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Scientists identify malfunctioning brain cells as potential target for Alzheimer's treatment (Senolytic drug/flavonoid (quercetin?) combo wipes them out)
Medical Xpress / by Wake Forest University Baptist Medical Center / Nature Aging ^ | Dec. 10, 2021 | Dehkordi, S.K. et al

Posted on 12/10/2021 1:06:08 PM PST by ConservativeMind

For the first time, scientists have identified a rare population of potentially toxic senescent cells in human brains that can serve as a target for a new Alzheimer's disease treatment.

Senescent cells are old, sick cells that cannot properly repair themselves and don't die off when they should. Instead they function abnormally and release substances that kill surrounding healthy cells and cause inflammation. Over time, they continue to build up in tissues throughout the body contributing to the aging process, neurocognitive decline and cancer.

Research conducted by Orr in 2018 found that senescent cells accumulated in mouse models of Alzheimer's disease where they contributed to brain cell loss, inflammation and memory impairment. When the researchers used a therapy to clear the senescent cells, they halted disease progression and cell death.

In total, they profiled tens of thousands of cells from the postmortem brains of people who had died with Alzheimer's disease.

The team found that approximately 2% of the brain cells were senescent and also identified the type of cell and the characteristic features.

The study findings indicated that the senescent cells were neurons, which are the fundamental units in the brain that process information and are the workhorses of memory. They also are the primary cells that are lost in Alzheimer's disease.

Orr is in the process of launching a clinical trial to test the effects of clearing senescent cells in older adults with mild cognitive impairment. The intervention, which was discovered by Orr's collaborators at the Mayo Clinic, consists of administering a repurposed U.S. Food and Drug Administration-approved drug designed to clear cancer cells in combination with a flavonoid, a plant-derived antioxidant.

The therapy worked well in Alzheimer's disease mouse models, and has proven safe in humans with other conditions, as previously reported by the Mayo Clinic.

(Excerpt) Read more at medicalxpress.com ...


TOPICS: Health/Medicine
KEYWORDS: alzheimers; alzheimerstreatment; treatment
The repurposed combo is very likely Dasatinib and Quercetin, which has been in other studies I’ve posted here.

Quercetin and fisetin are both senolytic flavonoids and are available in health food stores.

1 posted on 12/10/2021 1:06:08 PM PST by ConservativeMind
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To: Pete from Shawnee Mission; Mazey; ckilmer; goodnesswins; Jacquerie; Jane Long; BusterDog; jy8z; ...

The “Take Charge Of Your Health” Ping List

This list is for health articles and studies which describe something you or your doctor, when informed, may be able to implement for your benefit.

Please email me if you want on or off of this list.

2 posted on 12/10/2021 1:06:30 PM PST by ConservativeMind (Trump: Befuddling Democrats, Republicans, and the Media for the benefit of the US and all mankind.)
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To: ConservativeMind

Here comes the FDA! Supplements cure a debilitating ailment?! Off the shelves with them! Ramp up the usual media propagandists to discredit this study!

Friendly Dr Pharma has the $10,000.00 treatment(containing quercetin and flavonoids shhh), that you must get via prescription.


3 posted on 12/10/2021 1:16:17 PM PST by CTyank
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To: ConservativeMind

How much quercetin to fix or wipe out Joe Biden?


4 posted on 12/10/2021 2:10:15 PM PST by DannyTN
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To: ConservativeMind

Bkmk


5 posted on 12/10/2021 3:15:40 PM PST by ptsal (Vote R.E.D. >>>Remove Every Democrat ***)
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To: DannyTN

The universe does not contain enough quercetin to fix Brandon’s brain.


6 posted on 12/10/2021 3:36:08 PM PST by iceskater (I'm in the control group. ;))
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To: ConservativeMind

Once again, lousy research.

“Senescent cells are old, sick cells that cannot properly repair themselves and don’t die off when they should. Instead they function abnormally and release substances that kill surrounding healthy cells and cause inflammation.”

Who believes this tripe? This is evidence of poor blood circulation, failure to remove cellular waste from the brain and describes the biological reaction which results.


7 posted on 12/10/2021 7:50:54 PM PST by logi_cal869 (-cynicus the "concern troll" a/o 10/03/2018 /!i!! &@$%&*(@ -)
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