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As colorectal cancer gets more aggressive, treatment with grape seed extract is even more effective
Science Daily ^ | January 17, 2013 | University of Colorado Denver

Posted on 11/26/2019 5:31:26 PM PST by ConservativeMind

When the going gets tough, grape seed extract gets going: A University of Colorado Cancer Center study recently published in the journal Cancer Letters shows that the more advanced are colorectal cancer cells, the more GSE inhibits their growth and survival. On the other end of the disease spectrum, GSE leaves healthy cells alone entirely.

"We've known for quite a while that the bioactive compounds in grape seed extract selectively target many types of cancer cells. This study shows that many of the same mutations that allow colorectal cancer cells to metastasize and survive traditional therapies make them especially sensitive to treatment with GSE," says Molly Derry, doctoral candidate in the lab of Rajesh Agarwal, PhD, investigator at the CU Cancer Center and professor at the Skaggs School of Pharmacy and Pharmaceutical Sciences.

"Finding a way to selectively target advanced colorectal cancer cells could have major clinical importance," Derry says.

The group performed their experiments on colorectal cancer cell lines representing various stages of the disease. Whereas it generally takes much more chemotherapy to kill a stage IV cancer cell than a stage II cancer cell, Derry saw that the reverse was true with grape seed extract.

"It required less than half the concentration of GSE to suppress cell growth and kill 50 percent of stage IV cells than it did to achieve similar results in the stage II cells," Derry says.

The group also discovered a likely mechanism of GSE's preferential targeting of advanced colorectal cancer cells: when cancer cells were treated with antioxidants the GSE induced cell death was reversed and so Derry and colleagues consider it likely that GSE targets colorectal cancer through inducing oxidative stress that leads to the programmed cell death known as apoptosis.

(Excerpt) Read more at sciencedaily.com ...


TOPICS: Health/Medicine
KEYWORDS: coloncancer; grapeseed; grapeseedextract
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In light of several FReepers dealing with Stage IV cancer.
1 posted on 11/26/2019 5:31:26 PM PST by ConservativeMind
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To: ConservativeMind

Should anyone try grape seed extract against cancer, it appears best to reduce all other forms of antioxidants, because cancer cells suck those in to disarm grape seed extract.


2 posted on 11/26/2019 5:33:48 PM PST by ConservativeMind (Trump: Befuddling Democrats, Republicans, and the Media for the benefit of the US and all mankind.)
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To: ConservativeMind

Fascinating!


3 posted on 11/26/2019 5:37:30 PM PST by LYDIAONTARIO
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To: ConservativeMind
Does eating grapes with seeds work? So many are squeamish about anything with seeds. We have become a pansy society. Seedless watermelon, seedless grapes, seedless oranges, and on and on. Seeds don't hurt anyone, if anything they serve as a sort of rooter as they travel through the intestinal tract, scouring the lining of “stuck” material as they travel through, aiding peristalsis and are similar to fiber.
4 posted on 11/26/2019 5:49:02 PM PST by Fungi
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To: ConservativeMind

Where would one buy grape seed?


5 posted on 11/26/2019 5:57:24 PM PST by Inyo-Mono
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To: ConservativeMind
I had stage 4 colorectal cancer in 1996. I survived the radiation and poison. I wonder what side effects GSE have? Can’t be any worse than the diarrhea that lasted for 10 weeks.
6 posted on 11/26/2019 6:02:11 PM PST by jimtorr
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BFL


7 posted on 11/26/2019 6:02:32 PM PST by Faith65 (Isaiah 40:31)
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To: Inyo-Mono

Online at Amazon or at a health food market like Sprouts or Whole Foods.


8 posted on 11/26/2019 6:04:45 PM PST by beaversmom (Trump for Cali gov 2026. Make CA great again.)
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To: Inyo-Mono
Amazon or your local Vitamin Shoppe or GNC.

I’ve taken over 4,000 mg a day, spread throughout each day, for each of five days, on two separate occasions.

I once took over 6,000 at once and had “issues.”

9 posted on 11/26/2019 6:12:44 PM PST by ConservativeMind (Trump: Befuddling Democrats, Republicans, and the Media for the benefit of the US and all mankind.)
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To: Fungi

I doubt your body would absorb as much with ground whole seeds.


10 posted on 11/26/2019 6:13:30 PM PST by ConservativeMind (Trump: Befuddling Democrats, Republicans, and the Media for the benefit of the US and all mankind.)
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To: jimtorr

I had it in 2011. Two major surgeries, lost about 2 ft of my colon, had a colostomy bag for about a year, and back to my not normal self. I refused chemo and radiation.

Still here.. damn...


11 posted on 11/26/2019 6:15:07 PM PST by tired&retired (Blessings)
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To: jimtorr

Very good to hear you made it. God bless you.


12 posted on 11/26/2019 6:15:41 PM PST by laplata (The Left/Progressives have diseased minds.)
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To: tired&retired

Great for you.


13 posted on 11/26/2019 6:16:18 PM PST by laplata (The Left/Progressives have diseased minds.)
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To: jimtorr

Congrats on 23 years!

Happy Thanksgiving to you and yours.


14 posted on 11/26/2019 6:16:27 PM PST by Jane Long (Praise God, from whom ALL blessings flow.)
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To: ConservativeMind

Thank you for the info.


15 posted on 11/26/2019 6:21:34 PM PST by Inyo-Mono
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To: ConservativeMind

In the mid-20th century, it was called Laetrile and was denounced by the big money funded cancer industry. The cancer industry labeled ‘mistakes’ in the Slone-Kettering studies as “inconsequential” and rely on those studies to attack the treatment.


16 posted on 11/26/2019 6:48:50 PM PST by PAR35
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To: Inyo-Mono

iHerb.com and StopAgingNow.com are both excellent with 1-2 day turnaround, at least here in the Midwest.


17 posted on 11/26/2019 7:16:02 PM PST by BrandtMichaels
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To: ConservativeMind
The effect of grape seed extract on estrogen levels of postmenopausal women: A pilot study.

https://mayoclinic.pure.elsevier.com/en/publications/the-effect-of-grape-seed-extract-on-estrogen-levels-of-postmenopa

18 posted on 11/26/2019 7:17:35 PM PST by Right Wing Assault (Kill-googl,TWTR,FCBK,NYT,WaPo,Hwd,CNN,NFL,BLM,CAIR,Antfa,SPLC,ESPN,NPR,NBA,ARP)
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To: ConservativeMind

Grape seeds (and probably the extract) are supposed to be good for retina issues, too. My friend’s young daughter (7 y.o.) was diagnosed with a totally scary and rare retina disease which doesn’t improve. Treatment was a mystery. Her parents read about grape seeds and she was eating a LOT of seeded white grapes. Her last checkup was last week (she’s 9 y.o. now), and there was no sign of the disease, and her vision was 20/20.

Maybe it was a coincidence, and maybe it would’ve improved anyhow, but it’s an interesting story.


19 posted on 11/26/2019 7:22:57 PM PST by MayflowerMadam ("I've read the back of The Book, and we win.")
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To: PAR35

Not to be argumentative, but I thought laetrile was apricot pits.


20 posted on 11/26/2019 7:25:56 PM PST by Flaming Conservative ((Pray without ceasing))
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