Posted on 06/05/2021 6:57:06 AM PDT by ConservativeMind
Several hormones and nutrients are known to influence the feeding neurocircuit in the hypothalamus. Classic examples are leptin and insulin, both involved in informing the brain of available energy. In the last years, the list of appetite- or satiety-triggering signals has been steadily growing with the identification of several gut hormones. Those are involved in fine-tuning feeding behavior by regulating the perception of hunger or satiety, ultimately leading to the initiation or termination of a meal. The gut-brain axis is thus a critical gatekeeper in regulating feeding behavior.
Bile acids are among the most abundant metabolites in the gut and act as versatile signaling molecules that relay nutrient availability to a physiological response by activating the bile acid responsive membrane receptor, Takeda G-coupled receptor 5 (TGR5).
…the authors showed that bile acids reach the mouse brain shortly after a meal to suppress food intake. Bile acids escape the digestive tract, transiently accumulate in the blood circulation, and spike in the hypothalamus for a very short period of time after feeding. The authors demonstrated that the anorexic response of bile acids is mediated by TGR5, located at the cell surface of a distinct group of hypothalamic cells, called AgRP/NPY neurons. When focusing on this neuronal subpopulation, they found that bile acids mediate two processes staggered in time. "While bile acids acutely block the release of appetite-stimulating AgRP and NPY peptides during the first minutes following binding of their cognate receptor, they further reinforce the repression by blunting the expression of these neurotransmitters," says Alessia Perino, first-author of the paper.
Over the last two decades, bile acids have been proven to be efficacious in alleviating chronic metabolic and inflammatory disorders.
(Excerpt) Read more at medicalxpress.com ...
If our bodies do not make enough bile (due to gallbladder or liver issues), it can be supplemented.
Look into TUDCA, Ox Bile, or similar supplements like “Bile Acid Factors” (Jarrow and others).
Interestingly, supplementing when eating fat can help repair parts of the defective processes, potentially freeing up your body’s ability to repair itself (of course, it does not cause a removed gallbladder to regrow).
Thank you for the massive tip. How do you use them? Do you just eat some in the AM, eat them with a meal?
They may be over thinking this. Too much bile acid curbs the appetite because Maalox foams in your mouth. Though this might explain Joe Biden’s problem.
Thanks
I am always hungry, always. I eat a LOT, but seem to hold my weight at 265. A little overweight, but far from obese despite the calories I consume, mostly protein. Maybe I don’t have a lot of gall, even though I’ve been accused repeatedly.
Ck out lactobacillus reuteri 30242. I’ve been using it for about two years and have lowered my bad cholesterol levels and my weight by about 15 lbs. without even trying. This stuff has something to do with increasing bile salts.
Why else would I have such strange dreams after a late-night meal of pizza?
I just saw a study that said men who took the drugs used to block bike acids (for reducing triglycerides) have a higher incidence of dementia. Whether this is cause or correlation, who knows?
It is disgusting we have allowed ourselves to believe the best option to address our terrible habits is to take a drug that breaks another needed process.
You would eat them with a fatty meal, so maybe start with one capsule and see if your body can handle that, then find the amount you can tolerate proportional to your incremental fat intake.
I believe TUDCA may not need food, but the other bile components likely do, with that food having fat.
Bile byproducts come from bacteria further breaking down the bile emulsified fat products.
So what are the implications for those who have had their gall bladder removed?
I believe doctors tell patients to supplement with ox bile or to limit fats.
So the crude hack doctors who just cut out someone’s gallbladder when it stones are setting the person up with a dummy wammy for life long weight issues. No bile to help break down extra fat and no appetite curbing.
Well, when you have a grossly inflamed gallbladder or burst gallbladder, you have to take it out to save a life.
However, there are legitimate ways to fix gallbladder and liver issues through eating/supplements/exercise, rather than taking a drug that doesn’t address root cause or having surgery to not have to have a healthier practice.
Oil will also curb appetite. Fish oil, cod liver oil, etc.
Bile acid gets reabsorbed by liver-produced cholinesterase downstream in the digestive tract. Interestingly acetyl cholinesterase is the enzyme which nerve junctions use to squelch nerve impulses after they pass.
Some poster already pointed out that triglycerides are necessary for adipose fat production. Excess circulating triglycerides result from a glycated liver’s inability to turn them into healthy cholesterol particles.
Do note that if on a Standard American Diet, dysfunctions in gut bacterial colonies can make too much of certain bile byproducts—byproducts that are truly needed, but need to be properly handled by your gut bacteria and body:
Western diet may increase risk of gut inflammation, infection
https://freerepublic.com/focus/f-chat/3965313/posts
You are so right. Since I started the keto diet about 3 years ago, my triglycerides are quite low and my blood sugar is normal. I’ve also dropped a lot of weight, although I never hit my goal and am now struggling to maintain. I am still much better off that I was before, though.
Then there is this:
Prescription to sit less, move more advised for mildly high blood pressure and cholesterol
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