Posted on 10/28/2021 8:24:09 PM PDT by SeekAndFind
The IC50 for the inhibition of viral replication were 0.3µM for M and 2.8µM for IV. Both drugs have good oral absorption, with M achieving peak plasma concentrations by 2 hours and IV by 5 hours.
The plasma half life were 7 hours for M and 81-91 hours for IV. M inhibits viral replication inducing viral mutagenesis in RdRp, causing viral error catastrophe and viral extinction.
IV affects viral cell entry, nuclear transport and inhibits replication via RdRp. IV has additional effect to suppress cytokine production through STAT-3 inhibition. M is a more potent antiviral drug and IV has a longer residence in the body.
Their effects on RdRp and cytokine inhibition are potentially complimentary for anti-COVID-19 activity.
Both IV and M should be compared in randomized controlled clinical trials, and the possibility of their combination for anti-SARS-CoV-2 antiviral actions, explored further.
(Excerpt) Read more at austinpublishinggroup.com ...
Putting a dog ear on this page for later
Ivermectin Source ( arrives in 3 weeks, USE PAY PAL, order 500 x 12mg tabs)
https://dir.indiamart.com/search.mp?ss=Ivermectin+12&prdsrc=1
Protocols to follow: ( for both prophylaxis and for treatment of infection):
Front Line Critical Care Alliance( Dr. Pierre Kory):
Is Indiamart a reliable source? I mean are they REAL Ivermectin and not some other fake placebo? How do we know?
The corporations involved in INdia make their drugs to FDC standards. They supply pharmacies in Europe, Canada and the United States.
How do you know that drugs you get from your pharmacey are not bogus? Most of them come from either India or China.
Its real simple. If a corporation in India sells inferior product, they lose their market share and would have to go out of business. These corporations are run by extended families in India, and so what they sell is competative , of superior quality, and a source of family pride.The standards of manufactire are enforced by the Government of India.
I use one company in particular, and have become fast friends with one of their agents.
The vast majority of drugs used today are manufactured abroad, and made according to FDA standards, or else your local pharmacy would not be selling them to you.
The Government of India enforces high standards of manufacture under the “Cosmetics Act.”
You can see a list of generic drug manufacturers in India here, along with their specialty in generic drug manufacture:
Indian Drug Manufacturers
https://www.medindia.net/drugs/manufacturers.asp
National Drug chains from around the world buy from them continuously. America has a declining pharmacy manufacturing
sector.....India’s is growing.India’s pharmacy sector is full of creative entrepreneurial geniuses, which is one of the reasons PDJT liked India so much.
Disclaimer: Opinions posted on Free Republic are those of the individual posters and do not necessarily represent the opinion of Free Republic or its management. All materials posted herein are protected by copyright law and the exemption for fair use of copyrighted works.