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Antibodies from original strain COVID-19 infection don't bind to variants (Spike-only antibodies fail)
Medical XPress / University of Illinois at Urbana-Champaign / Nature Communications ^ | Sept. 20, 2021 | Liz Ahlberg Touchstone / Timothy J. C. Tan et al

Posted on 09/20/2021 2:05:44 PM PDT by ConservativeMind

People infected with the original strain of the virus that causes COVID-19 early in the pandemic produced a consistent antibody response, making two main groups of antibodies to bind to the spike protein on the virus's outer surface. However, those antibodies don't bind well to newer variants, a new study found.

"Antibody response is quite relevant to everything from understanding natural infection and how we recover from infection to vaccine design. The body has the capability to produce diverse antibody responses—it's estimated we could make a trillion different antibodies. So when you see people are making quite similar antibodies to a particular virus, we call it convergent antibody response," Wu said.

They focused on antibodies against the spike protein, the part of the virus that binds to receptors on human cells to infect them. The spike protein is the target of most vaccines.

They found that many antibody sequences converged into two main groups, indicating a consistent human immune response to the virus.

The researchers studied the convergent antibodies' ability to bind to several variants and found that they no longer bound to some. The finding has implications for the ability of new variants to reinfect people who contracted earlier versions of the virus, as well as for the continuing efficacy of vaccines and the design of possible vaccine boosters, Wu said.

"Even though this antibody response is very common with the original strain, it doesn't really interact with variants," Wu said. "That, of course, raises the concern of the virus evolving to escape the body's main antibody response. Some antibodies should still be effective—the body makes antibodies to many parts of the virus, not only the spike protein—but the particular groups of antibodies that we saw in this study will not be as effective."

(Excerpt) Read more at medicalxpress.com ...


TOPICS: Health/Medicine
KEYWORDS: antibodies; chinavirusvariants; collectivisthell; covid; covid19; mareksdisease; vaccine; variants; viruses
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Vaccinated-only people don’t have antibodies to anything that is not the spike protein, so they will have fairly more issues with a newer infection than a COVID-19 survivor has.
1 posted on 09/20/2021 2:05:44 PM PDT by ConservativeMind
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To: ConservativeMind

So YoU NeEd To Be VaCcInAtEd EvEn If YoU HaD It BeCaUsE MaN MaDe SpIkE MaKeS BeTtEr AnTiBoDiEs.


2 posted on 09/20/2021 2:14:45 PM PDT by Skywise
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To: Skywise

Of course! Follow the science (FICTION)!


3 posted on 09/20/2021 2:16:29 PM PDT by A Formerly Proud Canadian (Ceterum autem censeo Justinius True-dope-us esse delendam)
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To: ConservativeMind

Isn’t this why they have new flu shots every year? Be causes viruses mutate.


4 posted on 09/20/2021 2:21:08 PM PDT by bigbob
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To: ConservativeMind

Read the last two paragraphs.

Implications and concerns.

Stuff we knew without this study.

Nothing at all saying any variant does escape immunity conferred by vaccine or being infected.


5 posted on 09/20/2021 2:24:11 PM PDT by ifinnegan ( Democrats kill babies and harvest their organs to sell)
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To: ConservativeMind

Then shouldn’t we stop vaccinating? If the virus just mutates to get around the vaccine this will never end, and each booster will be to variants that have come and gone.
Does anyone here have technical details about medicine who can shed some light here?


6 posted on 09/20/2021 2:25:32 PM PDT by packagingguy (Kit)
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To: bigbob

Is this why the same people keep getting colds?


7 posted on 09/20/2021 2:26:29 PM PDT by who_would_fardels_bear (This is not a tagline.)
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To: Skywise

We would all gladly chip in for a new keyboard for you.

That’s far worse than incorrectly used apostrophe’s.


8 posted on 09/20/2021 2:29:04 PM PDT by ProtectOurFreedom ("If I’m going to get my political views from those who chase balls, I’ll ask my dog.")
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To: who_would_fardels_bear

That’s a good guess (I would guess). Influenza, too.

Something like 20% of colds are caused by coronaviruses.


9 posted on 09/20/2021 2:30:59 PM PDT by ProtectOurFreedom ("If I’m going to get my political views from those who chase balls, I’ll ask my dog.")
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To: ConservativeMind

Now, all we need to do is follow the science! The science we are supposed to follow is treating us for a heart attack when what we have is a cold.

Way to go science!


10 posted on 09/20/2021 2:32:05 PM PDT by icclearly
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To: bigbob

2003 SARS COV1 patients were tested again in 2021 and still retained their immunity from infection 17 years prior.

Those SARS COV1 patients were tested with SARS COV2 (COVID) and they were immune because there was only 22% difference between SARS1 and SARS2.

Variants for Covid are less than 2% different from the original.

The CDC lied to us by telling us we needed flu shots every year. We’ve been their lab rats for a long time.

The webpage at the link has data collected comparing the health of non-vaccinated individuals (drastically better) with vaccinated people.

https://informedconsentdefense.org/

Up until around 1994, it seems vaccines were stable. But that year, the vaccinated began to become less heathy at an increasing rate year after year, with the vaccinated having severely more chronic health conditions and poor health compared with the unvaccinated.

In 1992, the CDC and FDA were weaponized (CDC started it’s 401c3 taking donations (publicly) from Bill Gates, George Soros, Pharma). The FDA changed it’s regulartory function to become co-conspirators with pharma, allowing FDA personelle to profit by using tax payer funds to develop drugs and then personally patenting them and retaining the proceeds. Gates weaponized the NIH, which also started it’s 501c3 in the early 90’s. Gates hired Fauci around 2000 to make drugs that Gates would force Africa to purchase because Gates controls the World Health Organization.

Some vaccines are good. They bank on us knowing that and blend them with damaging but profitable medications etc and then require all children to have them. The FDA staffer later admitted they destroyed evidence a particular vaccine contributed to autism. Our enemies own and control those agencies, which only pose as Federal agencies.

Instead of government resources using 501c3 funds to benefit the public, the NIH,CDC and FDA benefit Bill Gates and others and use our tax dollars to do it.


11 posted on 09/20/2021 2:33:10 PM PDT by ransomnote (IN GOD WE TRUST)
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To: ConservativeMind

Isn’t this kind of how it is with the common cold?


12 posted on 09/20/2021 2:33:45 PM PDT by BenLurkin (The above is not a statement of fact. It is either opinion, or satire. Or both.)
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To: packagingguy

my daughter caught COVID 2 times (never vaccinated) may be the reason why.
She lost 10 days of work and is already struggling financially, working in the restaurant business.


13 posted on 09/20/2021 2:42:32 PM PDT by magna carta
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To: ConservativeMind

National Geographic

SCIENCE

NOT EXACTLY ROCKET SCIENCE

BY ED YONG
PUBLISHED JULY 27, 2015

Leaky Vaccines Enhance Spread of Deadlier Chicken Viruses
Over the past fifty years, Marek’s disease—an illness of fowl—has become fouler. Marek’s is caused by a highly contagious virus, related to those that cause herpes in humans. It spreads through the dust of contaminated chicken coops, and caused both paralysis and cancer. In the 1970s, new vaccines brought the disease the under control.

Over the past fifty years, Marek’s disease—an illness of fowl—has become fouler. Marek’s is caused by a highly contagious virus, related to those that cause herpes in humans. It spreads through the dust of contaminated chicken coops, and caused both paralysis and cancer. In the 1970s, new vaccines brought the disease the under control. But Marek’s didn’t go gently into that good night. Within ten years, it started evolving into more virulent strains, which now trigger more severe cancers and afflict chickens at earlier ages.

Andrew Read from Pennsylvania State University thinks that the vaccines were responsible. The Marek’s vaccine is “imperfect” or “leaky.” That is, it protects chickens from developing disease, but doesn’t stop them from becoming infected or from spreading the virus. Inadvertently, this made it easier for the most virulent strains to survive. Such strains would normally kill their hosts so quickly that they’d die out. But in an immunised flock, they can persist because their lethal nature has been neutered. That’s not a problem for vaccinated individuals. But unvaccinated birds are now in serious trouble.

(…)

Link: https://api.nationalgeographic.com/distribution/public/amp/science/article/leaky-vaccines-enhance-spread-of-deadlier-chicken-viruses


14 posted on 09/20/2021 2:45:22 PM PDT by Fitzy_888 ("ownership society")
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To: ConservativeMind

Real World Studies and Data says this is PROPAGANDA and Both should be brought before the Medical Review Board. Your Natural immune system creates antibodies for the entire virus, not just the “spike” protein.


15 posted on 09/20/2021 2:45:48 PM PDT by eyeamok (founded in cynicism, wrapped in sarcasm)
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To: ransomnote

This is the second time on this forum someone has posted about the SARS COV1 and SARS COV2 immunity.

It looks like there is high cross-reactivity to the nucleocapsid of the two viruses. Perhaps this is the study you are talking about:

https://pubmed.ncbi.nlm.nih.gov/32623350/


16 posted on 09/20/2021 2:45:48 PM PDT by packagingguy (Kit)
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To: A Formerly Proud Canadian
Of course! Follow the science (FICTION)!

The biggest fiction of all, is that democrats follow the science.

Whenever they say they follow the science, they are making it up.

The only 'science' that democrats know is political science, and even then, they make it up as they go.
17 posted on 09/20/2021 2:46:52 PM PDT by adorno
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To: ifinnegan

The authors speak to only testing for antibodies to the spike protein, then they say people who actually got COVID-19 have a lot of antibodies to yhe rest of the virus length.

So, your point is?


18 posted on 09/20/2021 2:48:06 PM PDT by ConservativeMind (Trump: Befuddling Democrats, Republicans, and the Media for the benefit of the US and all mankind.)
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To: ConservativeMind

MAREK’S DISEASE IN CHICKENS EXPOSES TRUE DANGERS OF COVID INJECTIONS
https://www.bitchute.com/video/hL5uic3Y5Rpz/


19 posted on 09/20/2021 2:49:39 PM PDT by Fitzy_888 ("ownership society")
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To: All

Haven’t seen a % dominance number for Lambda or Mu lately.

We should be seeing that daily, given this study.


20 posted on 09/20/2021 2:49:58 PM PDT by Owen
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