WHAT DOES THE GRAPEFRUIT WARNING ON MY CBD MEAN?

Lazarus Naturals ^ | 1-27-11 | Unlisted

[RummyChick]

i like martha stewart gummies. I have no idea if they do any good but I eat them anyway.

[Myrddin]

Grapefruit inhibits cytochrome P450. See Grapefruit–medication interactions: Forbidden fruit or avoidable consequences?. Drug doses are calculated with the expectation that P450 is going to degrade a specific amount of the drug before it can be used. Consuming grapefruit knocks out P450 and the undegraded dose may be an overdose.

[RummyChick]

Do you have any idea how grapefruit interacts with the adrenal genetic variations. Seems like I remember p450 being involved with one of the Adrenal Hyperplasia issues

[ex91B10]

Sertraline also has a warning about Grapefruit products.

[RummyChick]

its called:

cytochrome P450 oxidoreductase deficiency

good luck getting Drs to check to figure exactly what you have. I was just told -oh hey..you have adrenal hyperplasia...nothing we can do about it.

[JimRed]

So, get a prescription for the dose of med that will increase to your desired dosage when you have your grapefruit or juice. Win-win.

[Myrddin]

So, get a prescription for the dose of med that will increase to your desired dosage when you have your grapefruit or juice. Win-win.

You misunderstood the effect of inhibiting P450. If the intended "net" dose of a medication is 50 mg, the actual dose provided will be 100 mg assuming the P450 will degrade half of the dosage provided. If you consume grapefruit juice, the P450 is inactivated. The 100 mg dose arrives undegraded. You have just overdosed by a factor of 2x.

[JimRed]

You misunderstood the effect of inhibiting P450.

Not the first thing I've misunderstood! Thanks.