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Merck plans large outpatient trial of COVID-19 pill, Molnupiravir, stops study in hospitalized patients
Reuters via Yahoo News ^ | 04/15/2021 | Deena Beasley

Posted on 04/15/2021 11:01:33 AM PDT by SeekAndFind

Merck & Co Inc on Thursday said it plans a large study of what could become the first pill to target the coronavirus in people at risk of severe COVID-19, but will no longer pursue use of the experimental antiviral drug in hospitalized patients.

The company said it would study the drug molnupiravir in a Phase 3 trial among COVID-19 patients out of hospitals who have at least one risk factor for poor outcomes, such as advanced age, obesity or diabetes.

Trial participants can have had symptoms for no more than five days, shortened from seven days in a prior study.

"We had some encouraging signals in the outpatient trial. That was not the case in the inpatient trial, but that was not unexpected," Roy Baynes, Merck's chief medical officer, told Reuters. He said COVID-19 patients who need hospital treatment are often in the "inflammatory" phase of the disease, which is too late for an antiviral drug to provide much help.

Molnupiravir, which Merck is developing with Ridgeback Biotherapeutics, is designed to interfere with the ability of the coronavirus to replicate.

Merck also said it discontinued development of an experimental immune modulator, known as MK-7110, for treating COVID-19 after concluding that clinical trial and manufacturing preparations would take too long.

The drugmaker earlier this year stopped development of two COVID-19 vaccines, citing data showing they were less effective than vaccines being developed by rivals.

Merck said its trials of molnupiravir found no drug-related adverse events that led participants to discontinue treatment and there were no drug-related deaths.

Patients in the Phase 3 trial will be given 800 mg of molnupiravir twice a day for five days.

Merck said it plans to present at an upcoming medical meeting details from earlier studies of the drug in both hospitalized and non-hospitalized patients.

(Excerpt) Read more at news.yahoo.com ...


TOPICS: Health/Medicine; Science; Society
KEYWORDS: chinavirustreatment; covid19; merck; molnupiravir; pill
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1 posted on 04/15/2021 11:01:33 AM PDT by SeekAndFind
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To: SeekAndFind

MORE HERE:

https://www.statnews.com/2021/04/15/merck-to-continue-tests-of-covid-pill-but-stop-trial-in-hospitalized-patients/

Roy Baynes, the chief medical officer at Merck Research Laboratories, said that a 302-patient study of molnupiravir in people with Covid-19 who have not been hospitalized has shown signs of benefit for the drug.

The percentage of patients who were hospitalized or died in the treatment groups was lower than in the placebo group, but Merck said “the number of events reported are not sufficient to provide a meaningful measure of clinical effect.”

Baynes said the medicine showed “a very clear antiviral effect.” Actual data will be presented at a medical meeting.


2 posted on 04/15/2021 11:09:13 AM PDT by SeekAndFind
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To: SeekAndFind

Oh goodie.
More poison


3 posted on 04/15/2021 11:09:42 AM PDT by SheepWhisperer (My enemy saw me on my knees, head bowed and thought they had won until I rose up and said Amen!)
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To: SeekAndFind

great now you need multiple vaccines AND a pill


4 posted on 04/15/2021 11:10:11 AM PDT by Secret Agent Man (Gone Galt; Not Averse to Going Bronson.)
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To: SeekAndFind

This sounds no different than the drug combination protocols that other doctors have been using such as Ivermectin+ and HCQ+. Give them to people within 5 days of diagnosis or symptoms.

But there is no money to be made on those drugs. So nobody funded a large study of them. Notice that they dropped the study on in-patient/hospitalized patients, and shortened it to 5 days from 7 days for symptomatic out patients only. Exactly the same protocol for the other drugs which the FDA refuses to endorse and many pharmacists refuse to fill.

Many of the “trials” that TPTB used to try to debunk HCQ+ and Ivermectin+ were done on hospitalized and ICU patients, and did not combine them with the minerals, vitamins and antibiotics. Merck is playing the hand TPTB dealt them.


5 posted on 04/15/2021 11:21:57 AM PDT by monkeyshine (live and let live is dead)
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To: SeekAndFind
Merck needs to be honest and make it a suppository...a painfully jagged one.

You'll be able to spot the virtue signalers by their walk and constant virtue-whining.

6 posted on 04/15/2021 12:21:08 PM PDT by T.B. Yoits
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To: SheepWhisperer

Will there ever be a vaccine or therapeutic that satisfies the anti science folks? First the vaccine. Nope. Never going to take it. Bill gates. Microchips. Gene therapy. Blah blah blah. All hysteria mind you. But fine. Don’t get the vaccine. Now a highly promising drug that treats the disease and you dismiss it as poison out of hand? I guess toj just want everyone to get covid and don’t care if people get chronic illness or die so you can advance your flat earth anti medicine agenda

It gets tiresome. Fast.


7 posted on 04/15/2021 12:46:27 PM PDT by gas_dr (Trial lawyers AND POLITICIANS are Endangering Every Patient in America: INCLUDING THEIR LIBERTIES)
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To: SeekAndFind

Big Pharma has $$$o much to gain from the Scamdemic.

Meanwhile,HCQ and Ivermectin pills should be in gumball machines everywhere,for $0.50 each. No scrip needed.


8 posted on 04/15/2021 1:07:57 PM PDT by Basket_of_Deplorables (Convention Of States is our only hope now!)
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To: gas_dr

“Anti science”

Ha!

...and all the science that shows the dangers of being a lab rat in this nightmare? And the science that shows that NOBODY EVER has yet to create a successful corona virus vaccine?. I guess that’s not “real science” though.

...I get my vaccine daily...I eat healthy, take supplements that actually ARE tested and approved (you know, the ones where humans aren’t the real life lab rats until 2023), don’t wear a lemming face diaper, get sunshine and exercise.

It’s my daily dose of not poison.

I’ll wait until I see what happens to big pharma’s lab rats and see what their poison does to them first, before I ever volunteer to be part of their trials. It just make sense.

My dad used to say; “fools rush in where angels fear to tread”
.
...and something about no old bold pilots. I always loved to remind him about Chuck Yeager. He’d get mad =o)


9 posted on 04/15/2021 3:03:14 PM PDT by SheepWhisperer (My enemy saw me on my knees, head bowed and thought they had won until I rose up and said Amen!)
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To: SheepWhisperer

In other words, you have no clue what you are talking about, but form strong opinions and comment anyway. Narrative matters, not facts.


10 posted on 04/15/2021 3:29:20 PM PDT by Republican Wildcat
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To: Republican Wildcat

You tell us all when these “vaccines” are scheduled to complete their trial period ....mmmkay?

And if you don’t have the energy or honest to post it, you’re concealing the truth and have an agenda.

NONE of these poisons will be through the “trial” phase until the end of next year at the earliest and January ‘23 for the latest.

“Trial period” is the testing phase. And the test subjects are those who choose to be the experimental test subjects.

Now name the successful corona virus vaccine, for either animals or humans?

That’s right, there are none.

But if you want to be their lab rat, this is your choice. But don’t hate because others don’t believe the bs.

I’ll sit back and see what it does to you first.


11 posted on 04/15/2021 3:49:12 PM PDT by SheepWhisperer (My enemy saw me on my knees, head bowed and thought they had won until I rose up and said Amen!)
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To: Republican Wildcat

You haven’t posted a fact to me yet.

How’s THAT for a fact!


12 posted on 04/15/2021 3:50:37 PM PDT by SheepWhisperer (My enemy saw me on my knees, head bowed and thought they had won until I rose up and said Amen!)
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To: gas_dr

“Will there ever be a vaccine or therapeutic that satisfies the anti science folks? First the vaccine. Nope.”

Just when we appear to see green shoots of honesty from you, you post this.

FLCCC’s MATH+ hospital protocol, and their early/home treatment protocols, both of which combine conventional and nutritional approaches, would be examples of effective therapeutics which many of us support.

Then there are the (IIRC) two dozen or so therapeutics mentioned by Dr Peter McCullough MD to the TX Senate in late March.

Then there are the pure/mostly supplement approaches used by wellness MDs. Some of them might might add HCQ and Ivermectin. My own MD recommends quercetin instead of HCQ. Dr David Brownstein has been using nebulized supplements for years.

Then there are Frontline Doctors, who most of the medical people here seem to despise.

Perhaps you have not been paying attention, but social media, the regular media, conventional medicine and government agencies have greatly restricted any mention/use of these therapeutics. Dr McCullough mentioned that it was done in tandem by all the above as soon as there was talk of a vax. Have you heard McCullough’s talk? It is eye opening. I guess he’s probably a quack.

BTW nice try in conflating the vaccines (2 of which are already in question/suspended?) and therapeutics.

We’re not flat earthers. We just prefer not to die of a blood disorder, a serious allergic reaction, cancer, or develop an appetite for brains, when the virus is close to 100% survivable by anyone with vitD blood levels above about 50 ng/mL plus daily zinc intake.

Come to think of it, a zombie would have to be on a crash diet to be enticed by some of our FR medical brains. But that is another discussion.


13 posted on 04/16/2021 1:43:53 AM PDT by SecAmndmt (Aim small, miss small)
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To: ransomnote; bagster; metmom; Jane Long

Ping to post 7.


14 posted on 04/16/2021 1:46:20 AM PDT by SecAmndmt (Aim small, miss small)
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To: T.B. Yoits

Lol!


15 posted on 04/16/2021 1:57:08 AM PDT by Osagegirl
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To: gas_dr
I guess you just want everyone to get covid and don’t care if people get chronic illness or die so you can advance your flat earth anti medicine agenda.

Back to the fort, anti-vaxxers!

Time for a new plan!

16 posted on 04/16/2021 3:41:14 AM PDT by bagster ("Even bad men love their mamas".)
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To: Republican Wildcat
In other words, you have no clue what you are talking about, but form strong opinions and comment anyway. Narrative matters, not facts.

No. I think he said the right words. Maybe your hearing?

How old are you?


17 posted on 04/16/2021 3:44:21 AM PDT by bagster ("Even bad men love their mamas".)
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To: Republican Wildcat; gas_dr; SheepWhisperer
Lab Wabbits!


18 posted on 04/16/2021 3:49:50 AM PDT by bagster ("Even bad men love their mamas".)
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To: SheepWhisperer; Republican Wildcat
You haven’t posted a fact to me yet. How’s THAT for a fact!


19 posted on 04/16/2021 3:52:26 AM PDT by bagster ("Even bad men love their mamas".)
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To: SecAmndmt; gas_dr
Come to think of it, a zombie would have to be on a crash diet to be enticed by some of our FR medical brains. But that is another discussion.

Zing!!!

Gassy! You're taking too many punches. Stay away from him and keep your left up.

20 posted on 04/16/2021 3:58:41 AM PDT by bagster ("Even bad men love their mamas".)
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