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Two generic drugs being tested in U.S. in race to find coronavirus treatments
Reuters ^ | March 19, 2020 / 6:05 AM | Deena Beasley

Posted on 03/23/2020 3:39:09 AM PDT by Zhang Fei

A French team on Tuesday said initial results from a 24-patient trial of hydroxychloroquine showed that 25% of patients given the drug still carried the coronavirus after six days, compared with 90% of patients given a placebo.

Tolar said he bought 1,500 doses of hydroxychloroquine for a “laughable” amount of money. “We don’t need a multibillion-dollar investment. It is part of the beauty of this approach,” he said.

But he and others cautioned that people should not be using any prescription drugs without medical oversight.

“These treatments should be used only in hospitals by critical care specialists,” said Dr. Russel Buhr, critical care pulmonologist at the University of California, Los Angeles.

Also this week, the University of Minnesota launched two trials testing losartan - one to measure whether the hypertension drug reduces the risk of organ failure for COVID-19 patients who have been hospitalized, and another looking at whether the drug can limit the need for hospitalizations.

Losartan is an angiotensin receptor 1 (AT1R) blocker, which researchers say could play a role in blocking an enzyme used by the virus to bind to cells.

Pharmaceutical companies are also working to develop treatments for COVID-19, including Gilead Sciences Inc’s experimental antiviral drug remdesivir, which is given to hospitalized patients via intravenous infusion over several days.

The New England Journal of Medicine earlier this month described how the drug was successfully used on the first patient infected by the novel coronavirus in the United States.

Results from a remdesivir trial in China could come early next month, while Gilead has begun two international trials of the drug that previously failed as a potential Ebola treatment. And the National Institutes of Health last month began testing it on patients in a U.S. trial.

(Excerpt) Read more at reuters.com ...


TOPICS: Health/Medicine; Local News; Science; Society
KEYWORDS: china; covid19; italy; kag; maga; moreoldnews; pandemic; sarscov2; trump
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Hydroxychloroquine, a malaria drug and losartan, a blood pressure drug.
1 posted on 03/23/2020 3:39:09 AM PDT by Zhang Fei
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To: Zhang Fei

2 posted on 03/23/2020 3:46:44 AM PDT by Bobalu (We are going to witness such a circus between now and Nov that we should have to buy tickets)
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To: Zhang Fei

One New York hospital is already using chloroquine, but it’s clear not every doctor is prescribing it, which is why Trump’s mention is a real shot in the arm for patients who can’t get tested, are being fobbed off with standard flu medications and, in some cases, dying:


https://www.wired.com/story/an-old-malaria-drug-may-fight-covid-19-and-silicon-valleys-into-it/
[Covid-19 patients are already getting it. Montefiore Medical Center in New York has already started seeing the surge of Covid-19 patients that public health experts have been warning about. The hospital is participating in the remdesivir trial and is giving Covid-19 patients chloroquine. “All of our patients get put on chloroquine, as well as on antiretrovirals. We’re using Kaletra. Different places are using different antiretrovirals,” says Liise-anne Pirofski, chief of infectious diseases at Albert Einstein College of Medicine and Montefiore. “Everybody gets that, unless they have some contraindication.”]


3 posted on 03/23/2020 3:51:14 AM PDT by Zhang Fei (My dad had a Delta 88. That was a car. It was like driving your living room.)
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To: Bobalu

Gilead may by visiting a lot of congressmen to try and get a hold on the malaria drug.

Also will be visiting a log of doctors with “gifts”

But the cat’s out of the bag and I think there is really some great hope with that malaria drug.

YES I forgot how to spell it! Get off my back!! :)


4 posted on 03/23/2020 3:53:30 AM PDT by dp0622 (Radicals, racists my curseoint fingers at me I'm a small town white boy Just tryin to make ends meet)
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To: Zhang Fei

Since quinine used to be administered orally with gin as a sweetener (Gin and Tonic) are we going to see panic buying of Beef-Eaters and Saphire Gin?


5 posted on 03/23/2020 4:05:03 AM PDT by Fai Mao
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To: Zhang Fei
A French team on Tuesday said initial results from a 24-patient trial of hydroxychloroquine showed that 25% of patients given the drug still carried the coronavirus after six days, compared with 90% of patients given a placebo.

What Reuter-Rooters conveniently didn't mention was that in the French trial, if they added azithomycin to the hydroxychloroquine, 0% of the patients still carried the Wuhan Flu virus after 6 days.

6 posted on 03/23/2020 4:17:12 AM PDT by Fresh Wind (Never let a crisis go to waste...you can do things you thought you could not do before.)
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To: Fresh Wind

7 posted on 03/23/2020 4:19:30 AM PDT by Fresh Wind (Never let a crisis go to waste...you can do things you thought you could not do before.)
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To: Fresh Wind

[What Reuter-Rooters conveniently didn’t mention was that in the French trial, if they added azithomycin to the hydroxychloroquine, 0% of the patients still carried the Wuhan Flu virus after 6 days. ]


Interesting to know. Thanks.


8 posted on 03/23/2020 4:20:56 AM PDT by Zhang Fei (My dad had a Delta 88. That was a car. It was like driving your living room.)
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To: Fresh Wind

I noticed the same thing. A very telling omission IMO.

The media is sandbagging hydroxychloroquine because OrangeManBad spoke well of it.


9 posted on 03/23/2020 4:23:59 AM PDT by Yardstick
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To: Zhang Fei

Sorry, the correct spelling is azithromycin, an antibiotic.


10 posted on 03/23/2020 4:24:15 AM PDT by Fresh Wind (Never let a crisis go to waste...you can do things you thought you could not do before.)
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To: Yardstick

That, and the fact that the drugs are cheap, and won’t make Big Pharma a boatload of money.


11 posted on 03/23/2020 4:25:37 AM PDT by Fresh Wind (Never let a crisis go to waste...you can do things you thought you could not do before.)
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To: Fai Mao

Well, I loaded up my cart on Friday with exactly that combination.


12 posted on 03/23/2020 4:25:46 AM PDT by Mouton (The media is the enemy of the people.)
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To: Zhang Fei

They’re trying it as well in New York on Tuesday which has about 15 times more infected than any other state. How’s that open border/sanctuary city policy working out for ya Andrew Cuomo? And guess where I live? Every ones walking around here wearing masks, gloves and booties just to go shopping.

https://ncov2019.live/


13 posted on 03/23/2020 4:33:14 AM PDT by GrandJediMasterYoda (As long as Hillary Clinton remains free equal justice under the law will never exist in the USA)
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To: Fresh Wind

[Sorry, the correct spelling is azithromycin, an antibiotic.]


I’ve had the Pfizer version once for bronchitis. Good stuff.


14 posted on 03/23/2020 4:38:37 AM PDT by Zhang Fei (My dad had a Delta 88. That was a car. It was like driving your living room.)
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To: Zhang Fei

According to our pharmacist, Losartan is now on global back order. Wife has been on it for while. Obviously this is at least mildly problematic.


15 posted on 03/23/2020 4:57:46 AM PDT by FreedomPoster (Islam delenda est)
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To: Fresh Wind

I wish there were some numbers beyond that limited initial study/field trial.


16 posted on 03/23/2020 4:59:55 AM PDT by FreedomPoster (Islam delenda est)
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To: FreedomPoster

[According to our pharmacist, Losartan is now on global back order. Wife has been on it for while. Obviously this is at least mildly problematic.]


Will atenolol do, in a pinch?


17 posted on 03/23/2020 5:02:00 AM PDT by Zhang Fei (My dad had a Delta 88. That was a car. It was like driving your living room.)
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To: Zhang Fei

Dr Oz will be interviewing the Dr this afternoon Monday at 2 pm est.


18 posted on 03/23/2020 5:02:09 AM PDT by mware (RETIRED)
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To: Zhang Fei

She’s going to try to get a message into our PCP today. Obviously an alternative is a key question.


19 posted on 03/23/2020 5:03:25 AM PDT by FreedomPoster (Islam delenda est)
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To: Fresh Wind

That’s because reuter-rooters is the enemy.


20 posted on 03/23/2020 5:06:13 AM PDT by Black Agnes
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