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Antibodies from original strain COVID-19 infection don't bind to variants (Spike-only antibodies fail)
Medical XPress / University of Illinois at Urbana-Champaign / Nature Communications ^ | Sept. 20, 2021 | Liz Ahlberg Touchstone / Timothy J. C. Tan et al

Posted on 09/20/2021 2:05:44 PM PDT by ConservativeMind

People infected with the original strain of the virus that causes COVID-19 early in the pandemic produced a consistent antibody response, making two main groups of antibodies to bind to the spike protein on the virus's outer surface. However, those antibodies don't bind well to newer variants, a new study found.

"Antibody response is quite relevant to everything from understanding natural infection and how we recover from infection to vaccine design. The body has the capability to produce diverse antibody responses—it's estimated we could make a trillion different antibodies. So when you see people are making quite similar antibodies to a particular virus, we call it convergent antibody response," Wu said.

They focused on antibodies against the spike protein, the part of the virus that binds to receptors on human cells to infect them. The spike protein is the target of most vaccines.

They found that many antibody sequences converged into two main groups, indicating a consistent human immune response to the virus.

The researchers studied the convergent antibodies' ability to bind to several variants and found that they no longer bound to some. The finding has implications for the ability of new variants to reinfect people who contracted earlier versions of the virus, as well as for the continuing efficacy of vaccines and the design of possible vaccine boosters, Wu said.

"Even though this antibody response is very common with the original strain, it doesn't really interact with variants," Wu said. "That, of course, raises the concern of the virus evolving to escape the body's main antibody response. Some antibodies should still be effective—the body makes antibodies to many parts of the virus, not only the spike protein—but the particular groups of antibodies that we saw in this study will not be as effective."

(Excerpt) Read more at medicalxpress.com ...


TOPICS: Health/Medicine
KEYWORDS: antibodies; chinavirusvariants; collectivisthell; covid; covid19; mareksdisease; vaccine; variants; viruses
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To: packagingguy

The mRNA “vaccines” are based on computer modelling based on the virus. The original vaccine was dialed up in a few hours.

I’m guessing that these “booster” shots aren’t boosters in the old sense of the term (just using more of the same dead virus), but are really more like a software tweak in the model, which tweaks one’s DNA a bit differently to combat the new change in the virus.

I doubt anybody knows what effects continuous tweaking of one’s DNA will do.


41 posted on 09/20/2021 4:02:53 PM PDT by 21twelve (Ever Vigilant. Never Fearful.)
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To: bigbob

If you’d like to get your geek on...

https://www.cdc.gov/flu/about/viruses/types.htm


42 posted on 09/20/2021 4:11:55 PM PDT by mewzilla (Those aren't masks. They're muzzles. )
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To: Valpal1

Good point.


43 posted on 09/20/2021 4:21:04 PM PDT by Rokke
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To: ConservativeMind

Ivermectin doesn’t care what virus strain it is.


44 posted on 09/20/2021 4:21:32 PM PDT by jacknhoo ( Luke 12:51; Think ye, that I am come to give peace on earth? I tell you, no; but separation. )
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To: magna carta
my daughter caught COVID 2 times (never vaccinated) may be the reason why.

She lost 10 days of work and is already struggling financially, working in the restaurant business.


  1. If she had been vaccinated she'd probably would have gotten COVID-19 more times since the vaccinated seem more likely to catch the variants (See Israel and UK).
  2. With regards to her lost work and struggling financially and choice of careers, maybe she should consider a change of her career path?

45 posted on 09/20/2021 4:52:49 PM PDT by SoConPubbie (Mitt and Obama: They're the same poison, just a different potency)
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To: ConservativeMind
Nature does not stand still. Viruses are very adept at evolving due to their huge numbers. A variant resistant to a RNA jab becomes the next wave. Not only that but a variation that actually uses the Antibody as a Trojan Horse is very much a possibility because of the advantage it would give to the virus. It's called Antibody-dependent Enhancement (ADE) and it has happened with other viruses before.
46 posted on 09/20/2021 5:07:42 PM PDT by Nateman (If the Left is not screaming , you are doing it wrong.)
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To: Nateman

Virus finds a way.


47 posted on 09/20/2021 5:08:59 PM PDT by dfwgator (Endut! Hoch Hech!)
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To: ConservativeMind

Produced a d Directed by Fauci.


48 posted on 09/20/2021 5:21:06 PM PDT by maddog55 (The only thing systemic in America is the left's hatred of it!)
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To: ConservativeMind

Natural immunity is more than IgG immunity. There are T cells, IgM other cells. Natural immunity is 13x more effective than from vaccines.
Even if natural immunity is reduced with new variants, it’s even more pronounced for the mRNA injections


49 posted on 09/20/2021 5:22:50 PM PDT by grumpygresh (Civil disobedience by jury nullification. )
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To: Valpal1

You are right, a scientist on a Rumble video said the same. There is an animal reservoir. It was posted here that it’s in white tail deer, so make sure your venison is well cooked!


50 posted on 09/20/2021 6:25:57 PM PDT by packagingguy (Kit)
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To: SoConPubbie

yes I hope she figures out a better career path. She was the more difficult child.


51 posted on 09/20/2021 6:35:23 PM PDT by magna carta
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To: ConservativeMind

And once again ‘modern medicine’ concedes utter idiocy about natural immunity.


52 posted on 09/20/2021 7:26:39 PM PDT by logi_cal869 (-cynicus the "concern troll" a/o 10/03/2018 /!i!! &@$%&*(@ -)
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To: ConservativeMind

The point is the title is a lie.


53 posted on 09/20/2021 8:19:31 PM PDT by ifinnegan ( Democrats kill babies and harvest their organs to sell)
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To: ConservativeMind

I’m doomed. Only fealty to Fauci and repenting for my heresy of the great and mighty Fauci will save me. Jab me Fauci. Good and hard.


54 posted on 09/20/2021 8:50:48 PM PDT by Organic Panic (Democrats. Memories as short as Joe Biden's eyes.)
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To: ifinnegan

What I got from this.... Are new vaccines able to be made from people who were ‘vaccinated’ and got kung flu or is that for people who naturally recovered?


55 posted on 09/20/2021 8:54:09 PM PDT by Organic Panic (Democrats. Memories as short as Joe Biden's eyes.)
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To: ConservativeMind; ransomnote; eyeamok; packagingguy; All
The authors speak to only testing for antibodies to the spike protein, then they say people who actually got COVID-19 have a lot of antibodies to the rest of the virus length.

Here's a neat video from LabCorp that explains the various components of the Covid-19 (SARS-CoV-2) corona virus.

video explanation of corona virus and vaccine differences

https://www.brainshark.com/1/player/labcorp?dm=5&nrs=1&sfsess=%7B!$Api.Session_ID%7D&sfurl=%7B!$Api.Partner_Server_URL_350%7D&fb=0&r3f1=09334d1e121f4755054f2c4e440e0d1f19454a2b17090d0152&custom=semi-quantitative_testing

First, this is a very simplified but very good explanation of the actual SARS-CoV-2 virus particle, and its main components.

1: The nucleocapsid (RNA and N-protein) which is the heart of the virus, that actually overtakes the infected human cell and replicates itself continuously and advances the infection.

2: The shell of the virus, that supports the E-Protein, M-Protein, and others (unnamed, but irrelevant to this presentation)

3: The all important Spike Glycoprotein (S), The spike protein is the actual mechanism the virus uses to attach itself to the ACE2 receptor of a human cell and capture that cell to advance the infection.

Second, the video explains three different "Qualitative" antibody assays, specifically:

1: SARS-CoV-2 nucleocapsid antibody assay (164068) which detects high affinity antibodies to the nucleocapsid (RNA and N-protein) of the actual virus.

2: SARS-CoV-2 antibody IgG Spike assay (164055) which detects Mature IgG antibodies to the Spike protein of the actual virus.

3: SARS-CoV-2 antibody IgM Spike assay (164034) which detects Mature IgM antibodies to the Spike protein of the actual virus.

Third, the video presents the new SARS-CoV-2 Semi-Quantitative Total Antibody, Spike assay, (164090):

The description of this (164090) is a little sketchy in this video, but from other documentation it is clear that it is specifically focused on the modified Spike protein generated by the mRNA vaccines, and its best purpose is to measure the level of antibodies to the vaccine generated Spike protein

Fourth, note in that video that the focus is primarily on the 164090 Spike protein (vaccine generated) assay, and does not focus on "Qualitative" assays, the only assays for natural infection recovery generated antibodies.

There are actually some very important points made in the video discussion of the new "Quantitative" assay (164090).

1: This assay focuses on the Spike (S) protein generated by the mRNA vaccine, and NOT on the nucleocapsid (RNA and N-protein) which is the heart of the virus.

2: The meaning of the number produced by the assay is not yet fully characterized beyond indicating whether the person has antibodies and CANNOT at this time interpreted to indicate immunity.

3: So why was it launched? It is being used in many studies, and will be correlated with a number of different nutralization assays and parameters, making it more flexible in the long term for a post vaccination world.

4: It's available now to all LabCorp customers.

My personal note: I interpreted LabCorp's advertising of this ($10) test as showing whether you had been previously infected and recoverd from Covid-19, and got the test. It clearly does NOT show whether you had been previously infected and recoverd from Covid-19, and that is stated clearly in my test report. I then tried to order the correct qualitative test (164068) and they refused, stating 164068 could ONLY be orderd by doctors.

So what does that mean, and why is it important?

All previous expectations of the mRNA vaccines aside, this video clearly indicates that current measures of antibodies to this vaccine generated spike protein CANNOT be interpreted to provide immunity against Covid-19 infection.

And you just got that straight from the horse's mouth (LabCorp)

56 posted on 09/21/2021 1:17:11 AM PDT by Grandpa Drudge (Just an old man, desperate to preserve our great country for my great grandchildren.)
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