A great piece of news from the Ivermectin Global Summit:
The Bryant-Lawrie Cochrane-standard (i.e. gold standard) review and meta-analysis of ivermectin has been accepted for publication.
Posted on 05/23/2021 9:01:02 PM PDT by SeekAndFind
New Delhi: Amid the rising coronavirus cases in the country, one drug that has almost become a household name is – Ivermectin. However, the medical fraternity is divided on its use amid lack of strong evidence of its success in treating COVID-19.
Ivermectin is mainly prescribed for patients with mild to moderate infection. With the second wave raging upon us, there was a huge surge in demand for these drugs. Dr Chandrashekhar T, Chief Intensivist, Fortis Hiranandani Hospital, Vashi has now cleared the air around its use, points to consider and more.
Recently, World Health Organisation (WHO) issued guidelines saying Ivermectin should only be used on COVID19 patients in clinical trial settings. The UN health agency said there was a “very low certainty of evidence” on Ivermectin’s effects on mortality, need for hospital admission and getting rid of the virus from the body. After which, many state governments in India have rejected its use for COVID19 patients.
The mechanism of action has not been explained here; this has caused confusion and worry among patients and providers alike.
But Dr Chandrashekhar says that there is enough evidence that show the effectiveness of Ivermectin. He says, “A study published in the American Journal of Therapeutics clearly mentions of a large majority of randomized and observational controlled trials of Ivermectin that reported repeatedly on the large magnitude improvements in clinical outcomes.”
“Numerous prophylaxis trials demonstrate that regular Ivermectin use leads to large reductions in transmission. Moreover, a comprehensive review of the available efficacy data as of December 12, 2020, taken from in-vitro, animal, clinical, and real-world studies. all show the above impacts of Ivermectin in COVID19,” he adds.
* Since 2012, multiple in-vitro studies have demonstrated that Ivermectin inhibits the replication of many viruses, including Influenza, Zika, Dengue, and others.
* Ivermectin inhibits SARS-CoV-2 replication and binding to host tissue through several observed and proposed mechanisms.
* Ivermectin has anti-inflammatory properties that prevents viral replication.
* Clinical studies of the efficacy of Ivermectin in hospitalized patients show favorable outcomes.
* Exposure prophylaxis studies that showcase Ivermectin’s ability to help prevent transmission of COVID19.
* Ivermectin hastens recovery and prevents deterioration in patients with mild to moderate disease, treated early after symptoms.
* The World Health Organization has long included Ivermectin on its “List of Essential Medicines”.
* However, there are studies that suggest the need for controlled studies to better test efficacy in Vexing Syndrome.
Having said that, the doctor explains that anything used in excess or abused is harmful to health, and rightly so. He is of the view that providers need to be careful while prescribing these drugs as they are still under review. “The best way is to be wise and not let panic take precedence over our logical reasoning. Most of these repurposed drugs have their own pros and cons when used for COVID19, this needs to be explained to the patients while prescribing it,” Dr Chandrashekhar says.
He further adds, “We have to be cautious but wise too. Let us all make an informed choice an ensure that we all come out of this crisis stronger and more empowered.”
(Disclaimer: The views expressed here are solely of the author, Dr Chandrashekhar T, Chief Intensivist, Fortis Hiranandani Hospital, Vashi)
Ping for your interest
India’s official alleged covid death toll is equal to approx SIXTY THOUSANDS covid deaths in US. yet US has around SIX HUNDRED THOUSAND DEATHS.
yes, India might, probably is, under-counting, but so what? the whole India covid beat-up is just another stage in the virus propaganda saga, pushed by FakeNewsMSM, politicians, ‘experts’...and lapped up by much of the public! unbelievable.
Have an illuminated holy family statue of Joseph and Mary holding baby Jesus and a sign reading FOR AMERICA PRAY THE ROSARY facing the state highway which is our access and fronts our property lighted by red, white, and blue led lights.Plus have a lighted flag on pole close by.
When saying daily it I Include a dedication that where ever Invemectin is being used it be successful
That’s nice!🙂🙏
>>However, the medical fraternity is divided on its use amid lack of strong evidence of its success in treating COVID-19.
BS. What we have here is medical policy being made by Big Pharma, and the Public Health Authorities are in on it via patent ownership. Does anyone think that a good idea?
Ivermectin for COVID-19: real-time meta analysis of 56 studies
Covid Analysis, Nov 26, 2020 (Version 83, May 18, 2021 — Merck analysis)
https://ivmmeta.com/
Big Pharma is knocking down Ivermectin - Senator Mitt “Big Pharma Whore” Romney voted to keep Dr. Kory from testifying about the drug last December. Romney took money from Big Pharma - and he traded that for lives. He tried to block Ivermectin. Yet he lectures us on the supposed immorality of Donald Trump.
I looked briefly at one study on Ivermectin (can’t remember where I saw it) which reported about a 75% positive response to Ivermectin. They were using a single dose of Ivermectin of I believe 5 mg. Other users of Ivermdectin have recommended 5 days of 12 mg. a day. I wonder if the other 25% could have been saved with a higher dose?
I’m seeing slightly better results at the meta study here:
The protocols I’m seeing are a little more granular than just 12mg on dosing. See here, especially the table at the top of p2. And note they talk about doing 2X the table’s dosage in certain situations.
IANADNDIPOOTV, but it seems you’d have to work pretty hard to OD with this stuff, based on what I’ve read. And the overall safety profile is something like Tylenol or Aleve. It really ought to be OTC, and sort of is if you don’t mind using veterinary products.
I have now looked at the link at Comment 4 which lists a number of studies and their dosages for treatment or control. I have to go back a look some more, but at quick glance, some seem lower or much lower than the 12 mg. a day for 5 days I have seen elsewhere. You might want to look over those studies yourself and we could compare notes. By the way, what is IANADNDIPOOTV?
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