Ivermectin induces apoptosis of esophageal squamous cell carcinoma via mitochondrial pathway: Laboratory evidence that Ivermectin actually inhibits Esophageal Cancer!

BMC Cancer Biomedical Central ^ | 12/07/2021 | Nana Xu, Mengmeng Lu, Jiaxin Wang, et. al.

[SeekAndFind]

Abstract

Background

Esophageal squamous cell carcinoma (ESCC) is the most predominant primary malignant tumor among worldwide, especially in China. To date, the successful treatment remains a mainly clinical challenge, it is imperative to develop successful therapeutic agents.

Methods

The anti-proliferative effect of ivermectin on ESCC is investigated in cell model and in nude mice model. Cell apoptosis was assessed using flow cytometry, TUNEL assay and western blotting. Mitochondrial dysfunction was determined by reactive oxygen species accumulation, mitochondrial membrane potential and ATP levels.

Results

Our results determined that ivermectin significantly inhibited the proliferation of ESCC cells in vitro and in vivo. Furthermore, we found that ivermectin markedly mediated mitochondrial dysfunction and induced apoptosis of ESCC cells, which indicated the anti-proliferative effect of ivermectin on ESCC cells was implicated in mitochondrial apoptotic pathway. Mechanistically, ivermectin significantly triggered ROS accumulation and inhibited the activation of NF-κB signaling pathway and increased the ratio of Bax/Bcl-2.

Conclusions

These finding indicated that ivermectin has significant anti-tumour potential for ESSC and may be a potential therapeutic candidate against ESCC.

PEER REVIEW REPORTS

CLICK THIS LINK FOR DETAILS OF THE STUDY

RESEARCH CENTER COLLABORATION

1. Laboratory of Cancer Biomarkers and Liquid Biopsy, School of Pharmacy, Huaihe Hospital, Henan University, Kaifeng, 475004, Henan, China

2. Department of Radiation Oncology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan, China

3. Department of Cardiology, Huaihe Hospital, Henan University, Kaifeng, 475000, Henan, China

4. Department of Medical Oncology, Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA, 19107, USA

5. Laboratory of Cancer Biomarkers and Liquid Biopsy, School of Pharmacy, Huaihe Hospital, Henan University, Kaifeng, 475004, Henan, China

[servantoftheservant]

but but it’s only for horses! Da EFF DEE AAY told me!

[Vendome]

I heard it resolves halitosis and foot fungus...

[lee martell]

I’m going to be busy for X amount of minutes discecting, examining and defining each word or term in that headline.

[struggle]

SHHHHHHHH

[CJ Wolf]

That and it cures but itch.

[garandgal]

I was suspicious of this awhile ago, and started reading research papers. Ivermectin and Hydroxychloriquine are both useful cancer treatments. There are many studies...including for pancreatic cancer.

So now you know. This is why it could not be made widely available. Cancer patients might notice that their cancer had disappeared and people might start asking questions.

[BobL]

I thought Ivermectin only works for horses.

[nickcarraway]

It’s a worm dehorser.

[Stentor]

I thought Ivermectin only works for horses.

That's what the horses want you to think.

[Bob434]

lol

[sauropod]

.

[cherry]

I just today ordered oral tablet ivermectin thur india mart....I'm sure between my husband and myself we've hung up on these guys several times since we thought they were telemarketers...lol...

a little difficult between his indian accent and my increasingly poor hearing, but we got it done...now we'll see if I actually get it....

[spokeshave]

but we got it done...now we'll see if I actually get it....

It will come...maybe held up in Mumbai customs for a while...but otherwise no problemo.

[BobL]

“That’s what the horses want you to think.”

Can’t say I blame them. If I was a horse who had access to a dewormer that worked as well as Ivermectin does, I’d also do everything possible to keep Trump Voters from getting their hands on it too.

[Mr Radical]

I thought Ivermectin only works for horses
and Houyhnhnms.

[Pollard]

People are supposedly curing their cancer with another dewormer active ingredient fenbendazole

[Cobra64]

Horse… That’s because that’s what you’ve been told. Too many people are too lazy to look into the historical developmentlopment of the drug and it’s success in treating Covid patients.

[amihow]

This is why it could not be made widely available. Cancer patients might notice that their cancer had disappeared and people might start asking questions.
...........
I know of a physician who prescribed Ivermectin from beginning of Pandemic and said people who take it feel bettter generally.

[cranked]

That dern horse paste, sheesh......../s