Posted on 10/26/2021 8:43:29 AM PDT by Red Badger
Novel obesity treatments such as modulation of the gut microbiome and gene therapy are underutilized and could help fight the obesity epidemic, according to a new manuscript published in the Endocrine Society’s journal, Endocrine Reviews.
Nearly half of the adults and 20 percent of children in the United States have obesity, yet doctors are under prescribing effective weight loss medications and many patients are not receiving the treatment they need. The weight stigma that exists in healthcare settings makes people with obesity hesitant to seek care until comorbidities develop and reach a dangerous stage. Lack of insurance coverage and cost issues are another factor that creates barriers to obesity treatment.
“Obesity is the epidemic crisis of our time. The disease leads to serious comorbidities such as diabetes, fatty liver disease and cardiovascular disease and significantly shortens a person’s length and quality of life,” said Christos S. Mantzoros, M.D., Sc.D., of Beth Israel Deaconess Medical Center in Boston, Mass. “Until recently we did not understand the genetic and hormonal causes of obesity and how obesity leads to these comorbidities. We have recently started to understand the causes of obesity in humans, which is a big discovery that has led to designing effective therapies.”
In the article, the researchers map out the molecular and hormonal pathways that lead to obesity and the disease’s related comorbidities. This data gives researchers the insights they need to design, test and implement new obesity therapies.
The researchers highlight the need for safer and more effective obesity therapies, including new drug delivery systems, vaccines, modulation of the gut microbiome and gene therapy. Novel medications, including combinations of gastrointestinal hormones and other molecules, are being tested and are expected to lead to significant percentages of weight loss with less side effects once available. As our understanding of obesity improves, more effective medications with fewer side effects will be developed.
Recently approved medications such as semaglutide, a modified gastrointestinal hormone administered once a week, can lead to 15% weight loss when combined with lifestyle changes. Bariatric surgery can lead to up to 40% weight loss, but it is invasive and linked to complications.
“Insurance companies need to pay attention to data from studies and the scientific progress we are making and start covering the medications that are and will be approved soon, given that currently only a small minority of patients with obesity have coverage for the medications and medical care they need,” Mantzoros said. “It would be much more cost effective to cover treatments early instead of waiting for comorbidities and their complications to develop.”
Other authors of the study include: Angeliki Angelidi and Matthew Belanger of Harvard Medical School in Boston, Mass., and Alexander Kokkinos and Chrysi Koliaki of Laiko General Hospital in Athens, Greece. The research received no external funding.
Reference: “Novel Non-invasive Approaches to the Treatment of Obesity: From Pharmacotherapy to Gene Therapy” 26 October 2021, Endocrine Reviews.
Nope! They’re wrong. Covid. Nothing but Covid.
More on Original Antigenic Sin and the Folly of Our Universal Vaccination Campaign
A deeper look at a decisive limitation of our adaptive immune systems.
https://eugyppius.substack.com/p/more-on-original-antigenic-sin-and
To review: We have now had ten months of mass vaccination against SARS-CoV-2. Nearly 7 billion doses have been administered worldwide. This unprecedented campaign has not eradicated Corona; it has not even suppressed infections. Instead, case statistics have ballooned almost everywhere. While the vaccinated appear to enjoy some protection against severe outcomes, skyrocketing transmission means most countries have seen little benefit, on balance, from their universal vaccination campaigns. The most pressing question has become, simply: What is going on?
Much more at the link above.
this won’t be a problem after the supermarket shelves are empty...
They need a cholesterol card! If it’s over 200 they’re not allowed to buy junk food or go to fast food joints!
AND NO BEER!.......................
I lost 20 lbs. after catching COVID, so...
https://graziadaily.co.uk/life/opinion/lesbians-likely-overweight/
I found it......................
Here’s an idea - drive a stake through the heart of the Crime Against Humanity known as the Food Pyramid and all of its high-carb/low-fat demon spawn.
Big Pharma and Big Carb will be suicidal.
Eat 6000 calories a day and blame your obesity on genetics.
The agriculture lobby is just as complicit. Cereals, grains, corn: they’re all animal feed. We’re producing massive amounts of it to “feed the planet,” but all we’re doing it making it fat. We need to focus on raising healthy animals again for consumption.
After forced medical vaccination for covid is established forced treatment for obesity will be next. Then forced treatment for being a conservative.
The Food Pyramid came from the agricultural lobby.
Eat 6000 calories a day and blame your obesity on Republicans.......................
Then forced treatment for being a Christian..........................
Government mandated diets and stomach stapling for everyone.
Or maybe the plan is to crash the economy and starve us thereby reducing obesity?
Understood. And it’s been the bane of our health since the mid-80s. Michelle’s take was not much better. It’s criminal that this is allowed to continue while the science and anecdotal evidence of diets like Keto, Paleo, South Beach, etc. are showing pretty conclusive results for our health.
And reducing the excess population...................
I went on the “Prism” diet in 1997. I lost 55 lbs and got down to 190. I’m 6’1”.
A major part of the diet was to learn about the nutritional value as well as harmful effects of foods. One thing I learned was this: Diet kills far more americans than smoking.
The result was, that though I always looked at the cigarette area in stores as the “poison” section, I learned to look at the candy and donut section the same way.
Disclaimer: Opinions posted on Free Republic are those of the individual posters and do not necessarily represent the opinion of Free Republic or its management. All materials posted herein are protected by copyright law and the exemption for fair use of copyrighted works.