Posted on 06/16/2020 12:33:05 PM PDT by ConservativeMind
There has been considerable interest in fisetin recently, especially for its potential as a senolytic, which clears away dysfunctional senescent cells that accumulate with aging. Researchers believe that fisetin may be useful in increasing the healthy period of life known as healthspan.
What is Fisetin?
Fisetin is a part of the flavonoid family of polyphenols. Fisetin acts as a pigment and influences the color of various fruits and vegetables.
Senescent cells and senolytics
As we grow older, we accumulate more and more damaged cells which cease dividing and enter a state known as senescence. Once they enter this state, they begin to secrete a cocktail of inflammatory signals known as cytokines, which summon the immune system to remove them.
When we are young, this system works perfectly, and the damaged cells are promptly removed; however, as we grow older, our immune systems slow down and senescent cell clearance begins to falter. Eventually, clearance slows down to the point that senescent cells begin to build up in the tissues contributing to the chronic inflammation known as inflammaging, harming nearby healthy cells and making them also senescent, preventing tissue repair, and facilitating the development of various age-related diseases.
It was proposed that finding ways to help the body clear away senescent cells may be the key to delaying or preventing various age-related diseases, and indeed in 2011, that idea was put to the test and seemed to bear fruit. Jan van Deursen and his team at Mayo Clinic engineered a mouse that was able to destroy its senescent cells when given a certain chemical.
Fisetin appears to be a senolytic
A number of plant flavonoids, such as quercetin, apigenin, luteolin, and curcumin, have been examined recently for their senolytic activity, and fisetin is the latest of these to enter the spotlight.
(Excerpt) Read more at lifespan.io ...
Fisetin appears to be one, but intermittent fasting is another.
Another report on fisetin...
Fisetin: A Dietary Antioxidant for Health Promotion:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3689181/
Thanks for posting this. It’s an interesting read. Don’t think I’ll run out and get supplements, but I’ll stick to my OMAD fast and keep right on loving me some onions and apples.
I’ve been intermittent fasting for a couple years. If it’s not between 6:00 pm and 10:00 pm then I’m not eating. It’s great.
It also purges out old currency from the wallet.
lol
Lotus root is right up there. Delicious. I am thinking of eating more seaweed, like in Korean seaweed soup, to ensure I have enough iodine (see article about 3 down). This would be a great side dish for it.
At least it's proven science (Yoshinori Ohsumi's Nobel in Science for autophagy, that is).
I’ve been intermittent fasting for a many years. If it’s not between 8:00 AM and 10:00 PM then I’m not eating. It’s great.
My Hunny and I are firm believers in IF, as I’m stuck in a wheelchair for the duration and it’s hard to burn calories. IF also stimulates autophagy, where your body eats up scar tissue, moles etc. Pretty fascinating for us “modern” humans, but fasting has been in practice since biblical times; even before.
Fisting? Feinstein?
“What is Fisetin?
Fisetin is a part of the flavonoid family of polyphenols.”
Perfectly clear!
"Scientists say we're soon going to be able to live until we are 200. Hell, there's not much left to do after 150." :-)
We take tumeric everyday.
Bkmrk
From wikipedia:
*********************************************************
Fisetin can be found in a wide variety of plants. It is found in Eudicotyledons, such as trees and shrubs in the family Fabaceae, such as the acacias Acacia greggii and Acacia berlandieri,the parrot tree (Butea frondosa), the honey locust (Gleditsia triacanthos), members of the family Anacardiaceae such as the Quebracho colorado and species of the genus Rhus, which contains the sumacs.
Along with myricetin, fisetin provides the color of the traditional yellow dye young fustic, which was extracted from the Eurasian smoketree (Rhus cotinus).
Many fruits and vegetables also contain fisetin, including strawberries, apples, persimmons, cucumbers and grapes. Fisetin can be extracted from fruit and herbal sources in juices, wines, and infusions such as teas. It is also found in Monocotyledons such as onions. It is also present in Pinophyta species such as the yellow cypress (Callitropsis nootkatensis).
********************************************************
I’m all in on eating strawberries and apples, persimmons and drinking wine. I like onions on my salad and burgers, sammiches, etc.
“Perfectly clear!”
It’s as plain as the ass on a goat.
How does it compare to a brisket sandwich, fries, red beans, peach cobbler for desert. Oh, two glasses of sweet tea ?
Ha! You’ve nothing to contribute other than pretending your ignorance is funny. It’s funny!
Could’ve been worse. He could have commented on “low hanging fruit”...
Disclaimer: Opinions posted on Free Republic are those of the individual posters and do not necessarily represent the opinion of Free Republic or its management. All materials posted herein are protected by copyright law and the exemption for fair use of copyrighted works.