Ivermectin: Modes of action against SARS-CoV-2 virus replication (Mody et al)
Posted on 05/19/2021 12:37:15 PM PDT by SeekAndFind
New insights into the mode of action of ivermectin against the novel SARS coronavirus.
The previously discussed, WHO-sponsored meta-analysis of ivermectin against covid-19 has now been published as a preprint. It found a highly significant 75% reduction in covid mortality, based on randomized controlled trials only, and will be continually updated with additional trial results.
To date, the mode of action of ivermectin against SARS-CoV-2 has remained somewhat of a mystery. Early studies indicated that ivermectin may inhibit viral protein transportation. But a new US-Canadian study, published in Nature Communications Biology, found that ivermectin is highly effective (>90%) in inhibiting the main enzyme (3CLpro) involved in the replication of SARS-CoV-2 and other RNA viruses (see the chart above).
Another study, submitted to the Journal of Structural Chemistry, found that ivermectin is binding to the spike protein of SARS-CoV-2 and thus may act as a generic antibody. This might explain why ivermectin appears to be highly effective even as a prophylaxis against SARS-CoV-2 infection.
Nevertheless, many patients, and even doctors, continue to be denied access to low-cost and safe ivermectin, especially in Western countries. Others are paying obscenely overcharged prices, visit dubious online merchants, or resort to animal-grade products. If ivermectin is not available locally, it may instead be bought from certified Indian pharmaceutical exporters on Indiamart. However, please note that some countries may not allow its importation.
100 tablets of 12mg ivermectin, enough to treat up to 50 people, cost about $50. And even if SARS-CoV-2 continues to mutate, ivermectin, targeting its replication, should remain effective. The same applies to other early treatment drugs targeting virus entry, replication, or disease progression.
Note: Patients are asked to consult a doctor.
Ivermectin: Modes of action against SARS-CoV-2 virus replication (Mody et al)
It will also get rid of intestinal worms if those are a problem for you.
At least, it works for our beagles.
Of course, they like to lick the butt too.
It does have an apple flavor, not bad at all.
All of the real world data could be just coincidental. We had a steep drop off last summer only to surge again in winter. Right now we are heading to summer and see a steep drop off but they claim it’s due to vaccines. Maybe it is. The trial data suggests the vaccines reduce risk greatly. But it seems most of the new cases even now are happening in the states up north where they say that, due to the earth’s angle facing the sun, there isn’t enough sun exposure to enable the body to produce enough vitamin D far north - north of the 40th degree parallel.
Doesn’t explain Italy, though, so there is contrary evidence to examine.
Just data to throw into the mix. I don’t have the answers, just some clues to follow. FWIW, much of Europe suffers the same because they are also far north.
Here you go.....follow the shot, for the post-vax death increases.....
Cost of (human) pill form of Ivermectin has gone up, over the months.
Gee.....I wonder why 🤔
Best to shop around, and have your doc call in Rx to one with competitive pricing.
There are notches on the plunger according to weight. Each brand is different. The one I have is measured double compared to that brand. So I will squeeze out a bead and cut it in half....and mix it with honey.
Where do you think 80% of our drugs come from, India and China.
I got all I wanted from India
I don’t believe in coincidence much. Most folks north if the 35th don’t get enough vitamin D, which is a critical part of staying healthy.
Yeah but horses weigh a lot more than humans. I haven’t seen these syringes but I can envision what you are saying. I know the dose is calculated in mg/kg, and I suppose a newborn foal might use less than her mare, closer to that of a full grown human, thus the notches. Those notches probably help a lot with measuring. The thing is, different protocols for prevention vs treatment. Maybe not dramatically different.
And ivermectin doesn’t care which variant (mutation) it’s dealing with (within reason).
The dose per weight is the same for a horse as a human. So a 1250 pound human would use the entire tube of the Durvet brand.
I’m about 200 pounds so I just took a ruler and marked the plunger into 6 different equal lengths and plunged it to the mark for each dose. As a preventative it was two doses spaced 48 hours apart to begin with and then a dose every two weeks.
By chance I had a physical a month after I started and my chronic low white blood count was even lower. I looked it up and that is a side effect of Ivermectin. No adverse physical issues. The low WBC is probably from something else, but in retrospect it may have been better to work with a doctor (online?) than trying to self medicate.
Thanks JL.
I’m sure the usual people will just find a way to say it’s faked or some such. Based on what I’ve seen locally it makes sense though.
Yup. Some of this stuff becomes obvious if you just pay attention. Why they put iodine in salt, for example.
Bflr
Good info. Thanks.
And that boys and girls explains why you can't have it.
So they believe (and apparently have demonstrated) that ivermectin acts as a 3CL Protease Inhibitor. There are a few other drugs that can do this, as well as a couple more being trialed. I read a study a while back that determined that while coronaviruses were able to mutate and reproduce around 3CL inhibitors, that the resulting mutations were significantly weaker and reproduction reduced.
Here’s a link with the full study. Lots of info on 3CL PI’s, including ivermectin. WARNING: long, geeky link below.
Researchers have known for some time that 3CL PI’s are a potential treatment against coronaviruses. In fact, Pfizer’s 3CL PI currently in trials is based on a molecule they were developing for SARS-1 back in 2003, but the virus disappeared and the project was shelved. I’m not yet fully convinced on the efficacy of ivermectin vs COVID in the real world, but it looks hopeful.
Thanks for that info!
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