Posted on 10/26/2021 8:43:29 AM PDT by Red Badger
Novel obesity treatments such as modulation of the gut microbiome and gene therapy are underutilized and could help fight the obesity epidemic, according to a new manuscript published in the Endocrine Society’s journal, Endocrine Reviews.
Nearly half of the adults and 20 percent of children in the United States have obesity, yet doctors are under prescribing effective weight loss medications and many patients are not receiving the treatment they need. The weight stigma that exists in healthcare settings makes people with obesity hesitant to seek care until comorbidities develop and reach a dangerous stage. Lack of insurance coverage and cost issues are another factor that creates barriers to obesity treatment.
“Obesity is the epidemic crisis of our time. The disease leads to serious comorbidities such as diabetes, fatty liver disease and cardiovascular disease and significantly shortens a person’s length and quality of life,” said Christos S. Mantzoros, M.D., Sc.D., of Beth Israel Deaconess Medical Center in Boston, Mass. “Until recently we did not understand the genetic and hormonal causes of obesity and how obesity leads to these comorbidities. We have recently started to understand the causes of obesity in humans, which is a big discovery that has led to designing effective therapies.”
In the article, the researchers map out the molecular and hormonal pathways that lead to obesity and the disease’s related comorbidities. This data gives researchers the insights they need to design, test and implement new obesity therapies.
The researchers highlight the need for safer and more effective obesity therapies, including new drug delivery systems, vaccines, modulation of the gut microbiome and gene therapy. Novel medications, including combinations of gastrointestinal hormones and other molecules, are being tested and are expected to lead to significant percentages of weight loss with less side effects once available. As our understanding of obesity improves, more effective medications with fewer side effects will be developed.
Recently approved medications such as semaglutide, a modified gastrointestinal hormone administered once a week, can lead to 15% weight loss when combined with lifestyle changes. Bariatric surgery can lead to up to 40% weight loss, but it is invasive and linked to complications.
“Insurance companies need to pay attention to data from studies and the scientific progress we are making and start covering the medications that are and will be approved soon, given that currently only a small minority of patients with obesity have coverage for the medications and medical care they need,” Mantzoros said. “It would be much more cost effective to cover treatments early instead of waiting for comorbidities and their complications to develop.”
Other authors of the study include: Angeliki Angelidi and Matthew Belanger of Harvard Medical School in Boston, Mass., and Alexander Kokkinos and Chrysi Koliaki of Laiko General Hospital in Athens, Greece. The research received no external funding.
Reference: “Novel Non-invasive Approaches to the Treatment of Obesity: From Pharmacotherapy to Gene Therapy” 26 October 2021, Endocrine Reviews.
There are people that can 4000+ calories a day and NOT gain a pound. So genetics does play a role.
SHUT UP!!!!!!!
It’s coming! I guarantee it! They will not ban it outright, at first, just limit you to one beer a day......................
True.
This was recently posted on FR:
PROCESSED FOOD
According to the USDA, processed food is defined as any raw agricultural commodity that has been subject to washing, cleaning, milling, cutting, chopping, heating, pasteurizing, blanching, cooking, canning, freezing, drying, dehydrating, mixing, packaging or other procedures that alter the food from its natural state. This may include the addition of other ingredients to the food, such as preservatives, flavors, nutrients and other food additives or substances approved for use in food products, such as salt, sugars and fats.
So, by definition, most times we engage in food preparation and cook, we are in fact processing foods.
The American Academy of Nutrition and Dietetics says processed foods range on a scale of minimally processed to mostly processed:
Minimally processed foods — such as bagged spinach, cut vegetables and roasted nuts — are often simply pre-prepped for convenience.
Foods processed at their peak to lock in nutritional quality and freshness include canned tomatoes, frozen fruit and vegetables and canned tuna.
Foods with ingredients added for flavor and texture (sweeteners, spices, oils, colors and preservatives) include jarred pasta sauce, salad dressing, yogurt and cake mixes.
Ready-to-eat foods — such as crackers, chips and deli meat — are more heavily processed.
The most heavily processed foods often are frozen or pre-made meals, including frozen pizza and microwaveable dinners.
4 posted on 10/16/2021, 10:02:15 AM by ProtectOurFreedom (“Everything Woke turns to shit.” ~ President Donald Trump)
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I’m one of them. All the fat people in my extended family overeat and sit all day. I agree genetics is a large part of it, though.
Bread, Pasta, cakes, pies and sugary drinks are killing us.......................
Then why would you post the crap? Genetics is a huge factor in obesity.
To pump up declining grain prices.
“Being anti-fat...”
Through my years with the military and DOD, I have found that obesity is not an illness, it is result. And that result can be caused by numerous factors the person has no ability to recognize and/or correct.
I read your articles and I saw a whole lot of we are now finding out about relationships that genes and current theologies based upon outdated (faulty) recommendations are being formed. They don’t know for sure on anything about the causes of insulin resistance, heart disease, asthma, the effects of fiber, the overwhelming use of firing nickel ions through prepared foods, and many other related topics they are trying to convey some type of success for their studies.
And always remember, they are practicing medicine, not perfecting it.
wy69
Diet and exercise are “non-invasive”.
Nearly half of the adults and 20 percent of children in the United States have obesity, yet doctors are under prescribing effective weight loss medications ...
—
Perfect example of how screwed up the medical profession is. No mention of diet and exercise in the article. Instead of pushing more medication, doctors should work with patients to cut out the junk foods, pizza, and snacks from their diet.
I’ll say it another way:
Overeating is the number one cause.
Don’t feed them.
I smoke so I eat very little to make up for it. I love fasting. Once you can go 24-48 hours without eating, you can do amazing things with weight loss/control. It helps that I have no appetite. Long story due other medical issues that had long lasting effects (15 years now)
I keep my weight down. That extra health benefit allows me to smoke and drink more.
I know it shouldn’t be that way but I’m human. My wife can eat everything and stay as slim as she was at 20. She does work out. We have 2 very different approaches. Won’t matter she will out live me. She is 11 years younger.
If it’s not a vaccine, it’s not real medicine.
/s
“modified gastrointestinal hormone administered once a week”
Sounds like it fits the pharma never cure, but constantly sell model!
“Non-invasive treatment”=stop shoveling mounds of chow down your gullet.
“Genetics is a huge factor in obesity.”
Only for a few people. MOST fat people are eating too much sugar, too much refined wheat and sitting around too much.
But not for ectomorphs...
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