Posted on 08/14/2020 7:31:12 AM PDT by SeekAndFind
This is a (quick) overview of key developments relating to Ivermectin as a therapeutic for COVID-19. We will provide additional coverage and hopefully interviews in the coming weeks.
The past days have brought considerable attention to Ivermectin as a cure for COVID-19, with several Sky News Australia articles and segments devoted to a treatment protocol comprising Ivermectin, Doxycycline and Zinc – promoted by Professor Borody from Australia.
Ivermectin is a generic drug, used both for humans and animals such as dogs and horses. It shares many characteristics with hydroxychloroquine: cheap, generic, widely available. Like with hydroxychloroquine, ivermectin-based treatments aim at curbing the development of the disease and at reducing the need for hospitalization when administered early. And like hydroxychloroquine, such cheap treatment is seen as a threat to more expensive non-generic therapeutics and to vaccines.
While there is much attention with Professor Borody’s interviews by Australian media, Ivermectin is not new when it comes to COVID-19 therapies. It’s actually in Australia that it all started, when research by scientists from Monash University published a pre-print on April 3 — “Possible coronavirus drug identified: Ivermectin stops SARS-CoV-2 virus growing in cell culture.”
The article, by Leon Caly, Julian D. Druce, Mike G. Catton , David A.Jans, and Kylie M. Wagstaff, was received on 18 March 2020, revised on 27 March 2020, accepted on 29 March 2020 and made available online on April 3rd 2020. It was then published in the journal Antiviral Research, Volume 178, in June 2020.
https://www.sciencedaily.com/releases/2020/04/200403115115.htm
(see further information about ivermectin, a drug used for several types of parasite infestations, including onchocerciasis and lymphatic filariasis, at this link.)
What happened following this publication is pretty remarkable. Within days, two medical doctors from Fort Lauderdale, FL, Dr. Jean-Jacques Rajter and Dr. Juliana Cepelowicz Rajter, decided to try the drug on hospitalized patients.
They figured out what would be a safe dosage for Ivermectin and tried it on a first patient, and just days later witnessed improvements, while the patient would probably have otherwise been transferred to the ICU, with a highly likely death as an outcome. Instead, the patient was discharged shortly after. Then they tried the therapy on another patient, with similar results, and then on another one …
It proved to be a pretty immediately successful trial and error process. Enthused by their results, seeing opportunities to save lives throughout the world, the doctors made their experience known to the media, which resulted in an April 13 report by NBC Miami.
“Two weeks ago, Dr. Rajter started adding Ivermectin to the cocktail of drugs currently used to treat COVID-19: hydroxychloraquine, azithromycin, and zinc sulfate.”
“Since then he’s treated dozens of people with this combination, with results so encouraging, he calls them remarkable.”
“If we get to these people early, and what I mean by that is if their oxygen requirements are less than 50%, I’ve had nearly a 100% response rate, they all improve, if they’re on more oxygen than that, then it becomes a little more varied, some people, they don’t respond anymore because they are too far advanced,” explained Dr. Rajter.
They also shared on social media, which triggered attention from numerous medical doctors from countries as diverse as Cuba, Egypt, the Dominican Republic, Iraq, Hungary, India, Japan, Peru, Bolivia, Bangladesh and India, to name just a few.
The two doctors carefully compiled their therapeutic results in view of an observational retrospective study, which became the so called ICON (Ivermectin in COvid Nineteen) study.
https://www.medrxiv.org/content/10.1101/2020.06.06.20124461v2
This sequence of events is nicely covered in this interview on TrialSite News.
Since then, lots of developments occurred regarding Ivermectin, which is now being used at various stages: prophylaxis, early treatment, and treatment of mild to moderately symptomatic patients.
This is important to note: time wise, ivermectin-based treatments appear to cover a wider therapeutic window than Hydroxychloroquine-based treatments.
On July 6, TrialSite News provided an update, with Ivermectin news from Bangladesh, the Dominican Republic, Singapore and India.
Of special interest is the study “A comparative observational study on Ivermectin- Doxycycline and Hydroxychloroquine-Azithromycin therapy on COVID19 patients” by Abu Taiub Mohammed Mohiuddin Chowdhury et al from Bangladesh.
According to this study, “both the Ivermectin-Doxycycline and HCQ-Azithromycin treatment regimens were found to be effective against SARS-CoV-2 infection.”
The authors note however that:
“concerning the treatment outcome, adverse effect and safety, Ivermectin-Doxycycline combination is superior to HCQ-Azithromycin therapy for mild to moderate degree of COVID19 patients”
Additional research has been conducted in various locations, including India. One of the latest developments is the decision by the State of Uttar Pradesh in India to replace Hydroxychloroquine with Ivermectin for the prevention and treatment of Covid-19.
In Brazil, Ivermectin is increasingly used, especially outside hospital settings. In this country, badly hit by the pandemic, it has gained large public attention. For example, this June 9 video featuring Dr Lucy Kerr and Dr Alain Dutra, has attracted over 1 million views. (you can use youtube’s subtitles auto-translate feature if you don’t command Portuguese)
As for Professor Borody, he interestingly emphasizes to combine Ivermectin with both Zinc and an antibiotic – Doxycycline.
Yet, from the reports by Sky News Australia, it appears that his potentially life-saving recommendations are falling on deaf ears at the level of the Australian bureaucracy – a typical pattern in most Western countries.
Remember, since March, NY Dr Zelenko also used a tritherapy, relying on an antibiotic – Azithromycin -, Zinc and hydroxychloroquine. You can view our landmark interview with Dr Zelenko at this link.
We will provide in the coming weeks additional coverage, including hopefully some interviews, about Ivermerctin-based therapies for COVID-19.
In the mean time, here are discussion groups you may want to join:
If you are a medical professional:
https://www.facebook.com/groups/3595465843801899/
If not, here is a more general group:
https://www.facebook.com/groups/535921330632877/
Also, you may want to join our own new discussion group, still in development, outside social media.
I wouldn’t trust that the weight dosage for humans would be the same as animals. Dogs can take up to 1mg of Benadryl per pound of weight. For me that would be 130 mg and that would kill a person. The math would tell you how to convert it to a human dosage. Animal’s bodies metabolize some meds differently than humans.
https://www.wsj.com/articles/the-treatment-that-could-crush-covid-11597360709?mod=hp_opin_pos_3
Probably paywalled article.
The WSJ opinion article doesn't mention how they are produced, their potential cost, etc.
I’ve already made arrangements with my cattle ranching buddy. He has a good supply and I told him if I get sick I’m coming to see him.
Again, missing my point.
How many mcg’s of Ivermectin would it take to equal 3 mg?
Simple question.
I honestly don’t need to know, as I am not interested in taking, although we have storage shelves full of the (gram dose) stuff :-)
Not sure I trust any recommendation from (now lefty outlet) WSJ.
If you can get past the paywall, why not copy and paste the main point/suggestion of the article, here?
TIA.
I did too. But I did NOT try it when I actually contracted Covid. The symptoms seemed mild at the time I made that decision. When I felt much worse, I figured it was probably too late, and my medical advisor said it was not a good idea at the time in case I needed hospitalization, the ivermectin would just complicate things at that point.
That said, knowing how bad I got sick, I would take some at the first signs of symptoms.
I can by Ivermectin paste wormer over the counter for my horses. Have done so for 30+ years.
Where do you put the paste when treating the horse?
Ssshhhhhh!
It may work even better than HCQ and it has not been destroyed by the media's demonization like HCQ
Nor is impacted by the profoundly destructive drug polices and restrictions implemented in the Hydroxychloroquine with hunt.
If things pan out correctly, we have an effective prevention and treatment protocol for Covid - 19.
Of course we already have had that protocol since the very start Wuhan virus outbreak, which is a tragedy for those whose lives have been unnecessarily lost and the many more who have survived with permanent damage. Not to mention the family members and the rest of society that has been devastated by draconian policies based solely on false predictions of what might happen but never did.
Fun fact from Dr Atlas, one of President Trumps new pandemic advisers - there are around 20 documented deaths attributable to hydroxycholoroquine over the last 15-20 years despite it's wide spread, long term user eating lupus and arthritis patients so it is a pretty safe .
Contrast that with the 5000 deaths per year from Tylenol overdose, not to mention the serious permanent organ system damage cased by over use or misuse of Tylenol drugs.
Folks, we have been had by lying media propagandists and profoundly destructive political leadership decisions, primarily by Democrats in deep blue states and cities.
The damage done to our country, economically and personally, has been staggering, a fact that the media has maliciously covered up and hidden from the American people.
It's just that simple
It is ineffective and in fact dangerous because it hurts the narrative of continued lockdowns and the need for a vaccine.
Because of science!
And like I said, I don’t know. I’m sure there is a formula if a person wants to take it. I don’t. I was just providing an alternative for those that might.
Paul Marik, MD of the East Virginia Medical School on August 1, without explanation, changed his COVID 19 Management Protocol -- they removed Hydroxychloroquine and substituted Ivermectin. He did provide this statement with a lot of citations (which I removed):
Symptomatic patients (at home):
• Not recommended: Hydroxychloroquine (HCQ). The use of HCQ is extremely controversial. The best scientific evidence to date suggest that HCQ has no proven benefit for post exposure prophylaxis, for the early symptomatic phase and in hospitalized patients. It should be noted that these studies did not include Zinc, and it is possible that the efficacy of HCQ requires the co-administration of Zinc. However, considering the unique pharmacokinetics of HCQ, it is unlikely that HCQ is of benefit (takes about 10 days to achieve adequate plasma and lung concentrations). The benefit derived from the co-administration of Zinc may be due to the effects of zinc alone. This is however, a very “volatile” situation, so stay tuned.
Here is the revised approach to treatment through the stages of the disease:
Another medical school (somewhere in SE Asia - maybe Singapore or Indonesia) also recently switched from HCQ to Ivermectin in their recommended treatment.
Excellent post.
And, welcome to FR!
My question is....and, my apologies if I’ve missed it in your italicized excerpt....is this a drug that causes the MSCs to activate? How do the MSCs eliminate the virus? What causes them to do that?
TIA.
“Here is their propaganda on the matter:
sure sounds like another HCQ type bashing to me.”
I agree, humans should NEVER use it, as it’s not certified for humans. Now, with that out of the way, there has already been quite a bit of use of the horse version, all with good results. They note that they have to be careful with calculating the dosage, as most humans, at least in the middle income and up areas, weigh quite a bit less than a horse.
But again, humans should NEVER use it.
“I wouldn’t trust that the weight dosage for humans would be the same as animals. Dogs can take up to 1mg of Benadryl per pound of weight. For me that would be 130 mg and that would kill a person. The math would tell you how to convert it to a human dosage. Animal’s bodies metabolize some meds differently than humans.”
I agree to not use an animal dosage schedule on humans, but the nice thing about Ivermectin is that humans already use it (an estimated 1 billion people world wide), so there’s plenty already known about what is at least a safe dosage for humans. What’s not known as well is what is the effective dosage for humans, in other words, how much must one take for it to work.
There you go being all practical and logical about things.
FDA is like, you can’t use that on your right index finger! It has only been tested for the LEFT index finger.
I’m sure that at some point when people all hear that it’s effective somebody will calculate the effective dosage. I looked it up the animal dose and 1000mcg is 1mg so a 3mg human dose would be 3000mcg animal dose. The dose for the tabs for a 55-100 pound dog is 272mcg according to the box. I’m not a math whiz so it would be dangerous for me to advise how much to take. :-) I bet somebody figures it out soon though.
Ivermectin has been around forever. It’s used to worm horses and puppies. A lot of breeders DIY puppy wormings. Ivermectin works on heart worm. You just have to get the dose exactly right.
My round about way of saying that Ivermectin is another drug, like HCQ that has been around for a thousand years and more than proven its utility.
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