Posted on 04/04/2020 6:43:27 AM PDT by Hostage
From commentary by Steven Mehl:
Hydroxychloroquine's mechanism of action appears to be how it acts as a strong zinc ionophore (i.e. pushing extra zinc into the intracellular space) and allowing that zinc to inhibit the enzyme that the virus is using to replicate. Two other zinc ionophores that are over the counter are Quercetin (flavonol) and EGCG (found in high concentrations in "matcha" green tea) and also available as a supplement.
Here is Dr. Zelenko's 'Zev' treatment regimen:
Patients treated with three drug regimen:
CONCLUSION - TREAT AS EARLY AND AS AGGRESSIVELY AS POSSIBLE IN THE OUTPATIENT SETTING
“But the virus (unlike Malaria parasites) uses DNA enzymes to replicate (multiply) so the cytokine response inadvertently ends up flushing more and more virus out where it spreads and spreads and spreads making matters much worse.”
Why do you say “inadvertently”? Isn’t that what it’s supposed to do?
And what is the role of HCQ in all this?
HCQ latches onto the cell receptor to open up a channel for the Zinc to flow through. It enables the cell to take up more Zinc. Without HCQ, the Zinc is not going to be at levels where it is effective.
> “Why do you say “inadvertently”? Isn’t that what it’s supposed to do?”
It is doing what it’s supposed to do but in a twisted purpose it becomes not a virus flush but a virus pump.
If the virus wasn’t able to use the cell’s DNA to replicate, the cytokine immune response would do the job it was created to do which is to flush out the virus which would then be eliminated in the urine.
But the virus keeps growing, the cytokine response keeps flushing and flushing in effect becoming a pump for the virus and helping the virus spread.
FYI, I am not the seller and I have no connection to the seller. 200 mg bark, 1 zine tab, vitamin D and vitamin C. Hope it works.
Do you have any idea how much EGCG instead of hydroxychloroquine one should take daily to treat coronavirus (when one already has symptoms)? I doubt that in my country I will have access to hydroxychloroquine.
So the main purpose of HCQ is to facilitate absorption of zinc by the cell and not suppress the immune system? Or is the immune system kept in check by zinc in the cell keeping the virus from replicating and thus not needing as strong an immune response?
In other words, getting zinc in the cell is the silver bullet? But yet, HCQ is used as an immunosuppressant in autoimmune diseases such as lupus, so it must play a similar role here too, right?
“But the virus keeps growing, the cytokine response keeps flushing and flushing in effect becoming a pump for the virus and helping the virus spread.”
I don’t get that. Seems contradictory, unless you mean that the viruses are reproducing so fast that the immune system can’t keep up.
Azithromycin has an anti-viral activity although the mechanism of action is not fully defined. Zika infection in cell culture testing was reduced by 95%. The medication has an affinity for neural tissues, and is approved as safe and effective for treatment when carrying a pregnancy.
https://aac.asm.org/content/61/9/e01152-17
There is no amount of EGCG known that can reverse symptoms once infected.
It is believed that it can be used as a prophylactic meaning prep the body to suppress the effects of infection, make the body better prepared, stronger in case the virus comes in contact.
It is used more in a time of ‘health as a habit’ like drinking juices high in Vit C or echinacea tea before and during flu season.
As a prophylactic it’s not guaranteed but a generally good idea and is effective in many cases.
I think if you do some digging, you can find out how to make your own hydroxychloroquine, but beware, you will need to study dosages and other things to be safe with it.
There are other homeopathic products that are known to be effective before too long into the infection:
1 Osha Root Tincture (Rocky Mountain herb used by Native Americans to treat respiratory infections, treat colds, symptoms of viral infections, it kicks out viral infections before they become full-blown; take as soon as symptoms appear, provides immediate relief; takes many years to grow but is a root of the same family as celery, carrots, parseley)
2 Occillococcinum (made from heart & liver of duck, diluted until essentially no molecules of heart or liver are found in actual pill. Wildfowl are natural reservoirs for influenza, nucleic/phosphoric compounds in the pill resemble influenza, contribute to antiviral activity, looks like virus, creates response but no sickness)
3 Colloidal Silver (use distilled water, silver rods, voltage source with electric clips; plenty of DIY methods, the silver ions clean the body of nasty things, takes out the garbage so to speak, long-long history going back to classical Greek physicians)
Many of the above things are available on Amazon although inventory is up and down; need to check frequently.
Try Oysters as the most potent source of zinc, other shellfish to a lesser degree.
Quercetin affects drug activity which may need transformation by the liver to an active form, and removal from circulation by the liver in other cases. The extract of green tea EGCG may be a more effective ionophore.
> “main purpose of HCQ is to facilitate absorption of zinc by the cell”
Yes, in this case of SARS-COV-2, but it also works on the outside to prevent viruses from entering cells by blocking channels and receptors that viruses use to enter the cell.
A pedestrian sort of example or lock and key analogy is when HCQ is acting as a lock to the cell door, the SARS-COV-2 does not have the right key to open the HCQ lock but Zinc does, Zinc has the correct key to get in.
However, if the virus got in before the HCQ lock was in place, then Zinc will go in and prevent the virus from growing and causing damage, the immune response will kick the virus out and it can’t go back in because the HCQ lock prevents it.
> “immune system kept in check by zinc in the cell keeping the virus from replicating and thus not needing as strong an immune response”
Yes, that’s the understanding.
> “HCQ is used as an immunosuppressant in autoimmune diseases such as lupus”
Not sure, but HCQ as mentioned above is also used outside the cell to block entry into the cell, limiting the immune response because a response is not needed.
> “the viruses are reproducing so fast that the immune system can’t keep up”
My take is the immune system keeps up but goes into overdrive becoming a problem in itself. The overdrive condition is caused by viral activity that does not subside.
A casual pedestrian example is I turn on the hose to wash my car, the water never shuts off and creates a flood, the Fire Department is called, the neighbors gather in curiosity, etc. Why was the hose not turned off? Something prevented it. A simple short car washing chore turns into a neighborhood spectacle. But the hose and water supply work fine otherwise, only the shutoff was kept from working properly.
It has been proven that hydroxychloroquine and chloroquine are ionophores the transport zinc into cells (theoretically the reason it works to stop the inner-cellular reproduction of the virus). I have found no scientific report that quinine alone or quinine in tonic water has a similar function. Perhaps you can point me to a study that proves that it does.
I talked to my sister-in-law a couple days ago when the governor in her state imposed a stay at home order.
I told her the good news is HCQ and Zinc were going to beat this thing and she said an MSM reporter read off the horrific side effects of hydroxychloroquine and because of this there was no way she was going to be taking HCQ.
So I read her a list of side effects from another drug where the side effects were nearly identical to HCQ.
That other drug was aspirin.
I thought she was going to hang up on me, she said she had to go do some chores.
The point is, and from my experience, that when an observation is made, be it a side effect or another possible therapeutic effect, whatever effects are observed, must be either for scientific integrity or legal liability, must be recorded. So the list grows.
And in some rare cases, one of the off-label uses, or orphan effects can be used in conjunction with something else with great success such as Zev had here with HCQ and Zinc.
Azt may have anti-viral action but its main action is antibacterial. If it were a potent antiviral drug, we would know about it and it would be in wide usage as such. Because it’s not used in that vein, we can infer there are better alternatives.
All of these drugs are ‘small’ molecules with known structure. They are like keys to locks. They are created as such.
All viruses, bacteria, pathogens are like locks, or have structures on their surfaces with ‘active pockets’ acting like locks.
We find the structural cartoons using X-Ray Crystallography. None of the cartoons are a true depiction but we try to get them as precise as possible. We settle for them being useful.
There’s a dictum in science:
“All models are FALSE, some are USEFUL”.
Einstein’s models were false in the sense they did not capture the entirety of everything. But they were and are amazingly useful.
Same with Newton’s models. He got close to truth but not quite there. He ended up concocting monumental fudge factors to make his equations work.
What distinguishes us from astrologists like economists, democrats, Gaia worshippers, Jane Fonda, etc is we admit and subscribe to:
“We know our models are not perfect, therefore we pick the ones that are most useful” (same as above science dictum)
Whereas the astrologists subscribe to:
“Our model is useful, therefore it must be true” (and they ‘feel’ it is true because it seems that way and it seems useful so therefore it’s true because it’s useful, around and around in circles ad nauseum). Then they insult us by saying “believe the science. listen to the scientists Mr. Trump” as if they and only they have a trademark on ‘science’. Yeah, their science which they deem true because they find it’s useful, when it fails, it’s the fault of the deplorables or they change the subject and refuse to hear anything that’s not on the topic they moved to.
So when we read something from CDC or NIH or Johns Hopkins (samething) or Dr. Fauci or Bill Gates & Company, or American Society of Microbiology, I am always thinking, thank you for the menu, now let’s see if there’s anything good on it and can I trust that it won’t make me sick?
Gong back to molecular models, many substances modeled into cartoons can have multiple actions or purposes, But there is a rating system that classifies what they are best for. I would bet Azt is not used as an antiviral because in the universe of molecular structures it’s only sometimes interesting in certain rare locks that no one has use for. But as an antibiotic in the same universe, it’s a rockstar. Just my take.
Add salt and lime juice. It almost makes it tolerable!
I have ordered the Soda Stream concentrate
I have not tried it yet. I wonder if you can just take it without the soda?
I didn’t say quinine alone will do the trick. I said tonic with quinine and Zinc supplements might be worth considering as a prophylactic adapted to everyday living, as a habit to guard against viruses taking root and getting out of control.
HCQ, or Plaquenil, cannot be administered willy nilly. Persons with decreased liver or kidney function are at risk for serious complications from the drug.
Perhaps I didn’t express myself well. I meant using EGCG as a zinc ionophore to transport zinc into the infected cells. The zinc then does the job and stops the virus from replicating. How much EGCG do you need for that?
It’s been a long time since I was in the Czech Republic.
If you are there, I can’t understand why HCQ would be held pack from Czech doctors prescribing it.
To answer your question, try finding a dosage equivalent table between active ingredients for HCQ and for EGCG.
I haven’t checked but there might be concentrated EGCG forms, but are they safe?
But to be smart, I would discuss with a doctor or naturopath.
Bttt
Unfortunately, the Ministry of Health of the Czech Republic has banned most doctors from prescribing hydroxychloroquine. It will be reserved for hospitals.
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