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SARS-CoV-2 spike protein binds to heart's vascular cells, potentially contributing to severe microvascular damage (Spike protein alone causes dysfunction, but not the full virus w/spike!)
Medical Xpress / University of Bristol / Clinical Science ^ | Feb. 3, 2022 | Elisa Avolio et al

Posted on 02/03/2022 6:10:08 PM PST by ConservativeMind

A study has shown how SARS-CoV-2 may contribute to severe microvascular damage seen in severely-ill COVID-19 patients by transforming human heart vascular cells into inflammatory cells, without infecting them. The research indicates blocking antibodies could represent a new treatment to alleviate cardiovascular complications.

Until now, it remained unclear whether heart cells are infected by the virus or damaged because of an excess cytotoxic defense response. This response, known as 'the cytokine storm', comes from our immune cells, whereby cytotoxic cells attack and kill the infected cells by releasing proteins, called cytokines.

A team exposed human heart pericytes, which are cells that wrap small blood vessels in the heart, to SARS-CoV-2 Alpha and Delta variants, along with the original Wuhan virus. Surprisingly, they found the heart pericytes were not infected.

Intrigued by this finding, in a second test-tube experiment, the researchers challenged the cardiac pericytes with the spike protein alone, without the virus. The spike protein made pericytes unable to interact with their companion endothelial cells and induced them to secrete inflammatory cytokines, suggesting the spike protein is harmful to human cardiac cells. Interestingly, the team found that antibodies blocking CD147—a receptor for the spike protein—protected heart pericytes from damage.

Finally, the team identified the presence of the SARS-CoV-2 spike protein in blood samples obtained from COVID-19 patients, which opens the possibility that spike protein particles traveling through the circulation can cause systemic damage.

Dr. Elisa Avolio said that "pericytes are essential cells of the heart, although their role in maintaining the structural integrity of the coronary vascular tree has emerged only recently. Our research indicates these cells co-operate with coronary endothelial cells. This shows the spike protein jeopardizes this interaction and transforms pericytes into inflammatory cells. Hopefully, CD147 blocking antibodies could alleviate cardiovascular complications in COVID-19 patients."

(Excerpt) Read more at medicalxpress.com ...


TOPICS: Health/Medicine
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This appears to show vaccines with only the spike protein, or those that cause our bodies to make the spike protein, can cause some heart cells to become dysfunctional.

If the actual virus infects someone, the damage does not happen until the spike protein appears to become decoupled from the rest of the virus.

Who would have thought getting the actual virus could be safer for the heart?

1 posted on 02/03/2022 6:10:08 PM PST by ConservativeMind
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To: Pete from Shawnee Mission; Mazey; ckilmer; goodnesswins; Jane Long; BusterDog; jy8z; ...

The “Take Charge Of Your Health” Ping List

This potentially high volume ping list is for health articles and studies which describe something you or your doctor, when informed, may be able to implement for your benefit.

Please email or private message me if you want on or off of this list.

2 posted on 02/03/2022 6:10:43 PM PST by ConservativeMind (Trump: Befuddling Democrats, Republicans, and the Media for the benefit of the US and all mankind.)
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To: ConservativeMind
Who would have thought getting the actual virus could be safer for the heart?

Pro tip: It isn't.

3 posted on 02/03/2022 6:15:10 PM PST by Jim Noble (The nation cannot be saved until the GOP is destroyed)
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To: Jim Noble
Pro tip: It isn't

Exactly, I have non-ischemic cardiomyopathy from some virus I picked up over 10 years ago.

4 posted on 02/03/2022 6:25:44 PM PST by 11th_VA (I can still remember an America where dissent was the highest form of patriotism.)
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To: ConservativeMind; ransomnote; Cathi; metmom; grey_whiskers; bagster; tatown; Enlightened1; cgbg; ...

Who would have thought getting the actual virus could be safer for the heart?


Well, anyone who’s been listening to Dr Peter McCullough, for the past year.

He’s told us just this.

It’s the Faucists and $hot $hills who’ve insisted, otherwise.


5 posted on 02/03/2022 6:33:40 PM PST by Jane Long (What we were told was a “conspiracy theory” in 2020 is now fact. 🙏🏻 Ps 33:12)
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To: 11th_VA

The pericytes may not be related at all with your issue.

This is strictly on a new issue found with a newer relationship between these cells and endothelial cells.


6 posted on 02/03/2022 6:33:42 PM PST by ConservativeMind (Trump: Befuddling Democrats, Republicans, and the Media for the benefit of the US and all mankind.)
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To: ConservativeMind; Jane Long; ransomnote

It has been apparent from the beginning that the Baric-Daszak-Fauci spike protein, by itself, is deadly.

The poisons called COVID vaccines flood the systems of the people who get them with a version of the Baric-Daszak-Fauci spike protein.

Therefor, the poisons called COVID vaccines are deadly.


7 posted on 02/03/2022 6:39:53 PM PST by Arcadian Empire (The Baric-Daszak-Fauci spike protein, by itself, is deadly.)
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To: ConservativeMind

I don’t know which cells were affected. But I learned that viruses can attack organs inside your body - not just give you the flu


8 posted on 02/03/2022 6:43:47 PM PST by 11th_VA (I can still remember an America where dissent was the highest form of patriotism.)
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To: Arcadian Empire

Why aren’t more vaccinated people showing signs of degeneration or illness?


9 posted on 02/03/2022 7:12:45 PM PST by BipolarBob (The roar of the masses could be "Let's Go Brandon".)
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To: Jim Noble

Ah, the 3rd shifters are here


10 posted on 02/03/2022 8:05:47 PM PST by roving (Vaxxers Suddenly Eager To Be Pro-Choice)
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To: BipolarBob

This clip from Steven K. Bannon’s War Room pandemic from tonight with Drs. Navaro and Malone discussing the DOD army data.

https://americasvoice.news/video/muLxCWZVzomijJE


11 posted on 02/03/2022 11:10:53 PM PST by Freedom56v2 (It's not the job of the unvaxxed to protect the vaxxed. That's the job of the "vaccine.")
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To: ConservativeMind
The article never mentions the vaccine. The title is misleading. The stuff in parenthesis doesn't exist in the original article.

It's strictly about the virus and the spike proteins being found in the blood of covid patients.

"Professor Paolo Madeddu, cardiologist and the study lead from the University's Bristol Medical School, added that "microvascular complications are frequent and harmful in patients with COVID-19, with up to 11 percent of those hospitalized in intensive care units having myocardial damage or having suffered a heart attack. Furthermore, people with pre-existing cardiovascular diseases are more likely to die of COVID-19."

12 posted on 02/04/2022 1:52:52 AM PST by DannyTN
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To: DannyTN
“The title is misleading. The stuff in parenthesis doesn't exist in the original article.”

From the title (the words in parenthesis):

(Spike protein alone causes dysfunction, but not the full virus w/spike!)

From the article:

A research team exposed human heart pericytes to SARS-CoV-2 Alpha and Delta variants, along with the original Wuhan virus…the heart pericytes were not infected.

…the researchers challenged the cardiac pericytes with the spike protein alone, without the virus. The spike protein made pericytes unable to interact with their companion endothelial cells and induced them to secrete inflammatory cytokines.

The team identified the presence of the SARS-CoV-2 spike protein in blood samples obtained from COVID-19 patients, which opens the possibility that spike protein particles traveling through the circulation can reach a site distant from the respiratory system and cause systemic damage.

DannyTN, my comment exactly describes these three paragraphs.

13 posted on 02/04/2022 4:45:39 AM PST by ConservativeMind (Trump: Befuddling Democrats, Republicans, and the Media for the benefit of the US and all mankind.)
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To: ConservativeMind

Oh you’re right. Somehow I read vaccine in your comment.

That third paragraph implies that they found spike protein “alone” in the blood of covid patients. Otherwise the article doesn’t make sense and they wouldn’t have seen heart inflamation in covid patients.

Which means both the Virus and the vaccine are generating spike proteins alone. However I think Moderna was generating 19% of the virus, where Pfizer was generating 2%.

So it would be interesting to see a comparison of how much spike protein “alone” is generated in the blood stream by Covid, Moderna, and Pfizer.


14 posted on 02/04/2022 8:05:20 AM PST by DannyTN
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To: ConservativeMind
This appears to show vaccines with only the spike protein, or those that cause our bodies to make the spike protein, can cause some heart cells to become dysfunctional. If the actual virus infects someone, the damage does not happen until the spike protein appears to become decoupled from the rest of the virus.

Who would have thought getting the actual virus could be safer for the heart?

Wait a second. You didn't say "Vaccine" in your title parenthesized comment. But you said it big time in post #1.

You even go on to claim the virus is safer for the heart than the vaccine! But the article doesn't talk about the vaccine at all and never makes the comparison.

The article claims an 11% risk of heart inflammation for covid. So what's the risk of heart inflammation for vaccines?

The initial claim was that the vaccine would stay in the arm. Clearly that's not the case. But I wonder if post vaccine behavior impacts that. For that reason when I got the vaccines, I took off work and remained largely immobile for 24 hours.

15 posted on 02/04/2022 8:10:30 AM PST by DannyTN
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To: DannyTN
The vaccines either provide the spike protein, or cause cells to make it. It seems only the Sinovac vaccine uses the full virus.

I am not “anti-vax,” but it is logically obvious that one can only get a vaccine-induced injury if they get the vaccine.

I believe people with severe comorbidities, or persons unwilling to at least be prepared for COVID-19 infection with supplements and/or medicines, should consider getting the vaccine, and have always maintained this.

The paper behind that study writeup does reference a paper that specifically speaks about the spike from vaccines, but this study is careful to not pull the word “vaccine” into the body of its study. In my humble opinion, it is due to fear it wouldn't get published if it used such a word.

So you are correct, in that in my first post and not the title, I have the courage to state the obvious—that the most common source of strict spike proteins, vaccines, are the only initial way anyone gets “only spike proteins” into their bodies. Science and definitions of the vaccines prove my assertion, with which I believe you would agree.

16 posted on 02/04/2022 8:28:06 AM PST by ConservativeMind (Trump: Befuddling Democrats, Republicans, and the Media for the benefit of the US and all mankind.)
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To: ConservativeMind

I don't agree with the comment "vaccines, are the only initial way anyone gets “only spike proteins” into their bodies." You seem to be trying to qualify that with the word "Initial", but either covid patients end up with isolated spike proteins or not. And if not, according to the thread article they wouldn't be getting heart inflammation.

The thread article claims 11% of covid patients were showing heart inflammation. The link above claims the risk of heart inflammation is only 15 out of 2.3 million cases or 0.00065% for the vaccine.

Admittedly, there could be problems in the comparison. The 11% is probably covid patients admitted to the hospital. So the risk is lower considering how many were never hospitalized. And the 15 vaccinated with heart inflammation are only those with symptoms severe enough to be evaluated, so there could a lower detection rate in vaccinated vs hospitalized with covid. But 11% in covid vs 0.00065% in vaccinated is an absolutely HUGE gap to overcome through detection rates alone.

I'm aware that Dr. Peter McCullough is claiming that there is more inflammation in young people from the vaccine than from covid. And that it's due to the nanoparticles. But until I see apples to apples comparisons, the vaccine looks a lot safer than covid.

17 posted on 02/04/2022 8:58:46 AM PST by DannyTN
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To: DannyTN
Well, from Factcheck.org clearly states this, in my defense:

“We found we could detect extremely low concentrations of S1 (a subunit of spike) in 11 of 13 healthy vaccinated individuals and the full spike in 3 of 13,” he said in an email, noting that the technology they used is 1,000 times more sensitive than a typical antigen test, “so we are really detecting minute quantities of the spike and S1 proteins.” (Emphasis is his).

https://www.factcheck.org/2021/07/scicheck-covid-19-vaccine-generated-spike-protein-is-safe-contrary-to-viral-claims/

It is unequivocal that even healthy vaccinated people who have never had COVID-19, but were vaccinated, are shedding all or part of the spoke protein. Whether or not it made healthy people sick is a completely different issue. According to the source FactCheck.org used to describe the spikes in circulation, HEALTHY PEOPLE had an 85% chance of finding partial spike proteins and a 23% chance of having full, complete spikes in their blood, in the months after they were vaccinated.

I never stated, in any form, that ultimate safety of vaccines vs COVID was in scope. I have only spoken to the scope of this study.

18 posted on 02/04/2022 9:25:05 AM PST by ConservativeMind (Trump: Befuddling Democrats, Republicans, and the Media for the benefit of the US and all mankind.)
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To: ConservativeMind
I'm not sure how that is a defense at all.

And you clearly said "Who would have thought getting the actual virus could be safer for the heart?"

You made the comparison, the article didn't.

19 posted on 02/04/2022 9:37:24 AM PST by DannyTN
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To: DannyTN

The viral infection starts with only whole viruses. These cannot cause this pericyte issue.

The vaccines start with only spikes, which either continue to be made in the body for months, or for which our bodies seemingly cannot fully stop, once in circulation. Only spikes cause the pericyte issue.

It’s a completely straightforward explanation.


20 posted on 02/04/2022 9:51:27 AM PST by ConservativeMind (Trump: Befuddling Democrats, Republicans, and the Media for the benefit of the US and all mankind.)
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