Posted on 10/28/2019 3:54:31 PM PDT by SunkenCiv
People who take all of their blood-pressure medication in one go at bedtime are better able to control their condition and have “a significantly lower risk of death or illness” caused by heart or blood vessel problems compared to those who take their anti-hypertensive medication in the morning, according to research published this month in the peer-reviewed European Heart Journal.
The trial instructed 19,084 patients to take their pills on waking or at bedtime, and followed them for more than six years — during which time the patients’ ambulatory blood pressure was checked over 48 hours at least once a year. The results were adjusted for age, gender, Type 2 diabetes, kidney disease, smoking and cholesterol levels.
The researchers found that patients who took their medication at bedtime reduced by 45% their risk of dying from or suffering heart attacks, myocardial infarction, stroke, heart failure or requiring a procedure to unblock narrowed arteries, compared to those who took their medication after waking up in the morning.
The risk of death from heart or blood vessel problems was reduced by 66%, the risk of myocardial infarction was reduced by 44%, coronary revascularization (unblocking narrowed arteries) by 40%, heart failure by 42%, and stroke by 49%. However, the researchers noted there are no studies showing that treating hypertension in the morning reduces the risk of cardiovascular disease.
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I couldn’t take the lisinopril.
It lowered my pulse rate, and so low that one time the nurses were having a hard time finding my pulse - but, strangely, I felt fine. Went to lunch and returned to see the doctor and she swicthed me to losartan - in addition to the HCTZ.
It’s interesting that the results appear to have been the same irrespective of the chemical being used. Sounds like the BP drug doesn’t work as well / is counteracted by daily activities.
Sounds like the same thing I take.
I take losartan and it reduces my bp better than lisinopril, but the positive effects don’t last long enough. My bp tends to be lower during daylight than at night. It rises dangerously at night. I used to take lisonipril at night and one of my docs didn’t like it altho another doc prescribed it that way. I’m going to try the losartan at night and see if it works better that way. I can take all the pee pills during the day.
LOL! Definitely a good exercise regimen! Wind sprints!
I like that my prostate wakes me up in the night so i can check Free Republic for the latest
I concur. That is a shocking number.
Did you start with a gel or a patch on the “T”? Also, I’m curious how you got the testosterone therapy approved to begin with if the blood test did not show a low value (under 300, roughly).
My wife and I had a little white coat syndrome re higher BP when taken at the beginning of an appointment with a doctor and lower at the end of the appointment.
When I take my bp med the night before, the bps are in the normal range pre and post visit.
LOL I hadn't thought of that on my late night potty trips!
“BP drug doesn’t work as well / is counteracted by daily activities.”
Could be a lot of variables impacting blood levels and tissue absorption.
We really don’t how and why our bodies and blood chemistry vary over a 24 hour period.
Some studies are being done with drugs that have something added like a nuclear tag to measure levels over the dosing periods.
” I’m going to try the losartan at night and see if it works better that way. I can take all the pee pills during the day.”
The textbooks say that loasartan at 100mg is still 85% effective 24 hours later, but not at lower doses. But then again, depending on how bad the high BP is, 100mg may be more than needed and can lower the BP too much when it is at top strength, in the earliest hours after taking it.
My dose is 50mg but that dose is to be taken twice a day.
I just found the noon and bed time arrangement works well and kept to it.
The one thing I have learned about most medicines is that it is best to keep to a fairly strict timing regimen. The exact time is usually less important that keeping close to the same time each day, whatever that is. s better than taking the same medicine at hop scotch random times a day, as if “once a day” means only that as long as you at least take it “once a day” that is good enough. I don’t think so.
Arriving at what is a good standard dose for someone, using an initial period of trying a BP med, CANNOT be found in that intitial period if the medicine is taken at all kinds of different times of the day. The amount of the medicine that is active in the blood stream is too irregular if taking of the medicine is too irregular.
Taking our pills with consittent regularity as to the time of day is important to having them work as intended.
I have a sister in law who committed that patient “crime”, with disastrous results. She had more than one hospitalization because she was totally irregular with her medications. My brother and I and her doctors had to lecture her many times about how they could not get her meds right if she kept taking them willy nilly, whenever it suited her. A number of her blood readings (not just BP) were going from big escalations to major lows, with her rocking between sleepy all the time to not getting any sleep, and back and forth. There was nothing really wrong with her meds. She was the problem.
I worked with her in laying out her meds for the day in the morning, taking all the meds needed to be taken between then and the next morning, with the right doses taken out of the prescritpion bottles and put in a container, or containers for the day. Ther is no missing of pills if she only remembers to check the container(s), and there she can see how many doses are left and if she needs to take one. I have her setting that up next to her where she works at home, and taking it with her in her purse when she goes out, and next to her bed at night. There is no going to the prescription bottles, everything for the day, and only all that is needed fort the day is already out and handy.
Aspirin as a therapeutic for BP was discounted for most studies, except for one that looked at it taken at bed time that seemed to have a positive effect.
Back when I was young and thin, and really for a long time thereafter, my rest BP was in double digits (both systolic and, uh, apostolic or whatever). The first time I remember getting my BP taken was for the physical for Boy Scout camp, and my nerves about that may have actually caused a bit of a BP falloff — it came out 80/60. My doctor at the time was still the doctor present at my birth, and it surprised him.
THat’s when most people take it, usually the 81 mg. Ultimately, the mortality rate is still 100%, but a single aspirin a day doesn’t seem to do harm, either.
Lordy. I take Tiazac, Lisinopril, and Bisoprolol in the morning, plus a Lasix. Then the Farxiga I take for my Type II plays wingman for the Lasix, and I pee like a baby race horse for about four hours.
I agree.
I recently had a pace maker implanted and I have to take Metoprol once a day. The stuff can leave me feeling like I’m pushing a freight train uphill. I think I’ll take before I go to bed. You’re on to something there.
Run a half hour 3 times a week.
That is how the body lowers blood pressure naturally.
The SECRET is OUT !!!
Thanks all. Good off-topic topic to ping to all lists.
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