Posted on 04/01/2020 6:00:15 PM PDT by SeekAndFind
Scientists around the world have been racing to develop treatments, cures and a vaccine for COVID-19, and are getting closer by the day.
Jacob Glanville - one of the stars of Netflix documentary Pandemic - runs Distributed Bio, which has been working to find an antibody therapy.
On Monday he tweeted that a development was imminent.
"I'm happy to report that my team has successfully taken five antibodies that back in 2002 were determined to bind and neutralise, block and stop the SARS virus," Dr Glanville told Checkpoint.
"We've evolved them in our laboratory, so now they very vigorously block and stop the SARS-CoV-2 [COVID-19] virus as well.
"This makes them suitable medicines that one could use once they've gone through human testing to treat the virus," Dr Glanville said.
"The new virus is a cousin of the old SARS. So what we've done is we've created hundreds of millions of versions of those antibodies, we've mutated them a bit, and in that pool of mutated versions, we found versions that cross them over.
"So now we know they bind on the same spot as the new virus, COVID-19.
"It binds the spot that the virus uses to gain entry into your cells. It blocks that.
"At this point we know it binds the same spot extremely tightly with high affinity. The next step is we send the antibodies to the military, and they will directly put those on the virus and show that it blocks its ability to infect cells."
Dr Glanville told Checkpoint the military deals with the virus itself as he does not want COVID-19 or SARS in his laboratory.
"The other nice thing about it is you want the stamp of approval of a government military to independently test your work. This is one of the foundations of good science.
"Antibodies are attractive because you can give them to a patient right when they're in the hospital like an antiviral. You can also give them to doctors, you could give them to the elderly people to prevent them from getting sick."
There are a couple of groups around the world who have been working on developing antibodies, he said.
"Part of the reason we think we're moving pretty fast is that instead of starting from scratch discovering an antibody, we went to these existing antibodies that were already extremely well characterised against SARS. And we've adapted them. So we're piggybacking on two years of research.
"It's sort of like a short-term vaccine, except it works immediately.
"A vaccine could take six to eight weeks to take effect, where this will take effect within 20 minutes. You could give it to a patient who's sick, experiencing COVID-19, then within 20 minutes of receiving the shot, their body is flooded with those antibodies.
"Those antibodies will surround and stick all over a virus and make it so it's no longer infectious."
The disadvantage compared to a vaccine is that a vaccine might give you a year or multiple years of protection, Dr Glanville said. Antibodies will only give protection for eight to 10 weeks.
The military will test the antibodies against COVID-19 and another laboratory will start tests to make sure the medicine is safe for humans.
If those are successful, production of the antibodies have to be scaled up.
"We use very exacting manufacturing standards called GMP for making a medicine, and that can take multiple months," Dr Glanville said.
"Once that material is ready we go into a human trial. That's a... trial where you give it to a series of 400 to 600 people who are in hospitals experiencing symptoms, then you watch over the next five to 10 days to see whether it helped or not."
He said he and his colleagues are doing everything they can to speed up the process, but it does take time.
"We have saved potentially years of research by piggybacking on the SARS antibodies and our technology is very good at engineering these things to cross and we've succeeded in doing that.
"The next step, the big-time consuming part, is the GMP manufacturer. Traditionally, that takes nine to 12 months, obviously we can't wait that long. So we've worked with two different partners to try to accelerate that to take a few months but that does take time and there's really no way around."
"Assuming that we're able to complete our study, at the end of summer… and it looks good, then we would use something called compassionate use.
"This is was used in the Ebola crisis. And it's been used in other cases where if you have something that's effective and there's no other good medicine, you can begin releasing it to the world for use prior to going through all the approval process.
"That could be as early as September. Unfortunately, that's also as far away as September.
"So that's as fast as we can conceive of having this medicine widely available."
He told Checkpoint it is essential for his laboratory that everyone gains access to the medicine.
He said they are talking to the European Commission and there is interest in Asia.
"My feeling is that we should also in anticipation that that study looks good… we should start scaling up a lot more doses, hundreds of thousands to millions for the next step."
Dr. Marc Siegel actually mentioned this development at Tucker Carlson’s show tonight.
Great news!
Praying...
this guy better watch his six
lots of dems out there
Now why would the Dems want to sabotage his work?
Dems get infected with the virus too.
Antibody therapy
“It’s sort of like a short-term vaccine, except it works immediately.
“A vaccine could take six to eight weeks to take effect, where this will take effect within 20 minutes. You could give it to a patient who’s sick, experiencing COVID-19, then within 20 minutes of receiving the shot, their body is flooded with those antibodies.
“Those antibodies will surround and stick all over a virus and make it so it’s no longer infectious.”
The disadvantage compared to a vaccine is that a vaccine might give you a year or multiple years of protection, Dr Glanville said. Antibodies will only give protection for eight to 10 weeks.
TDS confers false immunity
Antibodies shouldn't be compared directly to vaccines because they do different things. So it's not fair to say one has an advantage or disadvantage over the other. Antibodies disable the enemy. They basically tie up the viruses' hands so the viruses float around harmlessly in the blood until they die or are removed by the immune system. Their use will be in therapy for those already infected.
Vaccines result in an actual immune response - as in fighting and overpowering a fully functional enemy. They are long lived, but also don't work on existing infections. Their role is to protect against future infections.
So it is more like a treatment like the anti-malarials and Z-pak....
Prayers UP for that researcher!!!!
Godspeed to him on his endeavor!!
I personally think there has been a vaccine, cure all along and the people who want to destroy US and/or President just allow our country to drag things out long enough to hit us hard financially.
Amazing how fast they can come up with a cure/vaccine for this.
"This was used in the Ebola crisis. And it's been used in other cases where if you have something that's effective and there's no other good medicine, you can begin releasing it to the world for use prior to going through all the approval process.
"That could be as early as September. Unfortunately, that's also as far away as September.
This is a very promising development.
The "approval process" must be streamlined using "compassionate use" to get these shots into arms by June--not September.
This virus will have burned completely through the American citizenry by this September.
Prayers going up!
This would work..essential snake anti venom but against the virus not a snake venom. But you could use it the same way. A patient in extremis could get the stuff instantly and like a snake bite the entire process stops. It’s just a matter of setting the dose. How much can we get and when? Here’s the thing you aren’t going to like. The first to get it will be the hospital staff that gets sick. You have to get them back on their feet fast.
Battlefield decisions in America’s hospitals.
Wasn’t there a problem with that vaccine?
Don’t forget the filthy rich celebrities and politicians who will get this treatment long before the rest of us.
Then they can go join Ahnold in that opulent jacuzzi of his and smoke stogies.
RE: Wasn’t there a problem with that vaccine?
That question is a little vague. Which vaccine are you referring to?
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