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Clinical trial confirms breakthrough treatment for COVID-19: Patients with a self-administered nasal spray found to have reduced SARS-CoV-2 viral load by more than 95% in infected participants within 24 hours
Premium Times ^ | 04/16/2021

Posted on 04/16/2021 7:44:44 PM PDT by SeekAndFind

Randomized, double-blind, placebo-controlled trial evaluated 79 confirmed cases of COVID-19, the majority heavily-infected with the UK variant.


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British Columbia Biotech company SaNOtize Research & Development Corp., (SaNOtize https://sanotize.com/covid-19/ ), Ashford and St Peter’s Hospitals NHS Foundation Trust in Surrey, UK, and Berkshire and Surrey Pathology Services, UK, on Thursday announced results of clinical trials indicating that SaNOtize’s Nitric Oxide Nasal Spray (NONS) represents a safe and effective antiviral treatment that could prevent the transmission of COVID-19, shorten its course, and reduce the severity of symptoms and damage in those already infected.

In a randomized, double-blind, placebo-controlled Phase 2 trial that evaluated 79 confirmed cases of COVID-19, SaNOtize’s early treatment for COVID-19 significantly reduced the level of SARS-CoV-2, including in patients with high viral loads. The average viral log reduction in the first 24 hours was 1.362, which corresponds to a decline of about 95%. Within 72 hours, the viral load dropped by more than 99%. The majority of these patients had been infected with the UK variant, which is considered a variant of concern. There were no adverse health events recorded in the UK trial, or in over 7,000 self-administered treatments given in earlier Canadian clinical trials.

NONS is the only novel therapeutic treatment so far proven to reduce viral load in humans that is not a monoclonal antibody treatment. Monoclonal antibodies are highly specific, expensive and must be administered intravenously in a clinical setting.

“I expect this to be a major advance in the global battle against the devastating human impacts of the COVID-19 pandemic,” said Dr. Stephen Winchester, Consultant Medical Virologist and Chief Investigator of this NHS Clinical Trial. “This simple portable nasal spray could be highly effective in the treatment of COVID-19 and reducing onward transmission. Our trial included patients with a variant of concern and high viral loads yet still demonstrated significant reductions in the levels of SARS-CoV-2, which could be critical in supporting vaccines, preventing future outbreaks and safely reopening economies. Simply stated, I think this could be revolutionary.”

The SaNOtize treatment is designed to kill the virus in the upper airways, preventing it from incubating and spreading to the lungs. It is based on nitric oxide (NO), a natural nanomolecule produced by the human body with proven anti-microbial properties shown to have a direct effect on SARS-CoV-2, the virus that causes COVID-19. The pharmacology, toxicity, and safety data for NO use in humans has been well-established for decades. The NO molecule released from NONS is identical to the one delivered in its gaseous form to treat persistent pulmonary hypertension, or Blue Baby Syndrome, in newborn babies.

SaNOtize Seeking Emergency Use Authorization in UK and Canada

SaNOtize is applying to regulatory authorities in the UK and Canada for Emergency Use authorization. Swift approval and ramp-up of manufacturing could facilitate an almost immediate safe return to work, school and society, and spur an economic recovery that is months – if not years – ahead of full global vaccination.

Wide-scale equitable global availability of NONS could form a bridge during the global production and distribution of vaccines to help keep people safe and healthy. The ease of NONS manufacture, storage and use makes NONS a treatment candidate that could soon be widely available at low-cost for long-term care facilities, healthcare and frontline workers, and the general population.

In addition to providing antiviral treatment in the early stages of infection and for those who have yet to be vaccinated, NONS has also demonstrated that it could also reduce infectivity – the frequency of transmission from an infected person to a non-infected person.

The results of the UK trial corroborate the information gathered from SaNOtize’s earlier Phase 2 trials in Canada and independent lab tests at Utah State University’s Antiviral Research Institute.



TOPICS: Health/Medicine; Science; Society
KEYWORDS: chinavirustreatment; clinicaltrial; covid19; nasalspray; sanotize
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To: SeekAndFind

Seems to be the real deal.
Lots of studies going on, with impressive success.


21 posted on 04/16/2021 8:24:09 PM PDT by mrsmith (US MEDIA: " Every 'White' cop is a criminal! And all the 'non-white' criminals saints!")
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To: dkGba

Likely meds/treatments like this and the HCQ or Ivermectin.

PeLOUSY: Good for ME, but NOT for thee.


22 posted on 04/16/2021 8:25:08 PM PDT by Jane Long (America, Bless God....blessed be the Nation 🙏🏻🇺🇸)
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To: logi_cal869

Are nitric oxide and propyl glycol the same thing? 🤔

Your ordeal was something. It would seem that ivermectin would be a much easier course of treatment.

Good for you for healing yourself.


23 posted on 04/16/2021 8:27:55 PM PDT by Jane Long (America, Bless God....blessed be the Nation 🙏🏻🇺🇸)
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To: SeekAndFind

What stock symbol please and now I’ll do my due diligence and read all the comments of course. .

Bump. ;-)


24 posted on 04/16/2021 8:34:57 PM PDT by Tunehead54 (Nothing funny here ;-)
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To: Renfrew

An article the other day reported budesonide also is preventive; it’s an otc generic for Nasacort, a steroid nasal spray. We use generic Flonase but I’m thinking of switching to budesonide.


25 posted on 04/16/2021 8:37:41 PM PDT by Flaming Conservative ((Pray without ceasing);)
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To: Tunehead54

https://m.jpost.com/health-science/israeli-anti-viral-nasal-spray-gets-first-sales-approvals-662787


26 posted on 04/16/2021 8:38:31 PM PDT by Jane Long (America, Bless God....blessed be the Nation 🙏🏻🇺🇸)
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To: SeekAndFind

this sounds cool. Is there copper in the formula maybe?

“In the laboratory, nitric oxide is conveniently generated by reduction of dilute nitric acid with copper:

8 HNO3 + 3 Cu → 3 Cu(NO3)2 + 4 H2O + 2 NO

(wiki)


27 posted on 04/16/2021 8:52:26 PM PDT by blueplum ("...this moment is your moment: it belongs to you... " President Donald J. Trump, Jan 20, 2017) )
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To: SeekAndFind

It’s silver. Bank on it


28 posted on 04/16/2021 9:03:36 PM PDT by Truthoverpower (Fraud !!! Now we’re off the TRUMP TRAIN and on the Swamp express to communist hell !! TRUTH! )
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To: Tunehead54

Lot of companies are in trials.
You’ll have to guess which ones get the contracts.


29 posted on 04/16/2021 9:14:27 PM PDT by mrsmith (US MEDIA: " Every 'White' cop is a criminal! And all the 'non-white' criminals saints!")
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To: Jane Long

Yes - in terms of their corresponding usage as disinfectants - they are the same: Non-pharmacological viral intervention.

I was ill long before any discussion of Ivermectin. My vape pouch is in my medicine cabinet now for any development of respiratory illness.

The working theory at the time - based upon my long ago discovered 1960s research into PG use for influenza - was that as a respiratory disinfectant PG would reduce viral load and speed recovery without side effects.

NO is also a disinfectant, though it’s not clear about the timeline for intervention for a simple nasal application to be effective. The article does state “designed to kill the virus in the upper airways, preventing it from incubating and spreading to the lungs.” In my own case it would have been wholly ineffective had I not engaged such a nasal spray 24 hours prior to initial symptoms, at which point I was already enduring coughing and, within hours high fever. Thus I would had to have been using Sanotize for no other reason than a preventive.

It’s also clear from the article that they are pursuing OTC, as well as promoting Sanotize for flu & sinusitis as well.

They don’t state it, but it’s clear in the current environment that if this is OTC that it will be overused by many as a perceived prophylaxis against a virus which is less deadly to those under 49 than the risk of dying by falling. In that respect it’s a brilliant cash cow. Definitely a stock to watch.

Irony: It would probably be more effective with the elderly than the ‘vaccines’.


30 posted on 04/16/2021 9:18:34 PM PDT by logi_cal869 (-cynicus the "concern troll" a/o 10/03/2018 /!i!! &@$%&*(@ -)
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To: Renfrew

The idea is to treat it very early. If you can recognize you might have more than a cold, get tested, get the results, get prescribed...

Took me three days to get tested when I was exposed, five days more to get the results. Worthless.


31 posted on 04/16/2021 9:19:43 PM PDT by heartwood (Someone has to play devil's advocate other.)
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To: ptsal
If there are alternatives, the emergency waiver for the mRNA is at risk.

A bit late for that, the horses have all left the barn and have been mass produced and injected into tens of millions of Americans.

And it wasn't exactly a big problem for them last year to deny the existence of numerous effective alternatives that, by the CDC's and FDA's own rules, should have prevented any emergency fast-tracking.... which most Republicans now celebrate as Pres Trump's Operation Warp Speed.

32 posted on 04/16/2021 9:31:16 PM PDT by Teacher317
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To: SeekAndFind

I read this week where Israel is the country that came up with this treatment. And they use purified water with a drop of Hydrogen peroxide in it. They are having unbelievable results.


33 posted on 04/16/2021 9:49:58 PM PDT by native texan
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To: dynachrome
I have used a saline nasal spray for several years.

I use Nano-silver gel in my nose. Kills germs and viruses. Keeps me healthy.

34 posted on 04/16/2021 10:34:29 PM PDT by stars & stripes forever (Blessed is the nation whose God is the Lord. (Psalm 33:12))
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To: dynachrome

Interesting!


35 posted on 04/16/2021 10:42:28 PM PDT by Freedom56v2 (If I wanted to live in China, I would move there!)
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To: SeekAndFind

Bttt


36 posted on 04/16/2021 10:58:28 PM PDT by Eagles6 (Welcome to the Matrix circa 1984.)
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To: logi_cal869

You use propylene glycol to deice aircraft. It’s also toxic to the body.

I deiced aircraft for one winter.


37 posted on 04/16/2021 11:14:40 PM PDT by wastedyears (The left would kill every single one of us and our families if they knew they could get away with it)
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To: SeekAndFind

I hope this very little known nasal spray does not cause some do-it-yourselfers to grab the bleach bottle or the aquarium cleaner.


38 posted on 04/16/2021 11:56:22 PM PDT by jonrick46 ( Leftnicks chase illusions of motherships at the end of the pier.)
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To: matthew fuller
HCQ and Ivermectin are both legal for prescription specifically for treating Covid-19. Double-checked by our Indiana State legislator, a pharmicist and owner of a pharmacy in Salem, Indiana. State Department of Health confirms physicians may prescribe these.

The problem in our area is that there are few doctors in private practice, and the CDC and NIH puts pressure on the employers, hospital systems, to forbid their doctors from prescribing HCQ and Ivermectin.

We are making a big stink about this here.

39 posted on 04/17/2021 12:10:24 AM PDT by John Leland 1789
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To: Flaming Conservative

Rhinocort nasal spray is budesonide, I think.


40 posted on 04/17/2021 3:24:57 AM PDT by FamiliarFace
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