Posted on 01/26/2022 2:59:40 PM PST by ConservativeMind
An international research team has established a link between gut microbiota and chronic inflammatory diseases such as arthritis. The team has discovered that a protein naturally present in the gut acts on the microbiota and causes the formation of molecules that exacerbate the symptoms of these diseases.
The protein in question, phospholipase A2-IIA, was discovered several years ago in the fluid that surrounds the joints of people with arthritis according to Dr. Boilard. The protein was subsequently detected elsewhere in the body, notably in the gut where it is produced in abundance.
"It took a long time before we realized that it exhibits antibacterial activity," said Dr. Boilard. "The protein interacts little with the membrane of human cells, but it has high affinity for bacterial membranes. It binds to these membranes and splits them, releasing small molecules such as fatty acids."
The researchers used transgenic mice. "These mice have the human gene that codes for phospholipase A2-IIA," explained the researcher. "As they age, they spontaneously JCI Insight develop manifestations of chronic systemic inflammation."
Experiments revealed that phospholipase alters the profile of bacterial lipids that end up in the gut. "By releasing fatty acids from bacterial membranes, the protein produces proinflammatory lipids that exacerbate chronic inflammation and increase the severity of arthritis symptoms in these mice," summed up Dr. Boilard.
In another article published simultaneously, Japanese researchers demonstrated that the action of phospholipase on the gut microbiota of mice also affects psoriasis, another inflammatory disease, as well as skin cancer.
These breakthroughs could have therapeutic implications. "The work of both teams suggests that local inhibition of phospholipase may alleviate the inflammatory process that exacerbates certain diseases. It also suggests that blocking the bacterial proinflammatory lipids produced in the gut by this protein could reduce symptoms in people with systemic inflammatory diseases.”
(Excerpt) Read more at medicalxpress.com ...
Some treatment options listed in this:
The need for Group IIA secretory phospholipase A2 (sPLA2-IIA) inhibitors in inflammatory ocular disease treatment
so this is about Rheumatoid arthritis not osteoarthritis?
I just noticed an easy, safe one from the list: Fucoidan.
I’ve been taking fucoidan for the past several months. I’ve not had any issues with it.
Correct.
Is Osteo the form of arthritis you are concerned about?
“CHINESE WEED”
“Cool, man!” - Chong
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Oleanolic acid - thats in olive oil. I’d up my intake of that rather than using f brandon.
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