N-Acetylcysteine To Combat COVID-19: An Evidence Review

Therapeutics and Clinical Risk Management ^ | Nov 2020 | Zhongcheng Shi, Carlos A Puyo, et al.

[ConservativeMind]

N-acetylcysteine (NAC) has been used in clinical practice to treat critically ill septic patients, and more recently for COVID-19 patients. NAC has antioxidant, anti-inflammatory, and immune modulating Characteristics that may prove beneficial in the treatment and prevention of SARS-Cov-2. This review offers a thorough analysis of NAC and discusses its use in the treatment of COVID-19.

NAC, precursor of the antioxidant glutathione, has been used to loosen thick mucus in the lungs and treat acetaminophen overdose for decades. However, neck can also boost the immune system, suppress viral replication, and reduce inflammation. Despite these valuable features, neck has been mostly overlooked during the SARS-Cov and MERS-Cov epidemics, as well as the current COVID-19 epidemic.

NAC Offers the Following Key Features to Combat COVID-19

Antivirus Functions of NAC
[snip]

NAC Could Also be a Direct Inhibitor of SARS-Cov-2
[snip]

Immune-Modulating Properties of NAC
[snip]

NAC Can Reduce the Incidence of Pneumonia
[snip]

Improve Lung Function To Reduce Mortality Rate By Intravenous NAC
[snip]

Case Reports and Clinical Trials Using NAC To Treat COVD-19 Patients
[snip]

[ConservativeMind]

Ping of interest.

[Pollard]

I was planning on growing shiitake mushrooms again next Spring but I can’t find how much ergothioneine they have vs oyster. Most ergothioneine supplements seem to be made from both oyster and shiitake.

// King oyster, maitake, oyster, and shiitake contain the highest amounts of ergothioneine

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4056650/

All our little grocery stores have is white button or bella for fresh. Oyster and shiitake available in jars but are a product of china. Downside of living in the boonies.

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Looks like I need to feed cooked shiitake to our meat goats.

//Four whole raw shiitake mushrooms are a good source of riboflavin (13%) and copper (12%), but when you turn up the heat and consume them cooked copper goes up 72% and pantothenic acid and selenium go up to 52% and 33%, respectively.

https://www.mushroomcouncil.com/wp-content/uploads/2017/12/Versatility-in-Varieties.pdf

Goats need copper big time and also selenium.

[Pete from Shawnee Mission]

C.M. Great series of posts on this subject! Thanks!
(Have some, I suppose I need to stock up in case of D Dirtbin legislation!

[metmom]

Quercetin is also a mast cell stabilizer and can be used for allergies and conditions like Mast Cell Activation Disorder.

[ConservativeMind]

Glad to help!

[metmom]

Try Swanson Vitamins for supplements.

They sell good stuff and have regular sales.

[metmom]

BFLR

[2nd amendment mama]

Bookmark

[sauropod]

Bkmk

[missamyb]

Can anyone interpret the dosing recommendations? I don’t think I’m smart enough to figure it out. I tried but now I’m confused.

[ConservativeMind]

The diagram at the back basically shows you should take 1,200 mg spread out over 24 hours if you think you are infected.

You need to take quite a bit more if your COVID-19 shows your O2 is poor (using an oximeter) or you have pneumonia.

It says you could take 600 mg a day as a preventative, but it's not needed, so keep it until you think you are infected.

[missamyb]

Thank you! This is really helpful I have a bottle of this stuff I don’t remember why I got it but after reading this I’m sure happy I have it!

[Pollard]

Found some things, a study on shiitake/ergothioneine and a chart comparing ergothioneine content of various mushrooms

The present findings demonstrate that a diet containing shiitake mushrooms, as a source of ergothioneine, produces high levels of the anti-oxidant in blood.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4168387/#__sec16title

https://www.realmushrooms.com/ergothioneine-supplement-guide/

Highest is Oyster, then Lion's Mane & then Shiitake but all three are decent. Monday I'll be doing some shopping in Salem where our best selection for groceries is. Maybe I'll find some oyster/shiitake mushrooms.

I'll definitely be growing some mushrooms next Spring, oyster and shiitake. Oysters produce the first year but shiitake take a couple of years. I'm in humid Missouri now and have a deep, shady gully on the property and plenty of trees I need to cut down on the higher, flatter areas to convert it to pasture for the meat goats. Kunekune pasture pigs too as soon as I get a breeding pair. I've grown shiitake on logs once already and oyster will grow on logs as well. All the locals hunt for Sorrel mushrooms here which grow wild as do many inedible fungi.

Might try growing Lion's Mane too which can also grow on logs. The Lion's Mane are supposed to taste like lobster and I grew up eating lobster in MA. My dad was a lobsterman before my time and since he knew other lobstermen, he got a good deal on them.

[ConservativeMind]

Consider going to Asian food stores, especially Korean, for fresh shiitake and oyster.

[Pollard]

As Arnold of Happy Days would say; Bwaa haa haa haa.

I’m rural MO. Closest Asian food store would be St Louis, 200 mile round trip.

I’ll find out next week if they have oyster in the third closest town to us, 50mi round trip.(closest two are 40mi) I go there once every week or two. IIRC they have oyster at walmart but maybe not all the time.

Found today that there’s a mushroom farm another 20 miles South of there. Farm pickup orders will start again next Wed with pickup Fri. $12/lb fresh for most anything and they grow all three, oyster, shiitake and lion’s mane. Dried is $7/oz and supposed to be equiv to 7oz fresh. I have a dehydrator though. Maybe I’ll go to the farm once and grab 1lb each of all three as fresh and go from there.

[steve86]

Lion’s Mane does amazing things for me (extract). Presumably as a result of it supplying nerve growth factor.

[ConservativeMind]

Do it, and tell about it!

[Freedom56v2]

The authors have guidance as to the amount of NAC best to use per stage of COVID-19. Look at the graphic on the last page. I would suggest not taking NAC all the time as a preventative, as it can interfere with a few useful processes, but it definitely appears useful under any believed COVID-19 infection state.

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Good Points!

Thank you for pointing this out and posting!