Posted on 07/07/2021 6:32:10 PM PDT by ConservativeMind
Pain where the jaw hinges to the skull is both common and difficult to treat. Killing off aged cells might be the secret to healing it.
Age worsens joint deterioration in many parts of the body. Scientists aren't sure why, but in many cases this deterioration seems related to old, damaged cells that refuse to die. Normally, cells in our body are constantly renewing themselves. Most cells that get damaged or begin to turn cancerous are removed by our immune system to make way for fresh, young, healthy cells.
But sometimes these cells stick around. Called senescent cells, they are somehow resistant to the normal ways the body rids itself of damaged cells.
And senescent cells don't just accumulate. They seem to actively promote inflammation and damage to surrounding cells.
They combined Dasatinib, a senolytic that removes senescent cells from connective tissue like cartilage and bones, and Quercetin, which goes after senescent cells in blood vessels and skin. The combination is necessary because joints are complex structures made of many different types of tissue.
The researchers gave 24-month-old mice (equivalent to 70 to 80-year-old humans) a combination of Dasatinib and Quercetin three times every two weeks for six weeks. After the treatments, the cells in the jaw joints of the old mice looked more like the cells in the jaw joints of 4-month-old mice (equivalent to 15 to 20-year-old humans) than those of their fellow oldsters. The cartilage was thicker and the bone smoother, making the joints look like those of much younger animals. No other treatment known at this time can thicken cartilage in joints.
Another study recently published by Xu's team in NPJ Regenerative Medicine shows that treating aged stem cells in a petri dish with the Dasatinib-Quercetin combination rejuvenated them.
(Excerpt) Read more at medicalxpress.com ...
Quercetin is very very interesting.
Bttt
Have you tried Fisetin? Sound interesting and something good to take
I can't say I notice anything one way or another, but I trust it's helpful.
I’ve used quercetin for the last 10 years to control my allergies - works like a charm.
Yeah, interesting indeed to me. I have been taking Quercetin Plus (500 mg quercetin + 1,400 mg vitamin C not from citrus fruit) for about a year and a half now, to ward off infection by the COVID-19 virus. I get it from Vitamin Shoppe, 300 capsules per bottle for less than $50.
With this dosage I also daily ingest zinc 50mg (as zinc oxide and/or zinc gluconate), vitamin D3 2 gelcaps 2000 i. u. apiece, a 325 mg aspirin, a B12 tablet, a B Complex tablet, plus my prescribed blood pressure pills and a fish oil gelcap. Additionally, if anything even indicating a virus symptom seems on the horizon, I also take a 20 mg Pepcid pill (generically famotidine, $6 for a bottle of 100 tablets at Walmart) until the slight cough, sneeze or runny nose goes away, then I stop it.
We will see how this affects the small re-growth of the meningioma non-cancerous tumor that was surgically removed in September of 2010. I'll mention this article to my doctor. I underwent an MRI scan last Thursday, taken to better define the re-growth nodule detected by CAT scan back in February.
According to the medical literature, the Quercetin Plus dosage could be doubled without harm. We'll see. The quercetin is self-prescribed. Maybe I can get my doctor (who has at least not objected or even issued a caution about it) on board with a firm assent. If he prescribed it, my Medical Advantage Plan might actually pay for the quercetin.
I have been quite well from the virus standpoint all along, having refused to be vaxxed, with good reason. In this time frame I have put up siding and installed six windows, and a garage overhead door, going up and down ladders, raising a 20-foot ladder and a 24-foot ladder, all this by myself, since the pandemic hoorah started.
My 84th birthday was last November. Hmmm.
Sounds like you’re doing all the right things. Thanks for sharing....and, keep up the great work.
Very impressive!
Strawberries.
Lots of strawberries.
(Maybe Capt Queeg was on to something!)
It has low bioavailability. You must take a lot and often. Sorry to rain on the parade.
It was actually helping my mast cell reactions.
Until I started reacting to IT.
I was so ticked when I realized it. And I have tried it several times since then, and I still react to it.
One problem with Fisetin is that it is quickly broken down in the digestive tract. However, a new sublingual liposomal is now available for sale.
That is, you squirt it under your tongue and keep it in your mouth for a few minutes, and it rapidly increases your serum Fisetin level by penetrating directly to your bloodstream. And because it is liposomal “oil soluble” it enters your cells and liver, unlike “water soluble” substances that are quickly eliminated.
Manufacturer is ‘Alive By Science’.
Thank you, I’ll look it up.
The legendary Mrs. Whiskers won’t need it: she’s addicted to strawberries.
p
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