Posted on 01/06/2022 6:55:50 AM PST by SeekAndFind
Objective: The objective of this study was to evaluate the impact of regular ivermectin use on subsequent COVID-19 infection and mortality rates.
Materials and methods: We analyzed data from a prospective, observational study of the citywide COVID-19 prevention with ivermectin program which occurred between July 2020 to December of 2020 in Itajaí, Brazil. Study design, institutional review board approval, and analysis of registry data occurred after completion of the program. The program consisted of inviting the entire population of Itajaí to a medical visit in order to enroll in the program and to compile baseline, personal, demographic and medical information. In the absence of contraindications, ivermectin was offered as an optional treatment to be taken 2 consecutive days every 15 days at a dose of 0.2mg/kg/day.
In cases where a participating citizen of Itajai became ill with COVID-19, they were recommended to not use ivermectin or any other medication in early outpatient treatment. Clinical outcomes of infection, hospitalization, and death were automatically reported and entered into the registry in real time.
Study analysis consisted of comparing ivermectin users with non-users using cohorts of infected patients propensity score matched (PSM) by age, sex, and comorbidities. COVID-19 infection and mortality rates were analyzed with and without use of propensity score matching. Results: A total of 220,517 subjects were included in the analysis; 133,051 (60.3%) regular ivermectin users and 87,466 (39.7%) non-users. Using PSM, two cohorts of 3,034 subjects suffering COVID-19 infection were compared.
Observation: The regular use of ivermectin led to a 68% reduction in COVID-19 mortality [25 (0.8%) versus 79 (2.6%) among ivermectin non-users; risk ratio (RR), 0.32; 95% confidence interval (CI), 0.20 – 0.49; p < 0.0001]. When adjusted for residual variables, reduction in mortality rate was 70% (RR, 0.30; 95%CI 0.19 – 0.46; p < 0.0001). There was a 56% reduction in hospitalization rate (44 versus 99 hospitalizations among ivermectin users and non-users, respectively; RR, 0.44; 95%CI, 0.31 – 0.63; p < 0.0001). After adjustment for residual variables, reduction in hospitalization rate was 67% (RR, 0.33; 95%CI 023 – 0.66; p < 0.0001).
Conclusion: In this large, propensity score matched study, regular use of ivermectin as a prophylactic agent was associated with significantly reduced COVID-19 infection, hospitalization, and mortality rates. (We have uploaded the updated version of our manuscript after review by experts. Changes in the manuscript followed suggestions from experts.)
BTW, On the heels of this Brazilian study’s release, Twitter slapped a warning label on its distribution, calling it “Misleading” and preventing the document from being “replied to, shared or liked.”
Goes without saying.
And your point is ... ?????
A. Unless specifically prohibited by law, physicians are given leeway to prescribe medication for non-FDA-approved Off-Label use as their experience and conscience guides them.
B. Viagra was invented for treatment of high blood pressure and angina. When clinical trials showed it had little effect on angina but had a pronounced tendency to give all the men who took it boners, the FDA approved it for treatment of erectile dysfunction.
The clinical evidence clearly shows the efficacy of Ivermectin in preventing Covid infection and, once caught, reducing severity of symptoms. If Ivermectin were not being used as a political football, it would have FDA approval for fighting Covid.
And there are doctors who refuse to play the demoncrats silly-assed little game and are prescribing Ivermectin for preventing and treating Covid.
You tell yourself whatever lets you sleep at night but I'm not going to let something like the demoncrat's deliberate medical obstructionism stand in the way of the health and safety of me and my family.
The regimen for IVM as an antiparasitical is 0.15 mg/kg every 3 to 12 *months*. It’s not always possible to predict dose on the basis of half life of a drug.
No, not at all.
Bkmk
That’s libel. If I were the author of that study, I would sue the crap out of Twitter.
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