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Clinical trial confirms breakthrough treatment for COVID-19: Patients with a self-administered nasal spray found to have reduced SARS-CoV-2 viral load by more than 95% in infected participants within 24 hours
Premium Times ^ | 04/16/2021

Posted on 04/16/2021 7:44:44 PM PDT by SeekAndFind

Randomized, double-blind, placebo-controlled trial evaluated 79 confirmed cases of COVID-19, the majority heavily-infected with the UK variant.


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British Columbia Biotech company SaNOtize Research & Development Corp., (SaNOtize https://sanotize.com/covid-19/ ), Ashford and St Peter’s Hospitals NHS Foundation Trust in Surrey, UK, and Berkshire and Surrey Pathology Services, UK, on Thursday announced results of clinical trials indicating that SaNOtize’s Nitric Oxide Nasal Spray (NONS) represents a safe and effective antiviral treatment that could prevent the transmission of COVID-19, shorten its course, and reduce the severity of symptoms and damage in those already infected.

In a randomized, double-blind, placebo-controlled Phase 2 trial that evaluated 79 confirmed cases of COVID-19, SaNOtize’s early treatment for COVID-19 significantly reduced the level of SARS-CoV-2, including in patients with high viral loads. The average viral log reduction in the first 24 hours was 1.362, which corresponds to a decline of about 95%. Within 72 hours, the viral load dropped by more than 99%. The majority of these patients had been infected with the UK variant, which is considered a variant of concern. There were no adverse health events recorded in the UK trial, or in over 7,000 self-administered treatments given in earlier Canadian clinical trials.

NONS is the only novel therapeutic treatment so far proven to reduce viral load in humans that is not a monoclonal antibody treatment. Monoclonal antibodies are highly specific, expensive and must be administered intravenously in a clinical setting.

“I expect this to be a major advance in the global battle against the devastating human impacts of the COVID-19 pandemic,” said Dr. Stephen Winchester, Consultant Medical Virologist and Chief Investigator of this NHS Clinical Trial. “This simple portable nasal spray could be highly effective in the treatment of COVID-19 and reducing onward transmission. Our trial included patients with a variant of concern and high viral loads yet still demonstrated significant reductions in the levels of SARS-CoV-2, which could be critical in supporting vaccines, preventing future outbreaks and safely reopening economies. Simply stated, I think this could be revolutionary.”

The SaNOtize treatment is designed to kill the virus in the upper airways, preventing it from incubating and spreading to the lungs. It is based on nitric oxide (NO), a natural nanomolecule produced by the human body with proven anti-microbial properties shown to have a direct effect on SARS-CoV-2, the virus that causes COVID-19. The pharmacology, toxicity, and safety data for NO use in humans has been well-established for decades. The NO molecule released from NONS is identical to the one delivered in its gaseous form to treat persistent pulmonary hypertension, or Blue Baby Syndrome, in newborn babies.

SaNOtize Seeking Emergency Use Authorization in UK and Canada

SaNOtize is applying to regulatory authorities in the UK and Canada for Emergency Use authorization. Swift approval and ramp-up of manufacturing could facilitate an almost immediate safe return to work, school and society, and spur an economic recovery that is months – if not years – ahead of full global vaccination.

Wide-scale equitable global availability of NONS could form a bridge during the global production and distribution of vaccines to help keep people safe and healthy. The ease of NONS manufacture, storage and use makes NONS a treatment candidate that could soon be widely available at low-cost for long-term care facilities, healthcare and frontline workers, and the general population.

In addition to providing antiviral treatment in the early stages of infection and for those who have yet to be vaccinated, NONS has also demonstrated that it could also reduce infectivity – the frequency of transmission from an infected person to a non-infected person.

The results of the UK trial corroborate the information gathered from SaNOtize’s earlier Phase 2 trials in Canada and independent lab tests at Utah State University’s Antiviral Research Institute.



TOPICS: Health/Medicine; Science; Society
KEYWORDS: chinavirustreatment; clinicaltrial; covid19; nasalspray; sanotize
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1 posted on 04/16/2021 7:44:44 PM PDT by SeekAndFind
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To: SeekAndFind

The globalists are going to hate this...


2 posted on 04/16/2021 7:50:23 PM PDT by Aria (- )
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To: SeekAndFind

Impressive amd good news.

Combine with Ivermectin and HCQ therapies and lets put this ChiCom Virus behind us.


3 posted on 04/16/2021 7:50:59 PM PDT by romanesq (TRUSTY THE PLAN! ChiCom Joe is the Plan? Que magnificent! 👹)
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To: SeekAndFind

I have used a saline nasal spray for several years. It has cut the number of nose bleeds way down due to the dry conditions I worked with. And helped with colds.

Currently Vicks Sinex

https://www.amazon.com/Vicks-EVERYDAY-SALINE-DRUG-FREE-Congestion/dp/B0886WL3YV/ref=sr_1_4?crid=TL1CFHFIY9AQ&dchild=1&keywords=vicks+sinex+nasal+spray&qid=1618627844&sprefix=vicks+sine%2Caps%2C225&sr=8-4


4 posted on 04/16/2021 7:52:33 PM PDT by dynachrome ("I will not be reconstructed, and I do not give a damn.")
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To: SeekAndFind

IBDSM - in before Dr. Straw Man


5 posted on 04/16/2021 7:53:49 PM PDT by TigersEye (Will the Younger Dryas Impact you? )
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To: SeekAndFind

Joker gas.😁


6 posted on 04/16/2021 7:56:18 PM PDT by BiteYourSelf ( Earth first we'll strip mine the other planets later.)
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To: SeekAndFind

I saw this somewhere else earlier today- it’s great news- more of this please!! I think there has to be a ‘cure’, ‘antidote’ or treatment because it’s completely illogical that the leftists in charge running this ‘show’ haven’t become ill or been affected by it!!!! Think about that! (Or did I miss it, and someone has?)


7 posted on 04/16/2021 7:56:53 PM PDT by dkGba (God Bless America dkGba)
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To: SeekAndFind

BTTT!!!


8 posted on 04/16/2021 7:58:24 PM PDT by musicman (The future is just a collection of successive nows.)
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To: Aria

The summary is somewhat misleading. It seems to demonstrate that spraying nitric oxide into your nose reduces the number of viruses in your nose.

That’s helpful, but it would be much more important to clear the virus from the lungs.


9 posted on 04/16/2021 8:00:32 PM PDT by Renfrew
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To: SeekAndFind

Big Brother will still require face masks.

After all, it’s only “ 95 % effective “. That means that the .01 victims still have a 5 % chance of catching the virus.


10 posted on 04/16/2021 8:00:41 PM PDT by BrexitBen
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To: SeekAndFind

Dr.Fauxi says it doesn’t work and to shut up and wear your mask. Masks.


11 posted on 04/16/2021 8:03:18 PM PDT by bigbob
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To: Renfrew
The summary is somewhat misleading. It seems to demonstrate that spraying nitric oxide into your nose reduces the number of viruses in your nose. That’s helpful, but it would be much more important to clear the virus from the lungs.

The nose is the first place the virus goes is it not?

12 posted on 04/16/2021 8:04:45 PM PDT by FreeReign
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To: Aria

So will Big Pharma. Look for bogus testing done by supposedly independent parties to show this new treatment to have “no impact” on reducing the SARS-CoV-2 viral load and “possibly dangerous side effects” on those using this treatment.


13 posted on 04/16/2021 8:05:31 PM PDT by princeofdarkness ( )
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To: SeekAndFind

Fauxi is NOT gonna be happy- It will be Poo-Pooed, and outlawed, just like Hydrochloroquine, Ivermectin and all the rest. The closedowns, face-burquas, semiannual vaccinations will be a permanent way of life.


14 posted on 04/16/2021 8:06:28 PM PDT by matthew fuller (Reserved)
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To: Aria

Similar stats for Ivermectin, yet we have all these sick people in hospitals not even offered it.


15 posted on 04/16/2021 8:06:31 PM PDT by inchworm (al )
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To: SeekAndFind
Vindicated. But it will be buried just like all the rest, including PG:

Wuhan Coronavirus: Propylene Glycol as Possible Therapy for Eradication of RTI and Prevention of Complications [vanity]

16 posted on 04/16/2021 8:13:03 PM PDT by logi_cal869 (-cynicus the "concern troll" a/o 10/03/2018 /!i!! &@$%&*(@ -)
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To: FreeReign

“The nose is the first place the virus goes is it not?”

I think it’s the most common entry point, though it can infect through everything from your eyes to your gut.

Even with the nose, do you notice you are sick and start the treatment in time before it hits your lungs?

Overall it seems like this is a treatment that may help, but won’t be a miracle cure to all COVID.


17 posted on 04/16/2021 8:16:24 PM PDT by Renfrew
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To: TigersEye

😂😂😂


18 posted on 04/16/2021 8:19:28 PM PDT by Jane Long (America, Bless God....blessed be the Nation 🙏🏻🇺🇸)
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To: romanesq

If there are alternatives, the emergency waiver for the mRNA is at risk.

Big pharm will deny this study.


19 posted on 04/16/2021 8:20:14 PM PDT by ptsal (Vote R.E.D. >>>Remove Every Democrat ***)
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To: Renfrew

I guess all those COVID tests using the long swabs were doing it wrong, who knew a simple nasal swab would be sufficient for a COVID test?


20 posted on 04/16/2021 8:22:28 PM PDT by kingu (Everything starts with slashing the size and scope of the federal government.)
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