Interesting
Posted on 09/29/2021 1:23:42 PM PDT by ConservativeMind
Worms don't wiggle when they have Alzheimer's disease. Yet something helped worms with the disease hold onto their wiggle in Professor Jessica Tanis's lab.
While all the worms were grown on a diet of E. coli, it turns out that one strain of E. coli had higher levels of vitamin B12 than the other.
"The worms we use all have exactly the same genetic background, they react to amyloid beta like humans do, and we can exactly control what they eat, so we can really get down to the molecular mechanisms at work."
In the brains of humans with Alzheimer's, the buildup of amyloid beta over the years causes toxic effects in cells, resulting in reduced energy, fragmentation of the mitochondria—the cells' power plants, and oxidative stress from an excess of free radicals. The same thing happens in C. elegans, Tanis said, but in a matter of hours. Amyloid beta causes paralysis in the worms.
"The read-out is black or white—the worms are either moving or they are not," Tanis said. "When we gave vitamin B12 to the worms that were vitamin B12 deficient, paralysis occurred much more slowly, which immediately told us that B12 was beneficial. The worms with B12 also had higher energy levels and lower oxidative stress in their cells."
The team determined that vitamin B12 relies on a specific enzyme called methionine synthase to work. Without the presence of that enzyme, B12 has no effect, Tanis said. Also, adding the vitamin to the diet only worked if the animals were deficient in B12. Giving more B12 to animals with healthy levels does not help them in any way. The team also showed that vitamin B12 had no effect on amyloid beta levels in the worms.
(Excerpt) Read more at medicalxpress.com ...
I guess that’s how I’d prefer it, if I can’t get rid of the plaques.
A recent study out of Finland suggests The regularly sitting in a sauna helps to prevent Alzheimer’s. Install a sauna!
A recent study out of Columbia suggest coffee helps prevent Alzheimers. Juan Valdez says drink coffee.
Interesting
My father got B12 shots from an old doctor who was in an independent practice. Dad lived to be 97.
I tried coconut oil on my dear, late step dad. He was too far gone in his dementia before I found out about it. It just made him more awake and agitated.
Bless his heart. He was a good man. Miss him dearly.
So if it don’t wiggle take B12?
And coffee is good for the liver, if one has consumed ample cocktails.
I give myself B12 injections weekly as part of my chronic pain management regimen. I also have shrinking gray matter. Maybe this will/has been helping.
May I ask the nature of your chronic pain?
“Worms don’t wiggle when they have Alzheimer’s disease”
So what do they do to verify that? Do an autopsy of the worms brain?
Mark
“Worms don’t wiggle when they have Alzheimer’s disease”
I do not wiggle NOW. Do I have Alzheimer’s? Should I take more B12? Should I start wiggling? I am so confused. Isn’t confusion a symptom of Alzheimer’s? I hate “Science”.
I have RSD/CRPS. Started in my left foot, has spread to my right foot, my stomach, my abdomen, my esophagus & throat. And I have degenerative disc disease. With RSD no surgeries except absolutely necessary. So my bad discs are just symptom treated. And I live in a very small circle. 1,000 steps a day.
“Worms don’t wiggle when they have Alzheimer’s disease”
This has nothing to do with Alzheimers. This is the early stages of the new studies for the replacement of viagra. Gotta keep them worms wiggling.
wy69
Between the worms and fruit flies... I think we’ll be okay.
Funny how the worm never remembers anything.
Any information on how this translates to optimal b12 daily dose in for people?
Ping
“Install a sauna!”
St. Greta of Thunberg disapproves.
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