Posted on 11/30/2021 1:22:51 PM PST by ConservativeMind
Eliminating old, dysfunctional cells in human fat also alleviates signs of diabetes. The discovery could lead to new treatments for Type 2 diabetes and other metabolic diseases.
The cells in your body are constantly renewing themselves, with older cells aging and dying as new ones are being born. But sometimes that process goes awry. Occasionally damaged cells linger. Called senescent cells, they hang around, acting as a bad influence on other cells nearby. Their bad influence changes how the neighboring cells handle sugars or proteins and so causes metabolic problems.
Type 2 diabetes is the most common metabolic disease in the US. About 34 million people, or one out of every 10 inhabitants of the US, suffers from it. Most people with diabetes have insulin resistance, which is associated with obesity, lack of exercise and poor diet. But it also has a lot to do with senescent cells in people's body fat. And clearing away those senescent cells seems to stop diabetic behavior in obese mice. Alleviating the negative effects of fat on metabolism was a dramatic result, the researchers said. If a therapy worked that well in humans, it would be a game-changing treatment for diabetes.
Xu and his colleagues tested the efficacy of a combination of experimental drugs, dasatinib and quercetin. Dasatinib and quercetin had already been shown to extend lifespan and good health in aged mice. In this study, they found these drugs can kill senescent cells from cultures of human fat tissue. The tissue was donated by individuals with obesity who were known to have metabolic troubles. Without treatment, the human fat tissues induced metabolic problems in immune-deficient mice. After treatment with dasatinib and quercetin, the harmful effects of the fat tissue were almost eliminated.
"These drugs can make human fat healthy," says Xu.
(Excerpt) Read more at medicalxpress.com ...
I hate it when my old bad cells influence my good new ones.
Interesting. Ping for later consumption.
Or you could engage in regular extended fasts. Fasting is free!
most diabetics can’t fast. that is the problem.
fasting causes unsafe drops in insulin levels.
Ah the company you keep influences you!
And well known your cells are the average of their 6 closest friends…
Ah, good ol diabetes. It seems that diabetes is the springboard for every other disease under the sun. Eventually we all die of diabetes or its derivatives.
I’ve been taking quercetin since we first starting hearing that it was good against covid, about a year and a half. Over the next few months I lost more than 20 lbs. without trying...just figured I was eating less high calorie foods and smaller portions without realizing it. (That’s what I told myself). Anyone else out there in FReeperland taking quercetin and losing their spare tire?
Yes me, but I’m doing a little more exercise, no more beer, fasting, and eating Mediterranean.
P4L
any dosage recommendations?
Diabetics can switch to a low carb diet, which very often reverses diabetes. Fasting in the form of time restricted eating is a pretty flexible tool as well. But anyone on insulin needs to be monitored so their insulin can be adjusted as they go - or so I’ve read. OTOH, depending on insulin when your problem is growing resistance to insulin seems like a poor long term strategy. Seems the question is how to coordinate a withdrawal from dependency on insulin injections.
I get Jarrow Formulas Quercetin, 500mg., one a day. I get my supplements from Swansonvitamins.com. Good prices, good service. I’ve gotten knock-offs from Amazon in the past, so be careful when you use them.
And yet, it is important to get senolytics that can survive digestion long enough to work. For example Liposomal Fisetin.
However, stabilizing quercetin reduces its senolytic effects considerably.
LOL Hi Jim! Nice to see you.
I’ve been taking it for about a year, doctor said it could help with my asthma. It did, dries the lungs. It did not help with my weight. But 6 months ago I started extremely low carb and intermittent fasting. Have lost 30 pounds, A1C dropped half a point and cholesterol dropped 30 points. I appreciate this info seems all connected.
I belong to a group of T2 diabetics, all who have or in the process of reversing their T2 through fasting and keto/low carb eating.
I am no longer pre-diabetic after 3 years of keto and fasting and 210lb weight loss.
Read up on Dr. Jason Fung. The whole point of his books is reversing T2 diabetes through fasting. There is no such thing as an “unsafe” drop in insulin. Either you make insulin or you don’t (T1) or you are insulin sensitive or you’re insensitive (T2). The only way to become sensitive again is to drop your insulin levels and keep them low for long periods of time by not eating crap that raises your blood sugar so that you have to take more and more insulin to bring it down, thus completing the vicious cycle of SAD (standard American diet.
It’s free and no repurposed chemo drugs are needed.
Here.
Somebody has to show the new kids the ropes!
How much quercetin do you take, ryderann?
I’ve recently started taking it with fisten in a proprietary blend, 650 mg/day. Probably too early yet for me to notice if I’ve lost weight. I’ll continue with it.
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