Posted on 06/17/2021 11:18:48 AM PDT by Red Badger
With the rollout of COVID-19 vaccines accelerating, people are increasingly asking which vaccine is best?
Even if we tried to answer this question, defining which vaccine is "best" is not simple.
Does that mean the vaccine better at protecting you from serious disease? The one that protects you from whichever variant is circulating near you? The one that needs fewer booster shots? The one for your age group? Or is it another measure entirely?
Even if we could define what's "best", it's not as if you get a choice of vaccine. Until a suite of vaccines become available, the vast majority of people around the world will be vaccinated with whichever vaccine is available.
That's based on available clinical data and health authorities' recommendations, or by what your doctor advises if you have an underlying medical condition. So the candid answer to which COVID vaccine is "best" is simply the one available to you right now.
Still not convinced? Here's why it's so difficult to compare COVID vaccines.
Clinical trial results only go so far You might think clinical trials might provide some answers about which vaccine is "best", particularly the large phase 3 trials used as the basis of approval by regulatory authorities around the world.
These trials, usually in tens of thousands of people, compare the number of COVID-19 cases in people who get the vaccine, versus those who get a placebo. This gives a measure of efficacy, or how well the vaccine works under the tightly controlled conditions of a clinical trial.
And we know the efficacy of different COVID vaccines differ. For instance, we learned from clinical trials that the Pfizer vaccine reported an efficacy of 95 percent in preventing symptoms, whereas AstraZeneca had an efficacy of 62-90 percent, depending on the dosing regime.
But direct comparison of phase 3 trials is complex as they take place at different locations and times. This means rates of infection in the community, public health measures and the mix of distinct viral variants can vary. Trial participants can also differ in age, ethnicity and potential underlying medical conditions.
We might compare vaccines head to head One way we can compare vaccine efficacy directly is to run head-to-head studies. These compare outcomes of people receiving one vaccine with those who receive another, in the same trial.
In these trials, how we measure efficacy, the study population and every other factor is the same. So we know any differences in outcomes must be down to differences between the vaccines.
For instance, a head-to-head trial is under way in the UK to compare the AstraZeneca and Valneva vaccines. The phase 3 trial is expected to be completed later this year.
Late to post, but very excited to be taking part in the Valneva phase 3 vaccine trial! As it's no longer ethical to give anyone placebo, the everyone gets either Valneva or AstraZeneca 🥰 #vaccinated #valneva #clinicaltrial pic.twitter.com/iyhZl8Vt4Y
— Lizzie Wadsworth (@LizzieWadz) May 27, 2021 How about out in the real world? Until we wait for the results of head-to-head studies, there's much we can learn from how vaccines work in the general community, outside clinical trials. Real-world data tells us about vaccine effectiveness (not efficacy).
And the effectiveness of COVID vaccines can be compared in countries that have rolled out different vaccines to the same populations.
For instance, the latest data from the UK show both Pfizer and AstraZeneca vaccines have similar effectiveness. They both reliably prevent COVID-19 symptoms, hospitalisation and death, even after a single dose.
So what at first glance looks "best" according to efficacy results from clinical trials doesn't always translate to the real world.
What about the future? The COVID vaccine you get today is not likely to be your last. As immunity naturally wanes after immunisation, periodic boosters will become necessary to maintain effective protection.
There is now promising data from Spain that mix-and-matching vaccines is safe and can trigger very potent immune responses. So this may be a viable strategy to maintain high vaccine effectiveness over time.
In other words, the "best" vaccine might in fact be a number of different vaccines.
Variant viruses have started to circulate, and while current vaccines show reduced protection against these variants, they still protect.
Companies, including Moderna, are rapidly updating their vaccines to be administered as variant-specific boosters to combat this.
So, while one vaccine might have a greater efficacy in a phase 3 trial, that vaccine might not necessarily be "best" at protecting against future variants of concern circulating near you.
The best vaccine is the one you can get now It is entirely rational to want the "best" vaccine available. But the best vaccine is the one available to you right now because it stops you from catching COVID-19, reduces transmission to vulnerable members of our community and substantially reduces your risk of severe disease.
All available vaccines do this job and do it well. From a collective perspective, these benefits are compounded. The more people get vaccinated, the more the community becomes immune (also known as herd immunity), further curtailing the spread of COVID-19.
The global pandemic is a highly dynamic situation, with emerging viral variants of concern, uncertain global vaccine supply, patchy governmental action and potential for explosive outbreaks in many regions.
So waiting for the perfect vaccine is an unattainable ambition. Every vaccine delivered is a small but significant step towards global normality. The Conversation
Wen Shi Lee, Postdoctoral researcher, The Peter Doherty Institute for Infection and Immunity and Hyon Xhi Tan, Postdoctoral researcher, The Peter Doherty Institute for Infection and Immunity.
This article is republished from The Conversation under a Creative Commons license. Read the original article.
https://theconversation.com/which-covid-vaccine-is-best-heres-why-thats-really-hard-to-answer-161185
Moms Mabley izzat you?..................
For kids, it seems the God given vaccine works the best. They should NOT be getting an additional shot.
All the Covid vaccines thus far are toxic in that they distribute spike proteins, or portions of spike proteins, throughout your body within the first 48 hours. That’s why so many people feel miserable. The distribution shifts to collect in organs - the particles trigger inflammation and are cytotoxins.
The mRNA and DNA versions (Moderna, AstraZeneca, J&J, Pfizer) use either DNA or mRNA to trigger production of these cytotoxins.
The new one, Novavax purifies the spike proteins from the moth cells used to grow them. This means Novavax is an injection of pure spike proteins.
This technique requires repeated booster shots, each time adding additional risks of strokes, heart attacks, miscarriage, paralysis etc. It’s so not worth the risk for a disease with a treatment recovery profile similar to the flu.
Safe, effective treatments are available. The ‘vax’ is not necessary and is harmful, and the long term effects are unknown.
Had both Pfizers. I now have my finger nails falling off. Saw my Gp, the transplant team and a dermatologist, and no one knows what it is. Just hoping they grow back.
Or, like me, take nothing but vitamins and zinc and have a stuffy nose for two days and a little muscle soreness for the same time and get eight days of paid “isolation” feeling fine and dandy.
And being naturally immune.
never heard of her...
thanks to you and the internet i learned something new today...
“efficacy of 95 percent”
horshiite
redo the math. Lots of threads about it.
She was a stand-up comedienne back in the day, and one of her jokes was:
There are so many people in China they have run out of names for them all!
So when a baby is born they just throw a bunch of silverware up in the air and whatever noise it makes when it comes down is what the name them!..........
Your post reminded me of that !..............
Judiciously applied, the western scientific method can tell us much. But real world conditions are so complex we really cannot interpret or extrapolate the absolute verity of the findings in such limited studies. Your spaghetti against the wall analogy kinda fits.
All the reason to be carefully analyzing/accepting of all the pronouncements of the “scientific elite”.
never heard of her until today...
wonder what sounds dropped chopsticks make...
Thud thud thud thud...................
My mother-in-law got the moderna, I really worry about her. She was an other wise healthy woman in her early 60’s and the media scared the crap out of her and she took it. My parents won’t touch any of the vaccines at this point, they deem them totally untested and as dangerous as covid.
My neighbor refused all vaccines. She’s six feet under now so no more worries. I was told she was on a vent in the morning. I knew she was a goner. She died 5 hours later. She died May 2. That covid is no joke for some people. I hope your mother in law stays clear.
Sorry I meant your parents. I hope they have a miracle.
How funny. I guess they all have issues one way or the other.
got any youtube video links?... 😁
“The one the Amish use. Whatever they are using has resulted in them being statistically untouched by COVID-19.”
Not quite. Theirs only works because they work and eat well. They also don’t ingest much MSM. Many here can’t seem to do that well. The only answer is to receive a toxic injection because they’re told to do so.
Leave all your ammo to me, I’ll be sure it goes to a good cause.
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