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NIH National Library of Medicine: Therapies to Prevent Progression of COVID-19, Including Hydroxychloroquine, Azithromycin, Zinc, and Vitamin D3 With or Without Intravenous Vitamin C: An International, Multicenter, Randomized Trial
CUREUS: NIH National Library of Medicine: National Center for Biotechnology Information ^ | 11/25/2021 | Karin Ried, Taufiq BinJemain ,and Avni Sali

Posted on 01/20/2022 8:41:23 PM PST by SeekAndFind

Abstract

Background

COVID-19 is a global pandemic. Treatment with hydroxychloroquine (HCQ), zinc, and azithromycin (AZM), also known as the Zelenko protocol, and treatment with intravenous (IV) vitamin C (IVC) have shown encouraging results in a large number of trials worldwide. In addition, vitamin D levels are an important indicator of the severity of symptoms in patients with COVID-19.

Objectives

Our multicenter, randomized, open-label study aimed to assess the effectiveness of HCQ, AZM, and zinc with or without IVC in hospitalized patients with COVID-19 in reducing symptom severity and duration and preventing death.

Methods

Hospitalized patients with COVID-19 in seven participating hospitals in Turkey were screened for eligibility and randomly allocated to receive either HCQ, AZM, and zinc (group 1) or HCQ, AZM, zinc plus IV vitamin C treatment (group 2) for 14 days. The patients also received nontherapeutic levels of vitamin D3.

The trial is registered on the Australian and New Zealand Clinical Trial Registry ACTRN12620000557932 and has been approved by the Australian Therapeutic Goods Administration (TGA).

Results

A total of 237 hospitalized patients with COVID-19 aged 22-99 years (mean: 63.3 ± 15.7 years) were enrolled in the study. Almost all patients were vitamin D deficient (97%), 55% were severely vitamin D deficient (<25 nmol/L) and 42% were vitamin D deficient (<50 nmol/L); 3% had insufficient vitamin D levels (<75 nmol/L), and none had optimal vitamin D levels.

Of the patients, 73% had comorbidities, including diabetes (35%), heart disease (36%), and lung disease (34%).

All but one patient (99.6%; n = 236/237) treated with HCQ, AZM, and zinc with or without high-dose IV vitamin C (IVC) fully recovered. Additional IVC therapy contributed significantly to a quicker recovery (15 days versus 45 days until discharge; p = 0.0069).

Side effects such as diarrhea, nausea, and vomiting, reported by 15%-27% of the patients, were mild to moderate and transient. No cardiac side effects were observed.

Low vitamin D levels were significantly correlated with a higher probability of admission to the intensive care unit (ICU) and longer hospital stay.

Sadly, one 70-year-old female patient with heart and lung disease died after 17 days in ICU and 22 days in the hospital. Her vitamin D level was 6 nmol/L on admission (i.e., severely deficient).

Conclusions

Our study suggests that the treatment protocol of HCQ, AZM, and zinc with or without vitamin C is safe and effective in the treatment of COVID-19, with high dose IV vitamin C leading to a significantly quicker recovery.

Importantly, our study confirms vitamin D deficiency to be a high-risk factor of severe COVID-19 disease and hospitalization, with 97% of our study’s patient cohort being vitamin D deficient, 55% of these being severely vitamin D deficient, and none had optimal levels.

Future trials are warranted to evaluate the treatment with a combination of high-dose vitamin D3 in addition to HCQ, AZM, and zinc and high-dose intravenous vitamin C.

CLICK ON THE ABOVE STUDY LINK FOR THE DETAILS



TOPICS: Health/Medicine; Science; Society
KEYWORDS: covid; covid19; covidinfo; hcq; hydroxychloroquine; therapy
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bmfl


21 posted on 01/21/2022 6:36:45 AM PST by Moltke (Reasoning with a liberal is like watering a rock in the hope to grow a building.)
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To: Jane Long

Now that the NIH proved that hcq is safe and effective, doesn’t that eliminate the emergency authorization for the vaccines?


22 posted on 01/21/2022 7:19:14 AM PST by CottonBall (Nothing says 81 million votes like spontaneous “Let's Go Brandon” chants in stadiums all over the US)
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To: CottonBall

Sure would seem so.

Well, until FRAUDci “takes care of” this study and its organizers, probably. :-(


23 posted on 01/21/2022 7:40:04 AM PST by Jane Long (What we were told was a “conspiracy theory” in 2020 is now fact. 🙏🏻 Ps 33:12 )
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To: Jane Long

Good point.

It is dangerous to go against the little Dr. Mengele


24 posted on 01/21/2022 7:42:58 AM PST by CottonBall (Nothing says 81 million votes like spontaneous “Let's Go Brandon” chants in stadiums all over the US)
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To: Ceebass

Docs should have lobbied for payment. ..good vit D levels PREVENT many problems. It’s idiotic NOT to make D a required, paid for test...they do in one of the Scandinavian countries if I remember right.


25 posted on 01/21/2022 8:10:45 AM PST by goodnesswins (....pervert Biden & O Cabal are destroying America, as planned.)
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To: SeekAndFind
I was at the pharmacy the other day and the pharmacist said "Any questions?" On my antibiotic prescription.

\/\/ayne: "If I had a prescription for Ivermectin, would you fill it?"

Pharmacist: "If we could get it I would. They are blocking it from us."

The pharmacist then turned away quickly to attend to something.
26 posted on 01/21/2022 8:16:49 AM PST by \/\/ayne (I regret that I have but one subscription cancellation notice to give to my local newspaper)
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To: goodnesswins

First time I’ve seen report of being vitamin D deficient if under 75!!!

- - - - - - -

Different units.


27 posted on 01/21/2022 8:20:04 AM PST by TTFX ( )
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To: \/\/ayne

Last spring our pharmacy filled Rx for Ivermectin. But they questioned my wife’s doctor about her HCQ prescription. She has been taking HCQ daily for decades.


28 posted on 01/21/2022 8:38:49 AM PST by gitmo (If your theology doesn't become your biography, what good is it?)
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To: TTFX

Not on our tests...


29 posted on 01/21/2022 8:53:41 AM PST by goodnesswins (....pervert Biden & O Cabal are destroying America, as planned.)
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To: goodnesswins

75 nmol/l is 30 ng/ml


30 posted on 01/21/2022 8:56:43 AM PST by TTFX ( )
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To: SeekAndFind

Thanks.
Bkmk


31 posted on 01/21/2022 10:10:58 AM PST by Faith65 (Isaiah 40:31 )
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bkmk


32 posted on 01/21/2022 10:17:13 AM PST by mad_as_he$$
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To: SeekAndFind

Bookmark for my doctor appointment next week.


33 posted on 01/21/2022 10:18:58 AM PST by airborne (Thank you Rush for helping me find FreeRepublic! )
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To: Uncle Miltie

*


34 posted on 01/21/2022 12:54:39 PM PST by Taffini ( Mr. Pippen and Mr. Waffles do not approve and neither do I)
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To: metmom

“The blood of tens of thousands are on their hands.”

Millions.

Highly recommend the interview of Dr Peter McCullough MD by Dr Julie Ponesse on Rumble. Especially the end.


35 posted on 01/21/2022 6:33:21 PM PST by SecAmndmt (Cv19 vaccines are Phase 2 of the CCP bioweapon)
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To: SecAmndmt

I’ll look into that. Thank you.


36 posted on 01/21/2022 7:51:12 PM PST by metmom (...fixing our eyes on Jesus, the Author and Perfecter of our faith….)
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To: SecAmndmt; metmom

Here’s the link, to the interview video link you mentioned....

https://rumble.com/vt10hy-the-double-edged-fear-of-covid-19-dr.-peter-mccullough.html

Great interview....Dr Julie Ponesse’s statement, at the end, about Canadians, with their children, was a shocking eye opener.


37 posted on 01/21/2022 8:32:57 PM PST by Jane Long (What we were told was a “conspiracy theory” in 2020 is now fact. 🙏🏻 Ps 33:12 )
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To: Jane Long

BFLR


38 posted on 01/21/2022 10:41:57 PM PST by metmom (...fixing our eyes on Jesus, the Author and Perfecter of our faith….)
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To: SeekAndFind

Wow. Thanks for posting this.

Correct me if I am wrong, but isn’t this protocol very similar if not the same as original Zev Zelenko protocols?

Protocols that Zelenko used in New York at the initial NY outbreak in early 2020 which he sent to Trump in early Spring 2020—March if I recall.

How many debates have we had here on FR about the benefits of these supplements used in these combinations—and the doctors promoting them were called quacks and smeared?

Sad, but perhaps we can reopen some of those old threads and correct the record...if that’s not possible perhaps going forward, some minds around here can be opened.


39 posted on 01/22/2022 9:35:38 AM PST by Freedom56v2 (It's not the job of the unvaxxed to protect the vaxxed. That's the job of the "vaccine.")
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To: \/\/ayne

was at the pharmacy the other day and the pharmacist said “Any questions?” On my antibiotic prescription.

\/\/ayne: “If I had a prescription for Ivermectin, would you fill it?”

Pharmacist: “If we could get it I would. They are blocking it from us.”

The pharmacist then turned away quickly to attend to something.


This confirms what I heard Dr. Talia (MI physician) say on a RAV Whistleblower special...That large pharmacies are only getting ONE BOX PER MONTH WITH 20 TABLETS...gov’t is limiting—not sure if state or Feds...Tho some compounding pharmacies are getting around this.

Good news...This week. Bills are being considered in New Hampshire and Indiana that would allow pharmacists to dispense the Ivermectin by means of standing orders.


40 posted on 01/22/2022 11:22:07 AM PST by Freedom56v2 (It's not the job of the unvaxxed to protect the vaxxed. That's the job of the "vaccine.")
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