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Coronavirus: Singapore study suggests Hydroxychloroquine and throat spray could protect against infection
South China Morning Post ^ | 04/26/2021

Posted on 08/02/2021 8:13:36 AM PDT by SeekAndFind

A team of clinician-scientists from Singapore’s National University Health System (NUHS) has found that oral hydroxychloroquine and povidone-iodine throat spray are effective in reducing the spread of Covid-19 in high-transmission settings such as dormitories, cruise ships and prisons.

Their findings, which were presented to the media on Friday, were based on a study of more than 3,000 migrant workers living in Tuas South Dormitory during the height of the Covid-19 outbreak in May last year. Hydroxychloroquine is a prescription drug used to treat malaria and arthritis while povidone-iodine throat sprays are over-the-counter medications that provide symptomatic relief of sore throat.

The findings indicate a ‘viable preventive strategy’ against the spread of Covid-19 in high-transmission settings such as dormitories, cruise ships and prisons At the height of the pandemic last year, some of Singapore’s largest clusters emerged among the city state’s migrant workers, housed in crowded dormitories

The study, the largest on Covid-19 preventive therapy involving these drugs, was published in the International Journal of Infectious Diseases on April 14.

Associate professor Raymond Seet, the study’s lead author, said only two methods besides vaccines have been effective in reducing the transmission of the coronavirus: wearing masks and social distancing. However, the study demonstrated the benefits of preventive therapy with either oral hydroxychloroquine and povidone-iodine throat spray in closed settings, both of which are easily available and safe for use.

(Excerpt) Read more at scmp.com ...


TOPICS: Health/Medicine; Science; Society
KEYWORDS: coronavirus; covid19; hcq; hydroxychloroquine; povidoneiodine; raymondseet; singapore; throatspray
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SOME DETAILS OF THE STUDY:

As part of the study, 3,037 migrant workers from Tuas South Dormitory aged between 21 and 60, with a mean age of 33, were recruited to participate in a randomised clinical trial.

The dormitory was chosen for the trial as it was still in the early stages of the Covid-19 outbreak, said Seet, a senior consultant at the National University Hospital (NUH). Participating workers had no previous diagnosis of Covid-19, did not exhibit symptoms of respiratory illness and had negative serological tests for the coronavirus at the start of the study. These workers, who shared their rooms with non-participants, were spread over 40 floors of the dormitory, with each floor making up a “cluster”

Their rooms, which housed eight to 12 workers each, were also graded according to the risk of Covid-19 exposure. Unexposed rooms, for instance, had no confirmed Covid-19 cases prior to the trial. Each cluster was then randomly assigned to consume one of five types of medication for a period of six weeks. They were:

Vitamin C (500mg daily)

A combination of Vitamin C (500mg daily) and zinc (80mg daily)

Povidone-iodine throat spray (270μg daily)

Hydroxychloroquine (400mg once followed by 200mg daily)

Ivermectin which is used to treat parasitic infections (12mg once)

Seet said the medications were chosen to target the oropharyngeal space, which is the key entry point for viruses.

As a widely used but unproven remedy during the pandemic, Vitamin C was picked as the medication against which the other drugs’ effectiveness would be compared.

By the end of six weeks, 1,681 participants, or a little more than half, were diagnosed with Covid-19.

The frequency of infection was also significantly lower in participants who used hydroxychloroquine or the throat spray, compared to Vitamin C.

The following were the infection rates for trialled medications:

Vitamin C: 70 per cent infected (or 433 out of 619 participants)

Hydroxychloroquine: 49 per cent infected (or 212 out of 432)

Throat spray: 46 per cent infected (or 338 out of 735)

Ivermectin: 64 per cent infected (398 out of 617)

Vitamin C and zinc: 47 per cent (or 300 out of 634)

Seet noted there was a “significant absolute risk reduction” of over 20 per cent for those who took hydroxychloroquine and throat spray.

Although the cluster which consumed a combination of Vitamin C and zinc also had more than 20 per cent in absolute risk reduction, there was not enough statistical evidence to prove that the difference is not just due to luck, said associate professor Alex Cook from the National University of Singapore’s Saw Swee Hock School of Public Health. He was one of the 15 authors of the study.

According to a press release issued by NUHS, the findings suggest povidone-iodine could create an environment within the oropharyngeal space relatively resistant to the coronavirus. A reduction in viral load could also reduce the exposure of virus particles to their close contacts during the incubation and asymptomatic phases of infection, interrupting transmission. When asked whether the findings show that the drugs could be used in another dormitory outbreak, Seet said the study was designed to address such situations anywhere around the world involving a closed, crowded, high-exposure setting.

1 posted on 08/02/2021 8:13:36 AM PDT by SeekAndFind
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To: SeekAndFind

If you take therapeutics, Democrats will be upset that you are not doing your duty to “decrease the surplus population”.


2 posted on 08/02/2021 8:18:46 AM PDT by alstewartfan (The dawn is turning away The ghost of Charlotte Corday. Al Stewart)
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To: SeekAndFind

I wonder if that Zircam nasal spray Rush used to promote would have been useful. It had zinc, for starters.


3 posted on 08/02/2021 8:18:49 AM PDT by Dr. Sivana (There is no salvation in politics.)
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To: alstewartfan

How can this be??? Trump talked about hydroxychloroquine. The media and liberals and Democrats jumped all over him that he was full of it, and that people would die if they use hydroxychloroquine.

Now we have a study which seems to agree with what Trump was talking about???? How can this be???? Trump allegedly was full of it.


4 posted on 08/02/2021 8:20:39 AM PDT by Dilbert San Diego
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To: Dr. Sivana

RE: I wonder if that Zircam nasal spray Rush used to promote would have been useful. It had zinc, for starters.

Speaking of Nasal Sprays, we had a whole thread on this posted last night. There’s one available now.

See here:

https://freerepublic.com/focus/f-chat/3981262/posts


5 posted on 08/02/2021 8:22:46 AM PDT by SeekAndFind
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To: Dr. Sivana

Xlear Nasal Spray, dentist are using it to help stop transmission of covid. Available OTC.

https://www.dentistryiq.com/personal-wellness/article/14195726/xylitol-a-major-player-in-covid19-prevention


6 posted on 08/02/2021 8:26:46 AM PDT by chuck allen
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To: SeekAndFind

Hey is someone trying to cut into the Pfizer and Moderna profit margins here.


7 posted on 08/02/2021 8:32:34 AM PDT by Nextrush (FREEDOM IS EVERYBODYS BUSINESS, REMEMBER PASTOR NIEMOLLER)
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To: Dr. Sivana

It does not have zinc. It used to have zinc. People were losing their sense of smell. It now has no zinc.


8 posted on 08/02/2021 8:34:03 AM PDT by RummyChick (To President Trump: https://freerepublic.com/focus/f-chat/3923111/posts)
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To: SeekAndFind

I have to go get dog food today. I get it at the feed store and will be grabbing some Ivey while I’m there.


9 posted on 08/02/2021 8:51:31 AM PDT by Pollard
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To: SeekAndFind

Again it doesn’t matter, its either take the vaccine, or they WILL ruin your life.


10 posted on 08/02/2021 9:01:20 AM PDT by TexasM1A
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To: SeekAndFind

The ‘vaccine’ doesn’t prevent the spread of the virus. So it ain’t even a vaccine, it is a treatment.

HCQ is a treatment.

Invermectin is a treatment.

They should just label HCQ and Invermectin as ‘vaccines’.


11 posted on 08/02/2021 9:09:53 AM PDT by Kevmo (Right now there are 600 political prisoners in Washington, DC.)
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To: SeekAndFind

I ordered Xlear nasal spray from Amazon last night; and I’ll be chewing xylitol gum daily.


12 posted on 08/02/2021 9:38:19 AM PDT by Flaming Conservative ((Pray without ceasing))
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To: SeekAndFind

Ivermectin, one dose covering the full six weeks, and it still reduced COVID infection?

That’s pretty amazing.


13 posted on 08/02/2021 10:10:47 AM PDT by ConservativeMind (Trump: Befuddling Democrats, Republicans, and the Media for the benefit of the US and all mankind.)
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To: SeekAndFind

They missed the boat AGAIN! They should have combined zinc with the Hydroxychloroquine instead of the vitamin C.

Useless study.

How about combining zinc with the Hydroxychloroquine and that nasal spray?

DUH!


14 posted on 08/02/2021 10:40:18 AM PDT by faucetman (Just the facts, ma'am, Just the facts )
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To: chuck allen

Here is another one about xlear nasal spray.

Be sure to scroll down to read the case studies.

ACTUAL, REAL, INFORMATION!


15 posted on 08/02/2021 11:16:57 AM PDT by faucetman (Just the facts, ma'am, Just the facts )
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To: Dr. Sivana

I use Povidone-Iodine mouthwash gargle 30 seconds + First Defense antiviral nasal spray + Cold Eze zinc lozenges at the first sign of a sore throat. Seems to be highly effective for me. Not one sore throat has progressed to a cold which is important for me because colds usually become bronchitis.


16 posted on 08/02/2021 11:23:23 AM PDT by ProtectOurFreedom (“Criminal democrats kill babies. Do you think anything else is a problem for them?” ~ joma89)
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To: alstewartfan

“Ivermectin 12mg once”

Once? Why just a single dose? Nothing lasts long in the body and certainly not IVM.


17 posted on 08/02/2021 11:25:09 AM PDT by ProtectOurFreedom (“Criminal democrats kill babies. Do you think anything else is a problem for them?” ~ joma89)
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To: SeekAndFind

That’s a bannin’!


18 posted on 08/02/2021 11:29:46 AM PDT by FrankRizzo890
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To: FrankRizzo890

19 posted on 08/02/2021 11:30:38 AM PDT by dfwgator (Endut! Hoch Hech!)
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To: ProtectOurFreedom

I said nothing about how often ivermectin should be taken. (?????)


20 posted on 08/02/2021 11:37:19 AM PDT by alstewartfan (The dawn is turning away The ghost of Charlotte Corday. Al Stewart)
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