Posted on 11/19/2021 12:43:12 PM PST by Red Badger
NIH research highlights importance of data-driven approach to identify novel drug targets.
Existing and emerging cancer drugs could be repurposed as therapies to be tested in clinical trials for people at genetic risk of Alzheimer’s disease, according to a new study published in Science Advances. Research combining analysis of brain protein alterations in these individuals as well as laboratory experiments in animal models and cell cultures could help scientists identify existing drugs to test for their potential as Alzheimer’s interventions more quickly.
The findings represent efforts from researchers at the National Institute on Aging (NIA), part of the National Institutes of Health; and NIA-supported teams at the University of California, San Francisco; Rush University, Chicago; and the Icahn School of Medicine at Mount Sinai, New York City.
The scientists identified brain protein changes related to the APOE4 genetic risk variant in young postmortem study participants (average age at death was 39 years) and compared these changes with those in the autopsied brains of people with Alzheimer’s and those without (average age at death was 89 years).
The analyses included brain samples from the Baltimore Longitudinal Study of Aging, the Religious Orders Study, and other NIA-funded studies. The researchers then tested whether existing Food and Drug Administration-approved or experimental drugs for other diseases act upon some of these proteins.
Their findings show an experimental drug for liver cancer and Dasatinib, approved for chronic myeloid leukemia, act upon some of these Alzheimer’s disease related proteins, suggesting they could be potential Alzheimer’s therapies. The drugs also reduced neuroinflammation, amyloid secretion, and tau phosphorylation in cell culture experiments, underscoring their potential as candidates to be tested in Alzheimer’s clinical trials.
These findings add to evidence from another recent study showing the value of this kind of data-driven approach to drug repurposing research. Next steps could include testing these drugs in clinical trials. For those already FDA-approved or that have already been tested for safety in other trials, the timeline for testing could be decreased.
About This Research Madhav Thambisetty, M.D., Ph.D., chief, Clinical and Translational Neuroscience Section, NIA Laboratory of Behavioral Neuroscience Luigi Ferrucci, M.D., scientific director, NIA Eliezer Masliah, M.D., director, NIA Division of Neuroscience NIA leads NIH’s systematic planning, development, and implementation of research milestones to achieve the goal of effectively treating and preventing Alzheimer’s and related dementias. This research is related to Milestone 7.B, “Initiate research programs for translational bioinformatics and network pharmacology to support rational drug repositioning and combination therapy from discovery through clinical development” and Milestone 7.C, “Continue to develop resources, capabilities and partnerships to advance data-driven drug repositioning and combination therapy.”
Reference: “A brain proteomic signature of incipient Alzheimer’s disease in young APOE ε4 carriers identifies novel drug targets” by Jackson A. Roberts, Vijay R. Varma, Yang An, Sudhir Varma, Julián Candia, Giovanna Fantoni, Vinod Tiwari, Carlos Anerillas, Andrew Williamson, Atsushi Saito, Tina Loeffler, Irene Schilcher, Ruin Moaddel, Mohammed Khadeer, Jacqueline Lovett, Toshiko Tanaka, Olga Pletnikova, Juan C. Troncoso, David A. Bennett, Marilyn S. Albert, Kaiwen Yu, Mingming Niu, Vahram Haroutunian, Bin Zhang, Junmin Peng, Deborah L. Croteau, Susan M. Resnick, Myriam Gorospe, Vilhelm A. Bohr, Luigi Ferrucci and Madhav Thambisetty, 10 November 2021, Science Advances. DOI: 10.1126/sciadv.abi8178
The research in this paper was funded by the NIA Intramural Research Program (1ZIAAG000436-01) and NIH grants P30AG10161, R01AG15819, R01AG053987, U01AG046170, and RF1AG057440.
About the National Institute on Aging (NIA): NIA leads the U.S. federal government effort to conduct and support research on aging and the health and well-being of older people.
About the National Institutes of Health (NIH): NIH, the nation’s medical research agency, includes 27 Institutes and Centers and is a component of the U.S. Department of Health and Human Services. NIH is the primary federal agency conducting and supporting basic, clinical, and translational medical research, and is investigating the causes, treatments, and cures for both common and rare diseases.
There is hope for Joe Biden yet!
OH NO!
We can't have that!
Drugs can’t be repurposed no matter how many lives could be improved or even saved.
Hey those drugs might have be used for horse dewormer.
DRA (Didn’t Read Article)
“Potential Alzheimer’s Treatments Discovered in Analysis of Existing Cancer Drugs”
NO WAY! Repurpose EXISTING drugs to treat a different disease?
THIS CAN NOT BE ALLOWED!!!!!
We MUST do EVERYTHING we can to prevent this TRAVESTY!
We MUST have peer reviewed studies over a period of YEARS to be sure they are SAFE for a disease they were never intended to treat.
I don’t care if they have been SAFE for DECADES treating cancer. Alzheimer’s is a DIFFERENT disease.
These people will just have to WAIT until the trials are all finished and THEN apply for FDA approval.
(We MUST prevent this drug’s repurposing at all costs. We have a NEW mRNA drug, developed at warp speed, ready for emergency use authorization (EUA), waiting in the wings, to treat Alzheimer’s. We will lose BILLIONS! if this existing drug is allowed to be repurposed)
All SARCASM! /s /s /s /s
I don’t trust anything out of Big Pharma these days.
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