Ivermectin induces apoptosis of esophageal squamous cell carcinoma via mitochondrial pathway: Laboratory evidence that Ivermectin actually inhibits Esophageal Cancer!

BMC Cancer Biomedical Central ^ | 12/07/2021 | Nana Xu, Mengmeng Lu, Jiaxin Wang, et. al.

[SeekAndFind]

Abstract

Background

Esophageal squamous cell carcinoma (ESCC) is the most predominant primary malignant tumor among worldwide, especially in China. To date, the successful treatment remains a mainly clinical challenge, it is imperative to develop successful therapeutic agents.

Methods

The anti-proliferative effect of ivermectin on ESCC is investigated in cell model and in nude mice model. Cell apoptosis was assessed using flow cytometry, TUNEL assay and western blotting. Mitochondrial dysfunction was determined by reactive oxygen species accumulation, mitochondrial membrane potential and ATP levels.

Results

Our results determined that ivermectin significantly inhibited the proliferation of ESCC cells in vitro and in vivo. Furthermore, we found that ivermectin markedly mediated mitochondrial dysfunction and induced apoptosis of ESCC cells, which indicated the anti-proliferative effect of ivermectin on ESCC cells was implicated in mitochondrial apoptotic pathway. Mechanistically, ivermectin significantly triggered ROS accumulation and inhibited the activation of NF-κB signaling pathway and increased the ratio of Bax/Bcl-2.

Conclusions

These finding indicated that ivermectin has significant anti-tumour potential for ESSC and may be a potential therapeutic candidate against ESCC.

PEER REVIEW REPORTS

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RESEARCH CENTER COLLABORATION

1. Laboratory of Cancer Biomarkers and Liquid Biopsy, School of Pharmacy, Huaihe Hospital, Henan University, Kaifeng, 475004, Henan, China

2. Department of Radiation Oncology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan, China

3. Department of Cardiology, Huaihe Hospital, Henan University, Kaifeng, 475000, Henan, China

4. Department of Medical Oncology, Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, 19107, USA

5. Laboratory of Cancer Biomarkers and Liquid Biopsy, School of Pharmacy, Huaihe Hospital, Henan University, Kaifeng, 475004, Henan, China

[grobdriver]

now we'll see if I actually get it

You will. It just may take longer than you expect.

Mine from the same source was about a month.

[Chauncey Gardiner]

This is why ivermectin is a major threat to the Big Pharma money machine

[Maris Crane]

THAT is funny!

[unread]

"difficult between his indian accent and my increasingly poor hearing, but we got it done...now we'll see if I actually get it."

Please keep us informed... We've wanted to get some but have been very distrusting of the deal...

[ballplayer]

If these therapeutics were approved and repurposed for Covid,it would have made Vaccines for Covid illegal,that’s all you need to know

[Joshua]

I got mine from Indiamart but it took nearly 3 weeks