022 4:38:05 PM PST by BenLurkin
The homotrimeric spike glycoprotein (S) from SARS-CoV-2, particularly its S2 subunit, is a fusion protein extraordinaire. It can fuse viral particles to cells and also fuse cells to cells to create multifarious syncytia among different cell phenotypes. Depending on which exact versions are under consideration, the spike can perform these feats via multiple mechanisms acting at both the intracellular and extracellular sides of cell membranes.
These fusion functions are somewhat analogous to typical homotrimeric ENV (envelope) proteins like our syncytin-1 endogenous retroviral ENV protein, and the GP160 ENV glycoprotein from the HIV virus. GP160, the HIV 'spike' protein, is ultimately processed at its own furin cleavage site (also found in syncytin-1) into a GP120 and a GP41 protein, both of which can adopt distinct pre- and post-fusion configurations. The SARS-CoV-2 genome, however, already specifies a separate small ENV protein (conveniently designated as E), which assembles into a presumptive cation channel with a central fusion pore.
There are no env, pol, gag, or pro genes defined as such for the SARS-CoV-2 genome, as is the case for the retroviruses, which must integrate into our DNA as part of their lifecycle. Curiously, researchers have found that the SARS-CoV-2 spike protein, behaving of its own accord, directly participates in the activation of endogenous retroviruses in our cells which contributes to observed pathology.
(Excerpt) Read more at phys.org ...
It’s not just Fauci and deep state who spew BS and nonsense.
There’s nothing of substance to show as false.
It’s random statements and assertions.
These are the two important paragraphs, as they detail how such large clots are formed in some Covid (or even vax induced as these clots are a function of the spike protein) victims:
But enough of this fear-mongering. Researchers have identified a set of already approved drugs that prevent spike-induced cell fusion and inhibit TMEM16F, a critical protein for syncytium formation. TMEM16F has the dual role of being a calcium-activated ion channel that regulates chloride secretion, as well as a lipid scramblase that relocates phosphatidylserine (PS) to the cell surface. This PS externalization is required for cell fusion in many systems, including spike-induced syncytia. Incidentally, scramblases also control the rate-limiting steps of the blood coagulation cascade, and may be the mechanism behind spike-induced thrombosis.
The blood coagulation pathways are a whole separate complex can of worms, but suffice it to say here that the primary trigger of coagulation induced by viral infections is the so-called extrinsic 'tenase.' Tenases are enzymes that process Factor X, or FX, (hence ten-ase), in the Tissue Factor (TF) activation pathway, which essentially act as the fuse for thrombus generation. The resulting complexes are assembled on externalized PS in the presence of calcium ions. TF is, in a sense, encrypted and so is unable to activate its downstream target factor FVIIa until it is de-encrypted by externalized PS.
You may find this interesting.
I responded to the excerpt.
I cannot read the article.
I am familiar with Phys.org.
No need for your insults which show a bad faith as bad as you accuse me of.
I’ll read your post and respond.
“Can you point out any particular parts which are demonstrably false?”
The parts he doesn’t want to believe, of course.
“blood coagulation pathways are a whole separate complex can of worms”
You said it.
This is a hodgepodge of biochemical recitations that are not particularly coherent in making any point.
As you rightly state above, syncytial formation, that pretty much any virus can cause, has little if nothing to do with coagulation.
Activation of innate immune system triggers many effects including coagulation.
Single stranded RNA is an activator of this system and the vaccines are of course single stranded RNA.
If there is a real scientific article about what point is trying to make point me to it.
What this article does is to show how very dangerous is the Coronavirus spike protein, which is the basis of COVID vaccines. It is not yet time to push the panic button, because vaccines, such as Pfizer’s, is mRNA coding for only small PARTS of the spike protein. Still, the article shows how spike-based vaccines are messing with potentially dangerous biological material.
“What this article does is to show how very dangerous is the Coronavirus spike protein...”
But it doesn’t.
And spike protein paranoia is Fauci level fear mongering.
And btw, the vaccines code for all the spike protein. Not just small parts of it.
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