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A Small Trial Finds That Hydroxychloroquine Is Not Effective For Treating Coronavirus
American Council on Science and Health ^ | 04/06/20 | Katherine Seley-Radtke

Posted on 04/13/2020 3:21:05 PM PDT by Pining_4_TX

On Saturday the Food and Drug Administration approved the use of two antimalarial drugs, hydroxychloroquine and a related medication, chloroquine, for emergency use to treat COVID-19. The drugs were touted by President Trump as a “game changer” for COVID-19.

However, a study just published in a French medical journal provides new evidence that hydroxychloroquine does not appear to help the immune system clear the coronavirus from the body. The study comes on the heels of two others - one in France and one in China - that reported some benefits in the combination of hydroxychloroquine and azithromycin for COVID-19 patients who didn’t have severe symptoms of the virus.

I am a medicinal chemist who has specialized in discovery and development of antiviral drugs for the past 30 years, and I have been actively working on coronaviruses for the past seven. I am among a number of researchers who are concerned that this drug has been given too much of a high priority before there is enough evidence to show it is indeed effective.

There are already other clinical studies that showed it is not effective against COVID-19 as well as several other viruses. And, more importantly, it can have dangerous side effects, as well as giving people false hope. The latter has led to widespread shortages of hydroxychloroquine for patients who need it to treat malaria, lupus and rheumatoid arthritis, the indications for which it was originally approved.

(Excerpt) Read more at acsh.org ...


TOPICS: Health/Medicine; Science
KEYWORDS: china; coronavirus; hydroxychloroquine; keyboarddoctors
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This is disappointing if it turns out to be the case. More studies are needed.

This site is not a liberal lefty site, so they are not reporting this to attack the president.

1 posted on 04/13/2020 3:21:05 PM PDT by Pining_4_TX
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To: Pining_4_TX

Tell Boris Johnson to report back to ICU.


2 posted on 04/13/2020 3:23:01 PM PDT by Vigilanteman (The politicized state destroys aspects of civil society, human kindness and private charity.)
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To: Pining_4_TX

Does not erase the numerous positive results. We already know it only works in some cases.


3 posted on 04/13/2020 3:24:20 PM PDT by gibsonguy
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To: Pining_4_TX

Small study is right! Geesh 11 patients? And where’s the ZINC????


4 posted on 04/13/2020 3:24:40 PM PDT by R.I.chopper
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To: Vigilanteman

Hey, I’m not saying this. I’m only posting it for info. If it works, that’s great. I hope it does.


5 posted on 04/13/2020 3:24:51 PM PDT by Pining_4_TX (The Nazis were socialists, and all socialists turn into Nazis.)
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To: Pining_4_TX
Professor Didier Raoult Releases the Results of a New Hydroxychloroquine Treatment Study on 1061 Patients
CovidExit.com ^ | 04/10/2020
Posted on 4/11/2020, 2:05:33 AM by SeekAndFind

The new study, of which the abstract was released today, was performed at IHU Méditerranée Infection, Marseille, France. A cohort of 1061 COVID-19 patients, treated for at least 3 days with the Hydroxychloroquine-Azithromycin (HCQ-AZ) combination and a follow-up of at least 9 days was investigated.

Key findings are:

No cardiac toxicity was observed.
A good clinical outcome and virological cure was obtained in 973 patients within 10 days (91.7%).
A poor outcome was observed for 46 patients (4.3%); 10 were transferred to intensive care units, 5 patients died (0.47%) (74-95 years old) and 31 required 10 days of hospitalization or more.

The authors conclude that:

“The HCQ-AZ combination, when started immediately after diagnosis, is a safe and efficient treatment for COVID-19, with a mortality rate of 0.5%, in elderly patients. It avoids worsening and clears virus persistence and contagiosity in most cases.”

http://www.freerepublic.com/focus/chat/3833916/posts?page=1

6 posted on 04/13/2020 3:25:52 PM PDT by SmokingJoe
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To: Pining_4_TX

...new evidence that hydroxychloroquine does not appear to help the immune system clear the coronavirus from the body.

HCQ is *not* intended as a virus killer. The purpose is to reduce the ability of the Corona virus to replicate in the patient.


7 posted on 04/13/2020 3:26:00 PM PDT by Flick Lives (A liberal is someone who worries that somewhere, someone is enjoying life.)
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To: Pining_4_TX

a full sized clinical trial was just published in France...
over 1000 participant patients.
91.7 percent successful recovery rate in just 3 days
of these cheap and plentiful little pills

to my way of reckoning, that’s no failure


8 posted on 04/13/2020 3:26:02 PM PDT by faithhopecharity ("Politicians are not born, they are excreted." Marcus Tullius Cicero (106 to 43 BCE))
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To: Pining_4_TX

Never believe females with hyphenated names. ;-)


9 posted on 04/13/2020 3:27:57 PM PDT by Rightwing Conspiratr1
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To: Pining_4_TX

I pretty much expected this from the trials. Thousands of doctors, and multiple country’s are all wrong about what they have found with using HCQ. The Trial is rigged. Trials are rigged all the time.


10 posted on 04/13/2020 3:28:00 PM PDT by Revel
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To: Pining_4_TX
However, a study just published in a French medical journal provides new evidence that hydroxychloroquine does not appear to help the immune system clear the coronavirus from the body.

Does sound disappointing. From an old Lancet article (2003):

"Chloroquine exerts direct antiviral effects, inhibiting pH-dependent steps of the replication of several viruses including members of the flaviviruses, retroviruses, and coronaviruses."

But this was long before the COVID-19 coronavirus emerged. More studies will need to be done - there's been anecdotal evidence, and given how suddenly this virus has emerged, there hasn't been enough time for thorough trials.
11 posted on 04/13/2020 3:28:23 PM PDT by AnotherUnixGeek
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To: Pining_4_TX

No zinc?


12 posted on 04/13/2020 3:29:26 PM PDT by a fool in paradise (Everyone knows Hillary was corrupt, lied, destroyed documents, and influenced witnesses. Rat crime.)
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To: R.I.chopper

yep


13 posted on 04/13/2020 3:29:51 PM PDT by a fool in paradise (Everyone knows Hillary was corrupt, lied, destroyed documents, and influenced witnesses. Rat crime.)
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To: Pining_4_TX

What is the point of all these “trials” coming out of the woodwork? Some work would be good to see who it might hurt.

Shouldn’t all of the rest of these folks be working on developing superior alternatives and then testing those?


14 posted on 04/13/2020 3:30:05 PM PDT by Paladin2
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To: Pining_4_TX

She appears to have conflicts.

Medical writers should never have them or should disclose if any appearance of conflict. According to comments on article a little skepticism seems appropriate.


15 posted on 04/13/2020 3:30:23 PM PDT by amihow
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To: Pining_4_TX

well, it is wrong.


16 posted on 04/13/2020 3:31:04 PM PDT by yldstrk (Bingo! We have a winner!)
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To: Pining_4_TX

She was already in a posted article a few weeks ago pooping on HCQ. Look at her hyphenated name. She probably has a RESIST bumper sticker on her Prius.


17 posted on 04/13/2020 3:32:05 PM PDT by willk (A bias news media is not a free press.)
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To: Pining_4_TX

So those with concerns about HCQS should refuse to allow it to used in their treatment if the contract the illness.


18 posted on 04/13/2020 3:32:45 PM PDT by rktman ( #My2ndAmend! ----- Enlisted in the Navy in '67 to protect folks rights to strip my rights. WTH?)
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To: Pining_4_TX
Here's the author, Dr. Karen Katherine, from that world-class center of clinical trials, the University of Maryland Baltimore County:

it's funny, but this is a small, non-peer-reviewed study, without Zinc as recommened by the studies which showed positive effects.

I wonder how many boxes of Donuts Nancy Pelosi and Bill Gates promised her...

19 posted on 04/13/2020 3:33:31 PM PDT by grey_whiskers (The opinions are solely those of the author and are subject to change with out notice.)
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To: Pining_4_TX

And when they say a “small” study, they mean 11 people. From the actual medial study...

“There were 7 men and 4 women with a mean age of 58.7 years (range: 20-77), 8 had significant comorbidities associated with poor outcomes (obesity: 2; solid cancer: 3; hematological cancer: 2; HIV-infection: 1).”


20 posted on 04/13/2020 3:35:00 PM PDT by Flick Lives (A liberal is someone who worries that somewhere, someone is enjoying life.)
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