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Corona Virus Daily Thread #43

Posted on 04/10/2020 10:52:27 AM PDT by LilFarmer

Previous thread here: http://freerepublic.com/focus/f-chat/3833419/posts


TOPICS: Health/Medicine
KEYWORDS: chinaflu; coronavirus; livethread; wuhan
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To: central_va

You’re trying to completely rewire the American economy. It will cause more turmoil than the slowdown and restart. And what a great way to give the progressive mafia a chance to monkey with our system.


361 posted on 04/11/2020 3:41:43 PM PDT by calenel (Don't panic. Prepare and be vigilant. Join the war effort. On the human side.)
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To: LilFarmer
And think the millennials and Gen Z are pissed now? Wait until they wake up in a few years with oral thrush, chronic sore throats and other immune system failing symptoms.

They'll remember, they were told, "jump in, water's fine, it has no effect on you"

362 posted on 04/11/2020 3:46:29 PM PDT by riri (If people still dropping, most aint shopping.)
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To: riri

Wait till they’re told they’ll never reproduce the species. And their T is that of an old man. When they’re 35.


363 posted on 04/11/2020 3:47:59 PM PDT by Black Agnes
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To: Tolerance Sucks Rocks

3 different links here
Is the corona virus a bio-weapon?
THIS IS A MUST READ!
https://teletype.in/@adrianbond/Bg361tQU

Was it a bioweapon?
@StefanMolyneux interviews Dr Paul Cottrell
https://www.youtube.com/watch?v=J6VEYzwSdZU

1st documentary movie on the origin of CCP virus, Tracking Down the Origin of the Wuhan Coronavirus
https://youtu.be/Gdd7dtDaYmM


364 posted on 04/11/2020 3:49:29 PM PDT by RaceBannon (Rom 5:8 But God commendeth his love toward us, in that, while we were yet sinners, Christ died for)
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To: LilFarmer
He's got it part right and part wrong.

This might be the fog of war, though, on all sides.

Recall that the article he's commenting on was non-peer-reviewed.

Cliff's Notes TO the Cliff's Notes:

Yes, the paper he critiques only uses molecular modeling; it's not even "in vitro" (in glass, that is, in labratory tests) let alone in vivo (in real animals or patients)

Yes, he's right about the structure of the hemoglobin.

He appears to be mischaracterizing the paper he attacks, on what it claims: I don't think they claim the entire virus tries to get into the active site of the hemoglobin, only that certain proteins *produced by the virus* hitch a ride on the porphyrin, get shuttled into non-infected cells, and the screw up the binding site. (See Section 3.2 of the paper he is criticizing.)

Also, he seems to be anxious to mischaracterize things, e.g. his characterizing of the call for blood transfusions as "throwing more logs on the fire and saying the fire is going out because they're not burning yet"

If the blood cells *do* happen to be damaged so they are not carrying enough O2, then one reasonable treatment might be to add new blood cells, IF it can be assured the new blood cells don't get chewed up in turn.

He is correct -- at least according to the conclusions of the MedCram YouTube videos, on saturation vs. partial pressure of O2 : but it seems to me to still be unclear, from other doctors (e.g. the guy in Italy who calls Wuhan Flu as "high altitude sickness") whether it is the amount of O2 making it into the blood, or how full red blood cells are of O2; or if those two things happen in differing amounts at different stages of infection.

(One of the effective treatments seems to be ECMO (extracorporeal membrane oxygenation) which is taking the blood out of the body, oxygenating it externally, and sending it back in. In favor of this MD's arguments, this would be more efficacious if it were actual damage to the alveoli or inflammation/mucus preventing gaseous exchange, and less effective if it were the red blood cells themselves were damaged.)

An example of fog of war is the following. This MD says :

Blog post says: Patients desaturate as their hemoglobin loses iron Reality: Even if the virus were to eject the iron from hemoglobin (which it almost certainly does not), it would not likely result in a measurable desaturation. Saturation is most commonly measured via pulse oximetry (pulseox), which uses light to differentiate Hb with oxygen from Hb without oxygen. Both these forms of Hb, however, have the iron present, and most clinical pulse oximeters only work when these two forms — and only these two forms — of Hb are present [3]. A novel form of Hb with the virus in place of the iron would absorb light very differently from either of these forms, and such a protein (if it could exist) would almost certainly result in incomprehensible pulseox readings, not a desaturation.

Here he seems to be talking through his hat "I'm a doctor, I know everything."

Let's say for the sake of argument, that there is loss of heme -- not total, but partial -- in some of the red blood cells.

Then the characteristic absorption spectrum for those red blood cells -- that is, the curve showing what percentage of light is absorbed for each frequency-- would differ from normal blood cells. The normal pulseox uses red (640 nm) and infrared (940 nm) to differentiate between oxygenated and deoxygenated blood cells. But if you have blood cells, where the heme has been damaged, then they wouldn't necessarily give a nonsensical number: because some amount of the heme in those blood cells, having a different absorption spectrum, would simply fail to show up, either as oxygenated or deoxygenated. So the ratio of oxygenated to deoxygenated wouldn't *necessarily* change -- since the damaged hemes wouldn't be contributing to the signal at either wavelength; the only thing which would differ would be the absolute values of the numbers.

At another point the MD says:

There is a letter out of Northern Italy suggesting that ARDS arising from Covid-19 may not require or could even be harmed by high-pressure mechanical ventilation [7], but this same letter suggests that intubation and mechanical ventilation without high pressures should be prioritized for patients who are struggling to breathe, not avoided as suggested in the blog post.

But the article he is attacking says:

But if they’re conscious, alert, compliant — keep them on O2. Max it if you have to. If you HAVE to inevitably ventilate, do it at low pressure but max O2. Don’t tear up their lungs with max PEEP, you’re doing more harm to the patient because you’re treating the wrong disease.

Which is exactly the same thing That might be "harumph, it's not a REAL doctor. I'll put them in their place." That might be "they made, one, two, mistakes, I've lost patience and I'm going to trash everything they wrote as hard as I can."

What is suspicious is that he's using the attack on that article, to throw doubt on the HCQ; assuming that the mechanism by which HCQ helps with malaria, is of necessity the same by which it helps with Wuhan Flu.

In particular, it has been alleged by other people that the HCQ is an ionophore, which acts as portal to get zinc into the cell, and it is then the zinc which interferes with viral reproduction: this is not what this guy characterizes the HCQ as doing.

365 posted on 04/11/2020 3:51:24 PM PDT by grey_whiskers (The opinions are solely those of the author and are subject to change with out notice.)
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To: FreedomForce
Not an MD. Reading the treatment, the packed RBC and hydroxychloroquine replaced RBCs with COVID-19 damaged hemoglobin and protected the replacement cells. The lymphocytes were very low compared to neutrophils. In other articles, when the neutrophil / lympocyte ratio hits 20:1, the patient is in serious trouble. Overall, a good recovery. Not certain exactly how the rhEPO contributed.
366 posted on 04/11/2020 3:51:39 PM PDT by Myrddin
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To: amorphous

This initial release, assuming bioweapon, had to be accidental. Why on earth do what they did to Wuhan ? It they intended to release a bioweapon why not in the US near a US Bio Research facility ?

We got good data from China for about 2 to 3 weeks. First complete genome and everything. Then it all changed and research and data release was shutdown. At that point they decided to game the deck of cards they had. So now we are in a biowarfare scenario until the Chinese come clean.


367 posted on 04/11/2020 3:53:08 PM PDT by justa-hairyape (The user name is sarcastic. Although at times it may not appear that way.)
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To: justa-hairyape

I recall reading somewhere that Wuhan was the capital of Chiang Kai Shek’s government for a while.

Also Chongqing.

Seems those two cities/provinces were hit the hardest.

Makes you wonder.


368 posted on 04/11/2020 3:56:59 PM PDT by Black Agnes
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To: All

I hadn’t looked at the stats for a bit, but checking them today, the DP data has dropped off the radar. Last known numbers were 13 of 712 cases dead and about 80 still unresolved.

SK has crossed the 2% DCR with about 1/3 of their cases unresolved. They are finding double digit numbers of cases, still, but it seems to be dwindling steadily. Fatalities are occurring at a higher relative rate than new cases, so that 2% isn’t going to decrease. 2% seems to be the best case for a large infection so far.


369 posted on 04/11/2020 4:09:28 PM PDT by calenel (Don't panic. Prepare and be vigilant. Join the war effort. On the human side.)
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This is getting insane, I had to drive into B-more because a friend staying with us has to tend to her cat 🐱 folks were walking outside with masks!! - why outside? Thank goodness I'm still working so I can get away from this insanity...
370 posted on 04/11/2020 4:16:00 PM PDT by dakine
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To: Black Agnes; riri

Or they end up with destroyed lungs or kidneys...


371 posted on 04/11/2020 4:25:01 PM PDT by LilFarmer ("Everything we do before a pandemic will seem alarmist. Everything we do after will seem inadequate")
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To: LilFarmer; riri

Novel virus.

No good answers.


372 posted on 04/11/2020 4:31:31 PM PDT by Black Agnes
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To: chris37
All I can say about it is that it really scary. I hope and pray this does not happen at all. Stupid virus!

My feelings as well Chris. 3% doesn't sound like much, until you realize that's 3% per day, compounded daily. Then you begin to understand why the numbers increase so rapidly. And I think that's about the best we can hope for without a cure or vaccine. That's about were Korea and Italy are at now.

Since Korea's total number of fatalities are low, unlike say Italy, their daily death rate isn't that great, but it will continue to climb until the virus runs out of hosts, herd immunity is reached, or a vaccine/cure is found. :(

Your input/commments/questions are always appreciates sir! Btw, I'm quite sure there's probably a big bass hiding under yonder bank in the deep part of that creek you often visit. :)

373 posted on 04/11/2020 4:36:46 PM PDT by amorphous
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To: amorphous

WEll, “the barrier” is a product the R0 we can do, and the IFR we can do.

Now we van affect the R0 but soon we will have to affect the IFR... or the deaths will indeed hit a barrier.
I don’t think we’ll do much more reduction in the R0- maybe some marginal reduction.

So.
Keep up the “social distancing” for now, but that’s only a temporary factor- the only one we could do at the time.
Medicine will have to solve the medical problems with the virus.
Not necessarily a vaccine- effective treatment would make a huge, and probably earlier, difference.


374 posted on 04/11/2020 4:43:00 PM PDT by mrsmith (Dumb sluts (M / F) : Lifeblood of the Media, Backbone of the Democrat/RINO Party!)
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To: firebrand

Could part of this be that the personnel in the nursing homes are not the same in training as the personnel in a hospital? Professionals who have learned how to avoid infections are undoubtedly more adept at keep things from spreading. Not saying this IS the reason, but maybe it contributes.
**********************************************************************************
I can’t speak to the training, however I can speak to the actual practice I have observed in the nursing homes that my Mom was in at various times.

In general the actual sanitation practices are much less than in a hospital. Of course there are also differences in practices in the hospital. The general practices are not as good as those followed in the ICU, and the ICU is not as good as that followed in the recovery area for people coming out of open heart surgery-for example.

Nursing homes will need to improve their standard procedures to avoid Corona Chan transmissions.


375 posted on 04/11/2020 4:44:11 PM PDT by greeneyes ( Moderation In Pursuit of Justice is NO Virtue--LET FREEDOM RING)
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To: LilFarmer

Images well-sized on my desktop.


376 posted on 04/11/2020 4:45:44 PM PDT by mrsmith (Dumb sluts (M / F) : Lifeblood of the Media, Backbone of the Democrat/RINO Party!)
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To: Fury

I’ve been telling folks for a while that coronaviruses have a sketchy record of conferring long term immunity, and that betting major public health policies on “herd immunity” or a non-existent vaccine is a gamble that we could lose. We really need this bug to produce at least 2 years of immunity, but I can’t begin to put odds on the likelihood of that. We just don’t know.

If there is no immunity, maybe this is the catalyst to finally get people to take their diet, health and fitness more seriously. It’s just so much easier to get a vaccine and stuff ourselves with carbs...


377 posted on 04/11/2020 4:54:00 PM PDT by ETCM
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To: amorphous

Several times when I’ve been at the river, I’ll see a gentleman or two come wading up the middle of it with their fishing pole fishing the deep holes.

They usually have an innertube with them carrying an ice chest or two. for the whole day. There’s just so many great ways to spend time here, none of them really cost anything. Just a matter of how much do you love to be in ice cold, refreshing water under the bluest of skies, and when the sun shines down on the water, you can see just how clear and beautiful it is.


378 posted on 04/11/2020 4:55:45 PM PDT by chris37 (Coronavirus wasn't born in a bowl of bat soup.)
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To: justa-hairyape
Why on earth do what they did to Wuhan ?

I can think of several reasons, assuming it wasn't an accidental release - and I'm not saying it wasn't:

1. To inoculate their population against this novel corona virus by first releasing a less lethal strain among their own people.

2. To hide an intentional act of aggression by using their own people as a smoke screen. And once the virus is spreading throughout the world, use the spread as a smoke screen to release a more lethal strain within your enemy's border.

3. To make use lockdowns among their own people for bringing protestors, foreign agents, and dissenters under control. And to ready the general population for war.

4. To thin their heard, by eliminating those burdensome to their goal of world domination.

379 posted on 04/11/2020 4:56:31 PM PDT by amorphous
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To: amorphous

I should point out that the purpose of social distancing is to flatten the peak so the system isn’t overloaded which would drive up the IFR.
It’s accomplished that.
Hurray!

But it’s not the only game in town.


380 posted on 04/11/2020 4:58:17 PM PDT by mrsmith (Dumb sluts (M / F) : Lifeblood of the Media, Backbone of the Democrat/RINO Party!)
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