COVID-19 vaccination for people with severe mental illness: why, what, and how? (perhaps the vaxx has terrible interactions with meds)

The Lancet ^ | February 3, 2021 | Victor Mazereel, MD Prof Kristof Van Assche, PhD Johan Detraux, MD Prof Marc De Hert, MD

[DoodleBob]

...What are the potential interactions between vaccines and psychotropic medications?

Not much is known about the effects of psychotropic medication on vaccination response. Antipsychotics might have a differential effect on several cytokines in people with psychosis, producing an anti-inflammatory effect in some individuals.76, 77, 78 An anti-inflammatory effect, however, might not always be desirable when considering vaccine efficacy because it might suppress the formation of antibodies. Clozapine use is associated with neutropenia, which can confer susceptibility to infection. A secondary antibody deficiency has been observed in patients with long-term clozapine use, putting these patients at risk of immunodeficiency.79 In a retrospective cohort study, clozapine was a possible risk factor for SARS-CoV-2 infection.80 Although a small study showed that influenza vaccination had no effect on clozapine serum concentrations,81 vaccination might affect clozapine concentrations through its action on cytochrome P450 metabolism.82 As of Dec 18, 2020, no pharmacodynamic data are available for the COVID-19 vaccines currently in testing to ascertain whether they influence cytochrome P450 metabolism and clozapine metabolism.

Lithium has been proposed as an immunomodulatory adjuvant to increase the efficacy of viral vaccines in humans83, 84 because it exhibits some pro-inflammatory properties.85 However, as lithium has also shown some anti-inflammatory properties in healthy participants & patients,86, 87 its effects remain unclear and could be dose dependent. Other mood-stabilising agents, such as valproic acid, carbamazepine, and lamotrigine, also show a differential effect on several cytokines in healthy participants.86

A meta-analysis showed that antidepressant treatment for people with major depression reduced the concentrations of several pro-inflammatory cytokines, resulting in an anti-inflammatory effect.88 Treatment with antidepressants normalised vaccination response to the varicella zoster vaccine in older patients (>60 years) w/major depression.70 ...Research is urgently needed to provide people with severe mental illness with adequate information on potential interactions between psychotropic medications and COVID-19 vaccines.

[DoodleBob]

In 2019, 11.1% of the population was taking an antidepressant, a 15% increase from 2015. Women’s use of antidepressants (15.1%) was more than twice that of men’s (7.0%). Women 45-64 years old had the highest prevalence of antidepressant use (21.6%).

In the week ending March 15, 2020, there was a 20% increase in filled prescriptions for attendant medications. Thus it is likely that more than 11% of the nation is on such medication.

....and yet, how psychotropic drugs affect vaccination response and efficacy remains to be seen.....such people were not in the trials supporting the EUAs.

Is it possible many of the fatalities we are seeing with "no know cause" are actually due to fatal (yet clinically untested) interactions with the messenger RNA platform of these shots, and the medications taken by this 11%+ of the country?

[BipolarBob]

Does the vaccine interfere with meth and fetanyl medications is all I want to know. Not a whole lot out there on these interactions. Oh yeah . . asking for a friend.

[DoodleBob]

Ping - for your consideration...you all track this sort of thing more diligently than me. Bob may have actual experience (he’s also very witty).

[Flick Lives]

Thus it is likely that more than 11% of the nation is on such medication.

....and yet, how psychotropic drugs affect vaccination response and efficacy remains to be seen.....such people were not in the trials supporting the EUAs.

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I guess we’ll find out with the ongoing clinical trial... involving 2/3’s of the U.S. population!

[DoodleBob]

I saw someone post, that their reply to any invasive vaccine query was “I’m in the control group.”

[DoodleBob]

Seriously, with a proper clinical trial, there are rigorous standards around data collection, questioning and timing of follow-ups, and so on. It would be extremely prudent for clinicians to know a) who's on psychiatric meds, b) dosages, c) if bad things happen, could the meds be causing the interaction.

Many FReepers and actual friends and family have gotten the shots. I don't question their sanity, call them sheeple blah blah blah. Getting a shot is a personal thing and I'm not in their shoes.

But if we're gonna unleash a shot under EUA with the proviso that we will do proper clincical trials for a few years (which is usually how long they run, vs this slap-dash 9-month alleged approval coming in Sept), let's do the trials correctly. Maybe the messenger RNA platform etc IS kosher. Or, maybe it's really nasty if you are on lithium...maybe people would like to know that.

Everyone knows you should not drink and take meds. If this anarchists' clinical trial isn't tracking this sort of thing on meds that 11%+ of the nation are taking, we won't know for certain know if it's safe.

Why, it's almost as if someone doesn't WANT to know if these shots are efficacious...

[Flick Lives]

I saw someone post, that their reply to any invasive vaccine query was “I’m in the control group.”

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I like that response.

[Chode]

so much for informed consent...